当前位置： SCI文献检索 > VIRUS RESEARCH期刊下所有文献 > The peptide encoded by a novel putative lncRNA HBVPTPAP inducing the apoptosis of hepatocellular carcinoma cells by modulating JAK/STAT signaling pathways.

The peptide encoded by a novel putative lncRNA HBVPTPAP inducing the apoptosis of hepatocellular carcinoma cells by modulating JAK/STAT signaling pathways.

Abstract：

:When the hepatitis B virus (HBV) enters target cells, there are complex trans-regulatory mechanisms involved in the interactions between the virus and the target cells. In the present study, a new gene screened from the hepatoblastoma cell line HepG2 using suppression subtractive hybridization, referred to as lncRNA HBVPTPAP, was used to study the trans-regulation of HBV DNA polymerase. According to the structural characteristics of the full-length sequences, it was classified as long non-coding RNA. However, a unique and complete open reading frame (ORF) was still present. Therefore, to further identify the lncRNA HBVPTPAP gene's encoding potential, this study used several online tools to analyze and verify its encoding polypeptide authenticity. On that basis, the effects of the lncRNA HBVPTPAP gene on the biological behaviors of HepG2 cells and its molecular regulatory mechanism were investigated. It was found that the lncRNA HBVPTPAP subcellular was mainly located in the cytoplasm, and possibly activated the downstream JAK/STAT signaling pathway through the interaction between the encoding polypeptide and PILRA intracellular domain. Then, the mitochondrial apoptosis pathway may have been initiated to induce apoptosis. These results provided a basis for further study of the biological functions of the lncRNA HBVPTPAP gene.

journal_name

Virus Res

journal_title

Virus research

authors

Lun YZ,Pan ZP,Liu SA,Sun J,Han M,Liu B,Dong W,Pan LH,Cheng J

doi

10.1016/j.virusres.2020.198104

subject

Has Abstract

pub_date

2020-10-02 00:00:00

pages

198104

eissn

0168-1702

issn

1872-7492

pii

S0168-1702(20)30862-5

journal_volume

287

pub_type

杂志文章

相关文献

VIRUS RESEARCH文献大全
  • Gene expression regulated by gene VI of caulimovirus: transactivation of downstream genes of transcripts by gene VI of peanut chlorotic streak virus in transgenic tobacco.

    abstract：:Here we document that the gene VI product of peanut chlorotic streak virus (PClSV), a newly characterized member of the group, transactivates the translation of dicistronic transcripts. Dicistronic expression units have been analyzed both in protoplast transient expression experiments and in transgenic tobacco plants....

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/s0168-1702(98)00088-4

    authors： Maiti IB,Richins RD,Shepherd RJ

    更新日期：1998-10-01 00:00:00

  • Persistence of parvovirus H-1 DNA in human B- and T-lymphoma cells.

    abstract：:Persisting DNA of parvovirus H-1 could be demonstrated in cells of two human lymphoma cell lines, the Burkitt lymphoma cell line BL2 and the T-cell leukemia cell line Jurkat which survived infection with parvovirus H-1. Persistence of H-1 DNA rendered the cells resistant to a second H-1 infection. This resistance to H...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/0168-1702(90)90024-6

    authors： Faisst S,Bartnitzke S,Schlehofer JR,zur Hausen H

    更新日期：1990-06-01 00:00:00

  • Phylogenetic studies of influenza B viruses isolated in southern Africa: 1998-2001.

    abstract：:Influenza B viruses isolated in southern Africa during the period from 1998 to 2001 were analysed by sequence analysis of the viral haemagglutinin HA1 subunit and the phylogenetic relationships were determined. Influenza B activity varied considerably in South Africa during the 4-year study period with no activity det...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2004.02.014

    authors： Besselaar TG,Botha L,McAnerney JM,Schoub BD

    更新日期：2004-07-01 00:00:00

  • Aberrant expression of liver microRNA in chickens infected with subgroup J avian leukosis virus.

    abstract：:Subgroup J avian leukosis virus (ALV-J) is an oncogenic retrovirus primarily causing myeloid leukosis (ML) in broilers. Although ALV is well under control in a few countries including the USA, poultry industry in many parts of the world continues suffering from serious economic loss due to sporadic or widespread ALV i...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2012.07.003

    authors： Li H,Ji J,Xie Q,Shang H,Zhang H,Xin X,Chen F,Sun B,Xue C,Ma J,Bi Y

    更新日期：2012-10-01 00:00:00

  • Nucleotide sequence variation of the VP7 gene of two G3-type rotaviruses isolated from dogs.

    abstract：:The sequence of the VP7 gene of two rotaviruses isolated from dogs in southern Italy was determined and the inferred amino acid sequence was compared with that of other rotavirus strains. There was very high nucleotide and amino acid identity between canine strain RV198/95 and other canine strains, and to the human st...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/s0168-1702(00)00230-6

    authors： Martella V,Pratelli A,Greco G,Gentile M,Fiorente P,Tempesta M,Buonavoglia C

    更新日期：2001-04-01 00:00:00

  • Heterogeneity of the L2 gene of field isolates of bluetongue virus serotype 17 from the San Joaquin Valley of California.

    abstract：:Genome segment 2 (L2) from six field isolates of bluetongue virus (BTV) serotype 17 was sequenced by cycling sequencing after the amplification of the viral cDNA by the polymerase chain reaction. The viruses were isolated from sheep, cattle and a goat in the San Joaquin Valley of California during the years 1981 and 1...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/0168-1702(94)90072-8

    authors： de Mattos CA,de Mattos CC,Osburn BI,MacLachlan NJ

    更新日期：1994-01-01 00:00:00

  • Inhibition of white spot syndrome virus replication in Penaeus monodon by combined silencing of viral rr2 and shrimp PmRab7.

    abstract：:Although a significant progress has been achieved on dsRNA mediated anti-virus strategy development, there is still no effective means to control the virulent white spot syndrome virus (WSSV). Six double-stranded RNAs specific to different essential genes of WSSV (ie1, ie3, pol (DNA polymerase), rr2 (ribonucleotide re...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2009.06.018

    authors： Attasart P,Kaewkhaw R,Chimwai C,Kongphom U,Namramoon O,Panyim S

    更新日期：2009-10-01 00:00:00

  • Chimeric VLPs with GII.3 P2 domain in a backbone of GII.4 VP1 confers novel HBGA binding ability.

    abstract：:Noroviruses (NoVs) are a leading cause of non-bacterial acute gastroenteritis worldwide. The prevalence of Genogroup II, genotype 3 (GII.3) NoVs is secondary to the epidemic GII.4 strains which show broad spectrum binding activities against multiple types of histo-blood group antigens (HBGAs). In our previous study it...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2016.08.006

    authors： Huo Y,Wang W,Ling T,Wan X,Ding L,Shen S,Huo J,Zhang S,Wang M,Wang Y,Liu Y

    更新日期：2016-09-15 00:00:00

  • Visualization of intracellular pathways of engineered baculovirus in mammalian cells.

    abstract：:Baculoviruses are a promising gene delivery vector. They have the ability to express large transgenes in mammalian cells without displaying pathogenicity in humans; however, little is known about their transduction mechanisms in target cells. In this study, we use colocalization and live-cell imaging studies to elucid...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2014.01.006

    authors： Liu Y,Joo KI,Lei Y,Wang P

    更新日期：2014-03-06 00:00:00

  • Tomato spotted wilt virus glycoprotein G(C) is cleaved at acidic pH.

    abstract：:Tomato spotted wilt virus (TSWV) is a plant-infecting member of the family Bunyaviridae. TSWV encodes two envelope glycoproteins, G(N) and G(C), which are required for virus infection of the arthropod vector. Other members of the Bunyaviridae enter host cells by pH-dependent endocytosis. During this process, the glyco...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2005.01.007

    authors： Whitfield AE,Ullman DE,German TL

    更新日期：2005-06-01 00:00:00

  • The evolution of collective infectious units in viruses.

    abstract：:Viruses frequently spread among cells or hosts in groups, with multiple viral genomes inside the same infectious unit. These collective infectious units can consist of multiple viral genomes inside the same virion, or multiple virions inside a larger structure such as a vesicle. Collective infectious units deliver mul...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2019.03.013

    authors： Leeks A,Sanjuán R,West SA

    更新日期：2019-05-01 00:00:00

  • Mutation of conserved N-glycosylation sites around the CD4-binding site of human immunodeficiency virus type 1 GP120 affects viral infectivity.

    abstract：:Infection by the human immunodeficiency virus type 1 (HIV-1) is initiated through interaction of its exterior envelope glycoprotein gp120 with the CD4 receptor on target cells. To address the possible role of N-glycosylation of HIV-1 gp120 in binding CD4, we mutated different conserved N-glycosylation site Asn-residue...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/0168-1702(90)90085-p

    authors： Dirckx L,Lindemann D,Ette R,Manzoni C,Moritz D,Mous J

    更新日期：1990-12-01 00:00:00

  • Characterization of a highly pathogenic avian influenza H5N1 clade 2.3.4 virus isolated from a tree sparrow.

    abstract：:The spread of H5N1 virus into a wide range of avian and mammalian species may facilitate the adaptation of the virus to human populations. In the present study, a survey of avian influenza virus in tree sparrows was performed and a HPAI H5N1 virus (A/tree sparrow/Jiangsu/1/08) was isolated. The H5N1 virus was found to...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2009.09.014

    authors： Liu Q,Ma J,Kou Z,Pu J,Lei F,Li T,Liu J

    更新日期：2010-01-01 00:00:00

  • LncRNA, miRNA and lncRNA-miRNA interaction in viral infection.

    abstract：:Noncoding RNAs (ncRNAs) are key components of the transcriptome and play an important role in both normal biological activity and pathological processes such as viral infection and tumorigenesis. LncRNAs and miRNAs are the most important elements of ncRNAs and function as vital regulatory elements. Their complex regul...

    journal_title：Virus research

    pub_type： 杂志文章,评审

    doi：10.1016/j.virusres.2018.08.018

    authors： Chen L,Zhou Y,Li H

    更新日期：2018-09-15 00:00:00

  • Effect of lysosomotropic compounds on early events in foot-and-mouth disease virus replication.

    abstract：:The effect of three lysosomotropic compounds, chloroquine, monensin and NH4Cl, on the replication of foot-and-mouth disease virus (FMDV) type A12 was studied. Viral replication was almost totally inhibited by 0.5 mM chloroquine, 50 microM monensin, or 25 mM NH4Cl. Monensin and NH4Cl affected replication when added eit...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/0168-1702(87)90032-3

    authors： Baxt B

    更新日期：1987-05-01 00:00:00

  • Methylation of the polyomavirus major capsid protein VP1.

    abstract：:Polyomavirus VP1 has been shown to be modified by phosphorylation, sulfation, acetylation and hydroxylation. The major capsid protein VP1 is now shown to be modified by methylation. Addition of cycloheximide to infected cultures followed by addition of [3H-methyl]-L-methionine and subsequent immunoprecipitation, SDS-P...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/0168-1702(95)01266-4

    authors： Burton KS,Consigli RA

    更新日期：1996-02-01 00:00:00

  • Self-assembly of double-stranded RNA bacteriophages.

    abstract：:Double-stranded RNA viruses infecting bacterial hosts belong to the Cystoviridae family. Bacteriophage phi6 is one of the best characterized dsRNA viruses and shares structural as well as functional similarities with other well-studied eukaryotic dsRNA viruses (e.g. L-A, rotavirus, bluetongue virus, and reovirus). The...

    journal_title：Virus research

    pub_type： 杂志文章,评审

    doi：10.1016/j.virusres.2003.12.009

    authors： Poranen MM,Tuma R

    更新日期：2004-04-01 00:00:00

  • CRISPR-Cas9 system-driven site-specific selection pressure on Herpes simplex virus genomes.

    abstract：:The CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9) system has been widely used for viral genome editing, transcription regulation and chromosomal localization in eukaryotic cells. In this study, a guide RNA (gRNA) that specifically recognizes HSV-1 viral genomes...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2017.03.010

    authors： Li Z,Bi Y,Xiao H,Sun L,Ren Y,Li Y,Chen C,Cun W

    更新日期：2018-01-15 00:00:00

  • RNA viruses and their silencing suppressors boost Abutilon mosaic virus, but not the Old World Tomato yellow leaf curl Sardinia virus.

    abstract：:Mixed viral infections can induce different changes in symptom development, genome accumulation and tissue tropism. These issues were investigated for two phloem-limited begomoviruses, Abutilon mosaic virus (AbMV) and Tomato yellow leaf curl Sardinia virus (TYLCSV) in Nicotiana benthamiana plants doubly infected by ei...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2011.07.021

    authors： Sardo L,Wege C,Kober S,Kocher C,Accotto GP,Noris E

    更新日期：2011-11-01 00:00:00

  • Reversion to wildtype of a mutated and nonfunctional coxsackievirus B3CRE(2C).

    abstract：:The cis-acting replication element (CRE) in the 2C protein coding region [CRE(2C)] of enteroviruses (EV) facilitates the addition of two uridine residues (uridylylation) onto the virus-encoded protein VPg in order for it to serve as the RNA replication primer. We demonstrated that coxsackievirus B3 (CVB3) is replicati...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2016.04.016

    authors： Smithee S,Tracy S,Chapman NM

    更新日期：2016-07-15 00:00:00

  • Trans-activation of viral tk promoters by proteins encoded by varicella zoster virus open reading frames 61 and 62.

    abstract：:Plasmids containing the varicella zoster virus (VZV) open reading frames (ORFs) 61 and 62 were used in a transient co-transfection assay to test for trans-activation of the VZV and herpes simplex virus type 1 (HSV-1) thymidine kinase (tk) promoters. The trans-activating potential of the polypeptides encoded by these V...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/0168-1702(90)90013-2

    authors： Cabirac GF,Mahalingam R,Wellish M,Gilden DH

    更新日期：1990-01-01 00:00:00

  • In vitro and in vivo activity of AS101 against West Nile virus (WNV).

    abstract：:There are currently no effective drugs to treat serious complications caused by WNV infection. The inhibition of WNV by the pluripotent immunomodulator AS101 [ammonium trichloro(dioxyethylene-0-0')tellurate] was evaluated in vitro and in vivo, and its mechanism was explored. Adding AS101 to Vero cells 1h or 5 min befo...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2012.03.004

    authors： Indenbaum V,Bin H,Makarovsky D,Weil M,Shulman LM,Albeck M,Sredni B,Mendelson E

    更新日期：2012-06-01 00:00:00

  • Beta-actin interacts with the E2 protein and is involved in the early replication of classical swine fever virus.

    abstract：:The E2 glycoprotein of classical swine fever virus (CSFV) is involved in viral infection and induction of neutralizing antibodies. Little is known about how E2 interacts with host cells. To understand the cellular factors involved in viral replication cycle, E2 was used as bait in yeast two-hybrid screens, resulting i...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2013.10.016

    authors： He F,Ling L,Liao Y,Li S,Han W,Zhao B,Sun Y,Qiu HJ

    更新日期：2014-01-22 00:00:00

  • The Tat protein of the human immunodeficiency virus type 1 (HIV-1) interacts with the EGF-like repeats of the Notch proteins and the EGF precursor.

    abstract：:Employing the yeast two-hybrid system, the Tat protein of the human immunodeficiency virus (HIV) was shown to interact with a region spanning the EGF-like repeats 1-6 of the mouse Notch1, the human Notch2 and the Drosophila Notch. This observation was confirmed in mammalian cells by demonstrating an interaction betwee...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2003.08.016

    authors： Shoham N,Cohen L,Yaniv A,Gazit A

    更新日期：2003-12-01 00:00:00

  • Mutations in the coat protein-binding cis-acting RNA motifs debilitate RNA recombination of Brome mosaic virus.

    abstract：:We have previously described the efficient homologous recombination system between 5' subgenomic RNA3a (sgRNA3a) and genomic RNA3 of Brome mosaic virus (BMV) in barley protoplasts (Sztuba-Solińska et al., 2011a). Here, we demonstrated that sequence alterations in the coat protein (CP)-binding cis-acting RNA motifs, th...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2012.10.001

    authors： Sztuba-Solińska J,Fanning SW,Horn JR,Bujarski JJ

    更新日期：2012-12-01 00:00:00

  • Rapamycin enhances lytic replication of Epstein-Barr virus in gastric carcinoma cells by increasing the transcriptional activities of immediate-early lytic promoters.

    abstract：:Epstein-Barr virus (EBV), a human herpesvirus, is linked to both epithelial and lymphoid malignancies. Induction of EBV reactivation is a potential therapeutic strategy for EBV-associated tumors. In this study, we assessed the effects of rapamycin on EBV reactivation in gastric carcinoma cells. We found that rapamycin...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2017.11.021

    authors： Wang M,Wu W,Zhang Y,Yao G,Gu B

    更新日期：2018-01-15 00:00:00

  • Antigenicity of hantavirus nucleocapsid proteins expressed in E. coli.

    abstract：:DNA clones representing the small genomic segment of Nephropathia epidemica virus strain Hällnäs B1 (NEV) and Hantaan virus strain 76-118 (HTV) encoding their nucleocapsid proteins were inserted into the E. coli vector pIN-III-ompA for secretion of proteins into the periplasmic space. The complete HTV and NEV nucleoca...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/0168-1702(91)90090-i

    authors： Gött P,Zöller L,Yang S,Stohwasser R,Bautz EK,Darai G

    更新日期：1991-03-01 00:00:00

  • The role of secreted glycoprotein G of equine herpesvirus type 1 and type 4 (EHV-1 and EHV-4) in immune modulation and virulence.

    abstract：:Equine herpesvirus type 1 and 4 (EHV-1 and EHV-4) are important pathogens of horses worldwide. Infection with EHV-4 usually remains restricted to the upper respiratory tract, whereas infection with EHV-1 can generalize after leukocyte-associated viremia. Here we examined whether differences in the immunomodulatory gly...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2012.07.029

    authors： Thormann N,Van de Walle GR,Azab W,Osterrieder N

    更新日期：2012-10-01 00:00:00

  • Genetic and phylogenetic analysis of the core proteins VP1, VP3, VP4, VP6 and VP7 of epizootic haemorrhagic disease virus (EHDV).

    abstract：:The core proteins of epizootic haemorrhagic disease virus (EHDV) have important roles to perform in maintaining the structure and function of the virus. A complete genetic and phylogenetic analysis was therefore performed on these proteins (and the genes that code for them) to allow comparison of the selective pressur...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2009.07.011

    authors： Anthony SJ,Maan N,Maan S,Sutton G,Attoui H,Mertens PP

    更新日期：2009-11-01 00:00:00

  • Changes in antiviral susceptibility to entry inhibitors and endocytic uptake of dengue-2 virus serially passaged in Vero or C6/36 cells.

    abstract：:The aim of the present study was to analyze the influence of virus origin, mammalian or mosquito cell-derived, on antiviral susceptibility of DENV-2 to entry inhibitors and the association of this effect with any alteration in the mode of entry into the cell. To this end, ten serial passages of DENV-2 were performed i...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2014.02.011

    authors： Acosta EG,Piccini LE,Talarico LB,Castilla V,Damonte EB

    更新日期：2014-05-12 00:00:00