当前位置： SCI文献检索 > VIRUS RESEARCH期刊下所有文献 > The Tat protein of the human immunodeficiency virus type 1 (HIV-1) interacts with the EGF-like repeats of the Notch proteins and the EGF precursor.

The Tat protein of the human immunodeficiency virus type 1 (HIV-1) interacts with the EGF-like repeats of the Notch proteins and the EGF precursor.

Abstract：

:Employing the yeast two-hybrid system, the Tat protein of the human immunodeficiency virus (HIV) was shown to interact with a region spanning the EGF-like repeats 1-6 of the mouse Notch1, the human Notch2 and the Drosophila Notch. This observation was confirmed in mammalian cells by demonstrating an interaction between the HIV Tat and the EGF-like repeats 1-6 of the various Notch proteins. The HIV Tat protein interacted also with the full-length mouse Notch1 receptor when co-expressed in mammalian cells. Moreover, the HIV Tat protein interacted also with the EGF-like repeats 1-4-spanning domain of the human EGF precursor. The ability of the HIV Tat protein to interact with the Notch proteins and possibly with other EGF-like repeats-bearing proteins, suggests that such interactions might modulate their physiological functions, thus affecting various AIDS-associated pathologies.

journal_name

Virus Res

journal_title

Virus research

authors

Shoham N,Cohen L,Yaniv A,Gazit A

doi

10.1016/j.virusres.2003.08.016

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

57-61

issue

1

eissn

0168-1702

issn

1872-7492

pii

S0168170203002545

journal_volume

98

pub_type

杂志文章

相关文献

VIRUS RESEARCH文献大全
  • Reversion to wildtype of a mutated and nonfunctional coxsackievirus B3CRE(2C).

    abstract：:The cis-acting replication element (CRE) in the 2C protein coding region [CRE(2C)] of enteroviruses (EV) facilitates the addition of two uridine residues (uridylylation) onto the virus-encoded protein VPg in order for it to serve as the RNA replication primer. We demonstrated that coxsackievirus B3 (CVB3) is replicati...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2016.04.016

    authors： Smithee S,Tracy S,Chapman NM

    更新日期：2016-07-15 00:00:00

  • Synonymous codon usage pattern analysis of Hepatitis D virus.

    abstract：:Hepatitis D virus (HDV) is the smallest animal infecting RNA virus with unique features distinguishing it from other Hepatitis viruses. Codon usage variation is considered as an indicator of the forces shaping genome evolution. RSCU (relative synonymous codon usage) values, nucleotide contents, ENC (effective number o...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2013.01.007

    authors： Bishal AK,Mukherjee R,Chakraborty C

    更新日期：2013-05-01 00:00:00

  • Interaction of cellular poly(C)-binding protein 2 with nonstructural protein 1β is beneficial to Chinese highly pathogenic porcine reproductive and respiratory syndrome virus replication.

    abstract：:Non-structural protein1β (Nsp1β) of porcine reproductive and respiratory syndrome virus (PRRSV) has been recognized to be involved in suppressing the host innate immune response and mediating viral subgenomic mRNA transcription. In the present study, we have analyzed the interaction of Nsp1β of Chinese highly pathogen...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2012.08.002

    authors： Wang L,He Q,Gao Y,Guo X,Ge X,Zhou L,Yang H

    更新日期：2012-10-01 00:00:00

  • Glycoprotein C of equine herpesvirus 4 plays a role in viral binding to cell surface heparan sulfate.

    abstract：:Heparan sulfate moieties of cell surface proteoglycans serve as receptors for several herpesviruses. For herpes simplex virus 1, pseudorabies virus and equine herpesvirus 1, glycoprotein C (gC) homologues have been shown to mediate the binding to cell surface heparan sulfate. However, the role of gC in equine herpesvi...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2010.03.003

    authors： Azab W,Tsujimura K,Maeda K,Kobayashi K,Mohamed YM,Kato K,Matsumura T,Akashi H

    更新日期：2010-07-01 00:00:00

  • An improved in vitro and in vivo Sindbis virus expression system through host and virus engineering.

    abstract：:The Sindbis viral expression system enables the rapid production of high levels of recombinant protein in mammalian cells; however, this expression is typically limited to transient production due to the cytotoxicity of the virus. Limiting the lethality inherent in the Sindbis virus vector in order to enable long term...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2008.12.019

    authors： Nivitchanyong T,Tsai YC,Betenbaugh MJ,Oyler GA

    更新日期：2009-04-01 00:00:00

  • Identification, transmission and genomic characterization of a new member of the family Caulimoviridae causing a flower distortion disease of Rudbeckia hirta.

    abstract：:A disease of Rudbeckia hirta (Black-eyed Susan), characterized by severe flower deformation, was observed in Minnesota during 2010-2016. A previously undescribed virus species, named Rudbeckia flower distortion virus (RuFDV, family Caulimoviridae, genus unassigned), was determined to be the causal agent of the disease...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2017.05.012

    authors： Lockhart B,Mollov D,Olszewski N,Goldsmith N

    更新日期：2017-09-15 00:00:00

  • The peptide encoded by a novel putative lncRNA HBVPTPAP inducing the apoptosis of hepatocellular carcinoma cells by modulating JAK/STAT signaling pathways.

    abstract：:When the hepatitis B virus (HBV) enters target cells, there are complex trans-regulatory mechanisms involved in the interactions between the virus and the target cells. In the present study, a new gene screened from the hepatoblastoma cell line HepG2 using suppression subtractive hybridization, referred to as lncRNA H...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2020.198104

    authors： Lun YZ,Pan ZP,Liu SA,Sun J,Han M,Liu B,Dong W,Pan LH,Cheng J

    更新日期：2020-10-02 00:00:00

  • Major amino acid sequence variants of viral vascular endothelial growth factor are functionally equivalent during Orf virus infection of sheep skin.

    abstract：:Orf virus infection causes a contagious pustular dermatitis characterized by extensive vascular changes that have been linked to a virally encoded vascular endothelial growth factor (VEGF). The VEGF genes of different strains of orf virus can vary extensively in amino acid sequence. Functional analyses of two major va...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2007.04.018

    authors： Wise LM,Savory LJ,Dryden NH,Whelan EM,Fleming SB,Mercer AA

    更新日期：2007-09-01 00:00:00

  • Molecular epidemiology of rabies virus isolates from South Korea.

    abstract：:A molecular epidemiological study was performed on 13 Korean virus isolates, which were collected from wild and domestic animals diagnosed as rabid between 1998 and 2004. Seven samples were from domestic animals such as dogs and cattle infected by rabid raccoon dogs (Nyctereutes procyonoides koreensis), and the rest o...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2005.06.004

    authors： Hyun BH,Lee KK,Kim IJ,Lee KW,Park HJ,Lee OS,An SH,Lee JB

    更新日期：2005-12-01 00:00:00

  • Mutational analysis of the feline immunodeficiency virus matrix protein.

    abstract：:To study the process of feline immunodeficiency virus (FIV) assembly, we examined the suitability of the vaccinia vector system to reproduce FIV particle formation. To this end, we constructed a recombinant vaccinia virus carrying the FIV gag gene. Biochemical and electron microscopy analyses of cells infected with th...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/s0168-1702(01)00249-0

    authors： Manrique ML,Celma CC,González SA,Affranchino JL

    更新日期：2001-07-01 00:00:00

  • Replication of varicella zoster virus in Raji cells.

    abstract：:This report provides evidence for the replication of varicella zoster virus (VZV) in Raji cells. Infection was achieved by co-cultivation of Raji cells with VZV-infected human fibroblasts. Replication of VZV, as assessed by immunofluorescence using monoclonal antibodies against VZV-glycoproteins, ranged from 18 to 24%...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/0168-1702(86)90080-8

    authors： Cauda R,Chatterjee S,Tilden AB,Grossi CE,Whitley RJ

    更新日期：1986-06-01 00:00:00

  • In vitro synthesis of Japanese encephalitis virus (JEV) RNA: membrane and nuclear fractions of JEV-infected cells possess high levels of virus-specific RNA polymerase activity.

    abstract：:Japanese encephalitis virus (JEV)-specific RNAs (including 42S RNA) were synthesized in subcellular fractions prepared from infected C6/36 cells. This in vitro RNA synthesis essentially required Mg2+ and four ribonucleotides, and it was enhanced by K+. The amounts of RNA synthesized in vitro (in extracts from JEV-infe...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/0168-1702(89)90078-6

    authors： Takegami T,Hotta S

    更新日期：1989-08-01 00:00:00

  • Detection of members of the Secoviridae in the Tallgrass Prairie Preserve, Osage County, Oklahoma, USA.

    abstract：:Viruses are most frequently discovered because they cause disease. To expand knowledge of plant-associated viruses beyond these narrow constraints, non-cultivated plants of the Tallgrass Prairie of the United States were systematically surveyed for evidence of viruses. This report discusses putative viruses of the fam...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2012.03.016

    authors： Thapa V,Melcher U,Wiley GB,Doust A,Palmer MW,Roewe K,Roe BA,Shen G,Roossinck MJ,Wang YM,Kamath N

    更新日期：2012-07-01 00:00:00

  • Identification of a protein encoded in the herpes simplex virus type 1 latency associated transcript promoter region.

    abstract：:Herpes simplex virus type 1 (HSV-1) establishes a lifelong latency in the neurons of its host. Sporadically, the latent virus reactivates and spreads back to the original site of infection and causes recrudescent diseases. The only gene actively transcribed during neuronal latency is the latency associated transcript ...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2004.08.011

    authors： Naito J,Mukerjee R,Mott KR,Kang W,Osorio N,Fraser NW,Perng GC

    更新日期：2005-03-01 00:00:00

  • Inhibition of Theiler's virus-induced apoptosis in infected murine macrophages results in necroptosis.

    abstract：:In mice Theiler's murine encephalomyelitis virus (TMEV) persists in macrophages that eventually undergo apoptosis. TMEV infection of macrophages in culture induces apoptosis through the intrinsic pathway, restricting virus yields. We show that inhibition of TMEV-induced apoptosis leads to phosphorylation of receptor i...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2014.10.017

    authors： Son KN,Lipton HL

    更新日期：2015-01-02 00:00:00

  • AIDS pathogenesis: the role of accessory gene mutations, leading to formation of long-lived persistently infected cells and/or apoptosis-inducing HIV-1 particles.

    abstract：:Human immunodeficiency virus type 1 (HIV-1) infection indirectly induces activation-dependent apoptosis in bystander immune CD4+ T-cells, a hallmark of AIDS pathogenesis. It is well known that this pathogenetic event is significantly correlated with a high virus load. Active viral replication occurs in HIV-1 asymptoma...

    journal_title：Virus research

    pub_type： 杂志文章,评审

    doi：10.1016/s0168-1702(97)00125-1

    authors： Ikuta K,Kameoka M,Luftig RB

    更新日期：1997-12-01 00:00:00

  • Molecular analysis of the echovirus 18 prototype: evidence of interserotypic recombination with echovirus 9.

    abstract：:Echovirus 18 (EV18) is one of the echovirus serotypes associated with human diseases and in particular aseptic meningitis. To facilitate studies of the molecular epidemiology of EV18 and the evolution of enteroviruses in general, the complete nucleotide (nt) sequence was determined for the echovirus 18 prototype strai...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/s0168-1702(02)00019-9

    authors： Andersson P,Edman K,Lindberg AM

    更新日期：2002-04-23 00:00:00

  • Retrovirus RD114 p30 is bound by the extracellular matrix proteins, fibronectin and laminin.

    abstract：:Purified retrovirus RD114 p30 was found to bind to the extracellular matrix proteins, fibronectin and laminin. The purified matrix proteins were immobilized onto polystyrene and the binding of p30 was quantitated using radioiodinated proteins and enzyme immunoassay (EIA). The dissociation constants were for the p30-fi...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/0168-1702(84)90028-5

    authors： Salonen EM,Suni J,Vaheri A

    更新日期：1984-01-01 00:00:00

  • Complete genome sequence of Oryctes rhinoceros nudivirus isolated from the coconut rhinoceros beetle in Solomon Islands.

    abstract：:Oryctes rhinoceros nudivirus (OrNV) has been an effective biocontrol agent against the insect pest Oryctes rhinoceros (Coleoptera: Scarabaeidae) for decades, but there is evidence that resistance could be evolving in some host populations. We detected OrNV infection in O. rhinoceros from Solomon Islands and used Oxfor...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2020.197864

    authors： Etebari K,Filipović I,Rašić G,Devine GJ,Tsatsia H,Furlong MJ

    更新日期：2020-03-01 00:00:00

  • Interferon stimulated gene 15 promotes Zika virus replication through regulating Jak/STAT and ISGylation pathways.

    abstract：:Zika virus is an emergent arbovirus that has caused a public health emergency in South America. Zika virus infection is known to cause microcephaly and other congenital defects and Guillain-Barré syndrome. Unfortunately no direct antiviral treatments are available at present. IFN-stimulated gene 15 (ISG15) is one of t...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2020.198087

    authors： Wang Y,Ren K,Li S,Yang C,Chen L

    更新日期：2020-10-02 00:00:00

  • Complete genome sequence of a raccoon rabies virus isolate.

    abstract：:The entire genome of a mid-Atlantic raccoon strain rabies virus (RRV) isolated in Canada was sequenced; this is the second North American wildlife rabies virus isolate to be fully characterized. The overall organization and length of the genome was similar to that of other lyssaviruses. The nucleotide sequence identit...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2008.04.029

    authors： Szanto AG,Nadin-Davis SA,White BN

    更新日期：2008-09-01 00:00:00

  • Expression cloning and antigenic analysis of the nucleocapsid protein of equine arteritis virus.

    abstract：:A series of recombinant fusion proteins derived from equine arteritis virus (EAV) open reading frame (ORF) 7 have been used to define the immunoreactive region of the viral nucleocapsid (N) protein. Reactivities of recombinant N fusion proteins with post-infection equine sera in immunoblots and ELISAs indicate that th...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/0168-1702(95)00098-4

    authors： Chirnside ED,Francis PM,Mumford JA

    更新日期：1995-12-01 00:00:00

  • Characterization of a highly pathogenic avian influenza H5N1 clade 2.3.4 virus isolated from a tree sparrow.

    abstract：:The spread of H5N1 virus into a wide range of avian and mammalian species may facilitate the adaptation of the virus to human populations. In the present study, a survey of avian influenza virus in tree sparrows was performed and a HPAI H5N1 virus (A/tree sparrow/Jiangsu/1/08) was isolated. The H5N1 virus was found to...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2009.09.014

    authors： Liu Q,Ma J,Kou Z,Pu J,Lei F,Li T,Liu J

    更新日期：2010-01-01 00:00:00

  • The role of secreted glycoprotein G of equine herpesvirus type 1 and type 4 (EHV-1 and EHV-4) in immune modulation and virulence.

    abstract：:Equine herpesvirus type 1 and 4 (EHV-1 and EHV-4) are important pathogens of horses worldwide. Infection with EHV-4 usually remains restricted to the upper respiratory tract, whereas infection with EHV-1 can generalize after leukocyte-associated viremia. Here we examined whether differences in the immunomodulatory gly...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2012.07.029

    authors： Thormann N,Van de Walle GR,Azab W,Osterrieder N

    更新日期：2012-10-01 00:00:00

  • Infectious bursal disease virus infection induces macrophage activation via p38 MAPK and NF-kappaB pathways.

    abstract：:In the present study, we show that infection with infectious bursal disease virus (IBDV) causes activation of macrophages, the key cells involved in inflammatory and immune-regulatory functions. Exposure of cultured spleen macrophages (SM) from SPF chickens to IBDV resulted in the production of nitric oxide (NO). In a...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2005.11.015

    authors： Khatri M,Sharma JM

    更新日期：2006-06-01 00:00:00

  • The fibroblast growth factor homolog of Bombyx mori nucleopolyhedrovirus enhances systemic virus propagation in B. mori larvae.

    abstract：:All lepidopteran baculovirus genomes sequenced to date encode a viral fibroblast growth factor homolog (vFGF). Recently, we generated a Bombyx mori nucleopolyhedrovirus (BmNPV) mutant lacking functional vfgf and found that BmNPV vfgf contributes to virus virulence in B. mori larvae. However, the steps at which BmNPV v...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2008.06.002

    authors： Katsuma S,Horie S,Shimada T

    更新日期：2008-10-01 00:00:00

  • Correlation of cellular factors and differential scrapie prion permissiveness in ovine microglia.

    abstract：:Prion diseases are fatal neurodegenerative disorders by which the native cellular prion protein (PrPC) is misfolded into an accumulating, disease-associated isoform (PrPD). To improve the understanding of prion pathogenesis and develop effective treatments, it is essential to elucidate factors contributing to cellular...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2017.07.016

    authors： Dinkel KD,Schneider DA,Muñoz-Gutiérrez JF,McElliott VR,Stanton JB

    更新日期：2017-08-15 00:00:00

  • Use of a neural network secondary structure prediction to define targets for mutagenesis of herpes simplex virus glycoprotein B.

    abstract：:Herpes simplex virus glycoprotein B (HSV gB) is essential for penetration of virus into cells, for cell-to-cell spread of virus, and for cell-cell fusion. Every member of the family Herpesviridae has a gB homolog, underlining its importance. The antigenic structure of gB has been studied extensively, but little is kno...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/s0168-1702(98)00030-6

    authors： Norton DD,Dwyer DS,Muggeridge MI

    更新日期：1998-05-01 00:00:00

  • Enhanced immune responses against Japanese encephalitis virus using recombinant adenoviruses coexpressing Japanese encephalitis virus envelope and porcine interleukin-6 proteins in mice.

    abstract：:Japanese encephalitis is a reproductive disorder caused by Japanese encephalitis virus (JEV) in swine. Previous studies have demonstrated that recombinant adenovirus serotype 5 (Ad5) may be a potential vaccine candidate because it can express JEV envelope epitopes and induce immune responses against JEV. Still, it wil...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/j.virusres.2016.05.025

    authors： Liu H,Wu R,Liu K,Yuan L,Huang X,Wen Y,Ma X,Yan Q,Zhao Q,Wen X,Cao S

    更新日期：2016-08-15 00:00:00

  • Methylation of the polyomavirus major capsid protein VP1.

    abstract：:Polyomavirus VP1 has been shown to be modified by phosphorylation, sulfation, acetylation and hydroxylation. The major capsid protein VP1 is now shown to be modified by methylation. Addition of cycloheximide to infected cultures followed by addition of [3H-methyl]-L-methionine and subsequent immunoprecipitation, SDS-P...

    journal_title：Virus research

    pub_type： 杂志文章

    doi：10.1016/0168-1702(95)01266-4

    authors： Burton KS,Consigli RA

    更新日期：1996-02-01 00:00:00