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Replication of varicella zoster virus in Raji cells.

Abstract：

:This report provides evidence for the replication of varicella zoster virus (VZV) in Raji cells. Infection was achieved by co-cultivation of Raji cells with VZV-infected human fibroblasts. Replication of VZV, as assessed by immunofluorescence using monoclonal antibodies against VZV-glycoproteins, ranged from 18 to 24% of the cells. Electron microscopy detected complete virions within the membrane-bound cytoplasmic vesicles and free viral particles in the nuclear matrix as late as 12 days post-infection. Western blot analysis of infected Raji cells demonstrated VZV-specific glycoproteins. The availability of a VZV-susceptible cell line growing in suspension culture provides a useful model for future studies.

journal_name

Virus Res

journal_title

Virus research

authors

Cauda R,Chatterjee S,Tilden AB,Grossi CE,Whitley RJ

doi

10.1016/0168-1702(86)90080-8

subject

Has Abstract

pub_date

1986-06-01 00:00:00

pages

337-42

issue

4

eissn

0168-1702

issn

1872-7492

pii

0168-1702(86)90080-8

journal_volume

4

pub_type

杂志文章

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