Abstract：
:Fifteen stable mouse spleen cell myeloma hybrids (hybridomas) producing monoclonal antibodies to rinderpest virus proteins were produced. The specificity of these monoclonal antibodies was established by radioimmunoprecipitation followed by polyacrylamide gel analysis and immunofluorescence. Nine antibodies were specific for the surface glycoprotein H. All the nine clones showed inhibition of haemagglutination by measles virus. The antibodies from two clones (A7D2 and B2F6) neutralise infectious virus. Six clones produce antibodies reacting with the nucleocapsid protein N. Three antigenic sites designated I-III, with sites I and II partially overlapping, were topographically mapped on the H molecule by competitive binding assay. Similarly, two antigenic sites I and II were delineated on the N protein. The monoclonal antibodies were used to study the antigenic relationships of H and N proteins of rinderpest virus, measles virus and canine distemper virus.
journal_name
Virus Resjournal_title
Virus researchauthors
Bhavani K,Karande AA,Shaila MSdoi
10.1016/0168-1702(89)90091-9subject
Has Abstractpub_date
1989-04-01 00:00:00pages
331-48issue
4eissn
0168-1702issn
1872-7492pii
0168-1702(89)90091-9journal_volume
12pub_type
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