Abstract：
:In present study, we report the first complete genomic sequence of pig bovine viral diarrhea (BVD) virus, that of strain ZM-95, which is 12,220 nucleotides long and contains short 5' and 3' non-coding regions and one open reading frame encoding a large polyprotein with 28 potential N-glycosylation sites (Asn-X-Ser or Asn-X-Thr). Within the non-structural protein encoding region, no foreign nucleotide insertions was found as those usually observed for cytopathogenic BVDV-1, but close to the 3'-terminal of the capsid protein (1119-1124bp) it contains a short insertion of a six nucleotide sequence (CTCACA). Three hypervariable regions were identified in the polyprotein-encoding region, with one of them comprising a sequence motif encoding a unique five amino acid peptide HYKKK in glycoprotein E2 gene. The genomic comparison and phylogenetic analyses showed that ZM-95 should be classified into BVDV-1, but was genetically divergent from other pestiviruses sequenced to date since its highest genetic similarity was only 76.6% (with SD-1), therefore, placed as a novel subgroup of BVDV-1.
journal_name
Virus Resjournal_title
Virus researchauthors
Xu X,Zhang Q,Yu X,Liang L,Xiao C,Xiang H,Tu Cdoi
10.1016/j.virusres.2006.05.005subject
Has Abstractpub_date
2006-12-01 00:00:00pages
164-70issue
1-2eissn
0168-1702issn
1872-7492pii
S0168-1702(06)00180-8journal_volume
122pub_type
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