Abstract：
:We previously prepared neutralizing monoclonal antibody (MAb)-resistant (mar) mutant viruses using a laboratory strain feline infectious peritonitis virus (FIPV) 79-1146 (Kida et al., 1999). Mar mutant viruses are mutated several amino acids of the neutralizing epitope of Spike protein, compared with the parent strain, FIPV 79-1146. We clarified that MAb used to prepare mar mutant viruses also lost its activity to enhance homologous mar mutant viruses, strongly suggesting that neutralizing and antibody-dependent enhancing epitopes are present in the same region in the strain FIPV 79-1146. We also discovered that amino acid mutation in the neutralizing epitope reduced viral replication in monocytes/macrophages. We also demonstrated that the mutation or deletion of two nucleotides in 7b gene abrogate the virulence of strain FIPV 79-1146.
journal_name
Virus Resjournal_title
Virus researchauthors
Takano T,Tomiyama Y,Katoh Y,Nakamura M,Satoh R,Hohdatsu Tdoi
10.1016/j.virusres.2010.12.020subject
Has Abstractpub_date
2011-03-01 00:00:00pages
72-80issue
1-2eissn
0168-1702issn
1872-7492pii
S0168-1702(11)00004-9journal_volume
156pub_type
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