Abstract：
:The paramyxo- and pneumoviruses are members of the order Mononegavirales, a group of viruses with non-segmented, negative strand RNA genomes. The polymerases of these viruses are multi-functional complexes, capable of transcribing subgenomic capped and polyadenylated mRNAs and replicating the genome. Although there is no native structure available for any complete paramyxo- or pneumovirus polymerase, functional and structural studies of a fragment of a pneumovirus polymerase protein and mutation analyses and resistance profiling of small-molecule inhibitors have generated a wealth of mechanistic information. This review integrates these data with the structure of a related polymerase, identifying similarities, differences, gaps in knowledge, and avenues for antiviral drug development.
journal_name
Virus Resjournal_title
Virus researchauthors
Fearns R,Plemper RKdoi
10.1016/j.virusres.2017.01.008subject
Has Abstractpub_date
2017-04-15 00:00:00pages
87-102eissn
0168-1702issn
1872-7492pii
S0168-1702(16)30734-1journal_volume
234pub_type
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