Abstract:
:Dengue virus (DENV) infection associates with renal disorders. Patients with dengue hemorrhagic fever and acute kidney injury have a high mortality rate. Increased levels of cytokines may contribute to the pathogenesis of DENV-induced kidney injury. Currently, molecular mechanisms how DENV induces kidney cell injury has not been thoroughly investigated. Excessive cytokine production may be involved in this process. Using human cytokine RT(2) Profiler PCR array, 14 genes including IP-10, RANTES, IL-8, CXCL-9 and MIP-1β were up-regulated more than 2 folds in DENV-infected HEK 293 cells compared to that of mock-infected HEK 293 cells. In the present study, RANTES was suppressed by the NF-κB inhibitor, compound A (CpdA), in DENV-infected HEK 293 cells implying the role of NF-κB in RANTES expression. Chromatin immunoprecipitation (ChIP) assay showed that NF-κB binds more efficiently to its binding sites on the RANTES promoter in NS5-transfected HEK 293 cells than in HEK 293 cells expressing the vector lacking NS5 gene. To further examine whether the NS5-activated RANTES promoter is mediated through NF-κB, the two NF-κB binding sites on the RANTES promoter were mutated and this promoter was coupled to the luciferase cDNA. The result showed that when both binding sites of NF-κB in the RANTES promoter were mutated, the ability of NS5 to induce the luciferase activity was significantly decreased. Therefore, DENV NS5 activates RANTES production by increasing NF-κB binding to its binding sites on the RANTES promoter.
journal_name
Virus Resjournal_title
Virus researchauthors
Khunchai S,Junking M,Suttitheptumrong A,Kooptiwut S,Haegeman G,Limjindaporn T,Yenchitsomanus PTdoi
10.1016/j.virusres.2014.12.007subject
Has Abstractpub_date
2015-02-02 00:00:00pages
92-100eissn
0168-1702issn
1872-7492pii
S0168-1702(14)00512-7journal_volume
197pub_type
杂志文章相关文献
VIRUS RESEARCH文献大全abstract::Mosquito-borne alphaviruses are disseminated globally and cause febrile illness in humans and animals. Since the prevalence and diversity of alphaviruses has not been previously investigated in Zambia, reverse transcription PCR was employed as a broad-spectrum approach for the detection of alphaviruses in mosquitoes. ...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2018.04.005
更新日期:2018-05-02 00:00:00
abstract::Fowlpox virus (FWPV) is currently used as a vector to express foreign genes of various poultry and mammalian pathogens. However, due to limited information available about the primary structure of FWPV promoters required for an optimal transcriptional efficiency, the full potential of FWPV as an expression vector has ...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2005.08.017
更新日期:2006-03-01 00:00:00
abstract::The hepatitis C virus (HCV) nonstructural protein 3 (NS3) is essential for the processing of the HCV polyprotein, the replication of HCV RNA, and to short circuit innate immunity signaling. NS3 contains an N-terminal domain with protease activity and a C-terminal domain with helicase activity. The two domains communic...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2012.07.007
更新日期:2012-10-01 00:00:00
abstract::Single-cell sequencing (SCS) has emerged as a valuable tool to study cellular heterogeneity in diverse fields, including virology. By studying the viral and cellular genome and/or transcriptome, the dynamics of viral infection can be investigated at single cell level. Most studies have explored the impact of cell-to-c...
journal_title:Virus research
pub_type: 杂志文章,评审
doi:10.1016/j.virusres.2016.10.016
更新日期:2017-07-15 00:00:00
abstract::Nervous necrosis virus (NNV) belongs to the genus Betanodavirus (Nodaviridae). It is highly pathogenic to various marine fishes. Here, we investigated the antigenicity changes of cultured NNV suspensions during 14days of dialyses using a dialysis tube at 1.4×10(4) molecular weight cut off (MWCO) in three different buf...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2016.07.002
更新日期:2016-09-02 00:00:00
abstract::Orf virus infection causes a contagious pustular dermatitis characterized by extensive vascular changes that have been linked to a virally encoded vascular endothelial growth factor (VEGF). The VEGF genes of different strains of orf virus can vary extensively in amino acid sequence. Functional analyses of two major va...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2007.04.018
更新日期:2007-09-01 00:00:00
abstract::In order to clarify the genetic relationships and dynamics of rabies viruses that are epidemic in Indonesia, we determined and analyzed 1307 nucleotides of nucleoprotein genes of 34 rabies field isolates collected from Sumatra, Java, Kalimantan, Sulawesi and Flores islands. Results of phylogenetic analysis indicated t...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2008.03.001
更新日期:2008-07-01 00:00:00
abstract::We have rescued a transfectant influenza virus, NA/TAIL(-), whose neuraminidase (NA) protein lacks the predicted cytoplasmic tail. The virus was attenuated (one log10 reduction) both in tissue culture and in mouse lungs. Attenuation correlated with a 50% reduction of the level of NA in infected cells and levels of inc...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/0168-1702(95)00017-k
更新日期:1995-06-01 00:00:00
abstract::MicroRNAs play vital roles in regulating the battle between pathogens and host cells during viral challenging. MiR-4331 aggravates transmissible gastroenteritis virus (TGEV) -induced mitochondrial damage, also suppresses transcription of TGEV gene 7 via targeting cellular CDCA7. Otherwise, miR-4331-5p affects H1N1/200...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2020.198064
更新日期:2020-09-01 00:00:00
abstract::The rabies viruses that circulate in Arctic countries and in much of northern and central Asia are phylogenetically closely related and collectively referred to as the Arctic/Arctic-like (AL) lineage. The emergence and spread of this lineage is of significant interest given that rabies remains a serious zoonotic disea...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2011.10.026
更新日期:2012-01-01 00:00:00
abstract::MicroRNAs (miRNAs) constitute an important class of non-coding RNA implicated in gene expression regulation. More than 1900 miRNA molecules have been identified in humans and their modulation during viral infection and it is recognized to play a role in latency regulation or in establishing an antiviral state. The liv...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2014.11.010
更新日期:2015-01-22 00:00:00
abstract::Viruses have evolved unique strategies and mechanisms to recruit ribosomes to ensure continued translation of their viral RNA during infection. The Dicistroviridae family of invertebrate viruses contains an unusual internal ribosome entry site (IRES), which can directly recruit ribosomes in the absence of initiation f...
journal_title:Virus research
pub_type: 杂志文章,评审
doi:10.1016/j.virusres.2005.10.011
更新日期:2006-07-01 00:00:00
abstract::This review focuses on new or improved technologies currently being applied, or likely to be applied in the future, to worldwide research on plant virus epidemiology. Recent technological advances and innovations provide many opportunities to improve understanding of the way diverse types of plant virus epidemics deve...
journal_title:Virus research
pub_type: 杂志文章,评审
doi:10.1016/j.virusres.2013.11.003
更新日期:2014-06-24 00:00:00
abstract::Diagnostic methods allowing for rapid identification of pathogens are crucial for controlling and preventing dissemination after disease outbreaks as well as for use in surveillance programs. For arboviruses, detection of the presence of virus in their arthropod hosts is important for monitoring of viral activity and ...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2012.07.019
更新日期:2012-10-01 00:00:00
abstract::Mammalian orthoreovirus (MRV) is the type species of the genus Orthoreovirus and causes a range of significant respiratory, nervous or enteric diseases in humans and animals. In 2016 a farmed white-tailed deer (Odocoileus virginianus) fawn became ill, displaying clinical signs of lethargy, dehydration, and profuse fou...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2019.197642
更新日期:2019-09-01 00:00:00
abstract::Herpes simplex virus type 1 (HSV-1) establishes a lifelong latency in the neurons of its host. Sporadically, the latent virus reactivates and spreads back to the original site of infection and causes recrudescent diseases. The only gene actively transcribed during neuronal latency is the latency associated transcript ...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2004.08.011
更新日期:2005-03-01 00:00:00
abstract::Viruses frequently spread among cells or hosts in groups, with multiple viral genomes inside the same infectious unit. These collective infectious units can consist of multiple viral genomes inside the same virion, or multiple virions inside a larger structure such as a vesicle. Collective infectious units deliver mul...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2019.03.013
更新日期:2019-05-01 00:00:00
abstract::Hepatitis delta virus (HDV) is an RNA virus and eight clades of HDV have been identified. HDV clade 3 (HDV-3) is isolated only in the northern area of South America. The outcome of HDV-3 infection is associated with severe fulminant hepatitis. Variations in the large delta antigen (LDAg) between HDV clade 1 (HDV-1) an...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2012.08.021
更新日期:2012-12-01 00:00:00
abstract::I have observed a relationship between GC content in coding sequences of RNA viruses and their genome polarity. Positive-stranded RNA viruses have significantly higher GC contents than negative-stranded RNA viruses. Coding sequences of all negative-stranded RNA viruses are biased toward high A in coding strands (high ...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2004.10.004
更新日期:2005-04-01 00:00:00
abstract::Persistent infections with mumps virus were established in human B-lymphoid cell line Akata and in the human chronic myelogenous leukaemia cell line K562. Even after IFN treatment a drastic decrease in STAT-1alpha (signal transducers and activators of transcription-1alpha), STAT-2 and p48 (ISGF-3gamma: IFN-stimulated ...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/s0168-1702(99)00114-8
更新日期:1999-12-15 00:00:00
abstract::The spread of H5N1 virus into a wide range of avian and mammalian species may facilitate the adaptation of the virus to human populations. In the present study, a survey of avian influenza virus in tree sparrows was performed and a HPAI H5N1 virus (A/tree sparrow/Jiangsu/1/08) was isolated. The H5N1 virus was found to...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2009.09.014
更新日期:2010-01-01 00:00:00
abstract::Apoptosis is an important mechanism of human immunodeficiency virus type 1 (HIV-1)-induced T-cell depletion. Our recent findings revealed mitogenic stimulation-dependent apoptosis induction in healthy donor-derived peripheral blood T-lymphocytes after adsorption with defective HIV-1 particles through acquirement by a ...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/s0168-1702(98)00052-5
更新日期:1998-07-01 00:00:00
abstract::To characterize the genomic mutations of hepatitis E virus (HEV) during consecutive passages associated with adaptation to growth in cell culture, a cloned genotype 3 HEV [pJE03-1760F/wt, starting virus (SV)] was passaged 10 times in A549 cells, and the entire genomic sequence of the passage 10 (P10) progeny was deter...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2016.07.011
更新日期:2016-09-02 00:00:00
abstract::Human respiratory syncytial virus (HRSV) P protein, 241 amino acid long, is a structural homotetrameric phosphoprotein. Viral transcription and replication processes are dependent on functional P protein interactions inside viral ribonucleoprotein complexes (RNPs). Binding capacity to RNPs proteins and transcription a...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2007.11.013
更新日期:2008-03-01 00:00:00
abstract::In the past few decades, dengue has spread rapidly and is an emerging disease in China. An unexpected dengue outbreak occurred in Xishuangbanna, Yunnan, China, resulting in 1331 patients in 2013. In order to obtain the complete genome information and perform mutation and evolutionary analysis of causative agent relate...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2017.06.015
更新日期:2017-06-15 00:00:00
abstract::The nucleotide sequences of the nucleoprotein (NP) genes of fowl plague virus (FPV) and of a temperature-sensitive (ts) mutant (ts81) derived therefrom have been determined. The ts81-NP nucleotide sequence possesses a single nucleotide substitution in comparison to the wild type. This causes an amino acid exchange at ...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/0168-1702(89)90058-0
更新日期:1989-02-01 00:00:00
abstract::Hepatitis delta virus (HDV) requires the surface antigens of hepatitis B virus (HBV) for packaging and transmission, but replicates its RNA in an HBV-independent fashion. HDV contains a 1.7-kb circular RNA genome that is folded into an unbranched rod-like structure via intramolecular base-pairing, and possesses ribozy...
journal_title:Virus research
pub_type: 杂志文章,评审
doi:10.1016/j.virusres.2007.01.003
更新日期:2007-08-01 00:00:00
abstract::Over the past three decades diseases caused by whitefly-transmitted geminiviruses (begomoviruses) have emerged to be important constraints to the production of solanaceous crops, particularly tomato (Solanum lycopersicum) and peppers (Capsicum spp.), in many tropical and subtropical regions of the world. The most stud...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2013.12.026
更新日期:2014-06-24 00:00:00
abstract::We recently described a giant double stranded DNA virus called Mimivirus, isolated from amoebae, which might represent a new pneumonia-associated human pathogen. Its unique morphological and genomic characteristics allowed us to propose Mimivirus as a member of a new distinct Nucleocytoplasmic Large DNA viruses family...
journal_title:Virus research
pub_type: 杂志文章,评审
doi:10.1016/j.virusres.2005.07.011
更新日期:2006-04-01 00:00:00
abstract::p29, a newly identified Kaposi's sarcoma-associated herpesvirus (KSHV) protein, is the product of ORF67, the positional homolog of the conserved herpesvirus protein UL34. Like its homologues in other herpesviruses, p29 is expressed early during viral lytic cycle, and is localized on the nuclear rim. Upon chemical indu...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2013.04.001
更新日期:2013-08-01 00:00:00