Abstract：
:Single-cell sequencing (SCS) has emerged as a valuable tool to study cellular heterogeneity in diverse fields, including virology. By studying the viral and cellular genome and/or transcriptome, the dynamics of viral infection can be investigated at single cell level. Most studies have explored the impact of cell-to-cell variation on the viral life cycle from the point of view of the virus, by analyzing viral sequences, and from the point of view of the cell, mainly by analyzing the cellular host transcriptome. In this review, we will focus on recent studies that use single-cell sequencing to explore viral diversity and cell variability in response to viral replication.
journal_name
Virus Resjournal_title
Virus researchauthors
Rato S,Golumbeanu M,Telenti A,Ciuffi Adoi
10.1016/j.virusres.2016.10.016subject
Has Abstractpub_date
2017-07-15 00:00:00pages
55-68eissn
0168-1702issn
1872-7492pii
S0168-1702(16)30388-4journal_volume
239pub_type
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