Stimulating effect of heat shock on the early stage of human cytomegalovirus replication cycle.

Abstract:

:The effect of mild heat shock on the replication of human cytomegalovirus (HCMV) was studied in human embryo fibroblasts. Treatment of cell cultures at 44 degrees C for 10 min just before infection or at 24 h post infection (p.i.) shortened HCMV eclipse period and enhanced viral replication, while heat shock performed at 48 h p.i. had no effect on the HCMV replication cycle. Study of HCMV-induced early and late antigens confirmed that the cellular response to heat shock influences HCMV replication in the early stage of the viral replication cycle.

journal_name

Virus Res

journal_title

Virus research

authors

Zerbini M,Musiani M,La Placa M

doi

10.1016/0168-1702(86)90070-5

subject

Has Abstract

pub_date

1986-12-01 00:00:00

pages

211-6

issue

3

eissn

0168-1702

issn

1872-7492

pii

0168-1702(86)90070-5

journal_volume

6

pub_type

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