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MicroRNA-4331-5p promotes FMDV replication through inhibiting interferon pathways in PK-15 cells.

Abstract：

:MicroRNAs play vital roles in regulating the battle between pathogens and host cells during viral challenging. MiR-4331 aggravates transmissible gastroenteritis virus (TGEV) -induced mitochondrial damage, also suppresses transcription of TGEV gene 7 via targeting cellular CDCA7. Otherwise, miR-4331-5p affects H1N1/2009 influenza A virus replication by targeting viral HA and NS. However, whether microRNA ssc-miR-4331-5p (miR-4331-5p) regulates foot and mouth virus (FMDV) replication remains unclear. To explore the role of miR-4331-5p in FMDV infection, we detected the expression level of miR-4331-5p in porcine kidney (PK-15) cells. The results showed that FMDV infection directly upregulates miR-4331-5p expression, while transfection of mimics or inhibitor of miR-4331-5p promotes or inhibits FMDV replication. Further investigation clearly showed that miR-4331-5p increases FMDV replication through inhibiting type I interferon pathways. These data demonstrate that miR-4331-5p plays an important role in regulating FMDV replication.

journal_name

Virus Res

journal_title

Virus research

authors

Ren T,Wang Y,Chen H,Wang K,Gao X,Liu L,Zhang Y,Sun Y

doi

10.1016/j.virusres.2020.198064

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

198064

eissn

0168-1702

issn

1872-7492

pii

S0168-1702(20)30123-4

journal_volume

286

pub_type

杂志文章

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