Abstract：
:Hamster polyomavirus (HaPyV) major capsid protein VP1 based chimeric virus-like particles (VLPs) carrying model GP33 CTL epitope derived from Lymphocytic choriomeningitis virus (LCMV) were generated in yeast and examined for their capability to induce CTL response in mice. Chimeric VP1-GP33 VLPs were effectively processed in antigen presenting cells in vitro and in vivo and induced antigen-specific CD8+ T cell proliferation. Mice immunized only once with VP1-GP33 VLPs without adjuvant developed an effective GP33-specific memory T cell response: 70% were fully and 30% partially protected from LCMV infection. Moreover, aggressive growth of tumors expressing GP33 was significantly delayed in these mice in vivo. Therefore, HaPyV VP1-derived VLP harboring CTL epitopes are attractive vaccine candidates for the induction of insert-specific CTL immune response.
journal_name
Virus Resjournal_title
Virus researchauthors
Mazeike E,Gedvilaite A,Blohm Udoi
10.1016/j.virusres.2011.08.003subject
Has Abstractpub_date
2012-01-01 00:00:00pages
2-10issue
1eissn
0168-1702issn
1872-7492pii
S0168-1702(11)00290-5journal_volume
163pub_type
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