Abstract：
:Vaccines against parainfluenza (PIV) and respiratory syncytial viruses (RSV) that are currently being developed include both live and subunit vaccines. Candidate live PIV vaccines that have been found to be attenuated and efficacious in rodents or primate models are (1) cold-adapted, temperature-sensitive mutants of PIV-type 3 that have been serially passaged at low temperature (20 degrees C) in simian kidney tissue culture; (2) protease-activation mutants (PIV-1-Sendai), which have mutations that decrease the cleavability of their F glycoprotein by host cell protease; (3) an animal virus, bovine PIV-3 virus, which is antigenically related to the human PIV-3 virus, and (4) vaccinia recombinant viruses bearing RSV or PIV-3 glycoproteins. Subunit RSV and PIV-3 viruses are being produced and evaluated as immunogens. A major concern with these vaccines is the possibility of disease potentiation following virus infection as occurred previously with formalin-inactivated measles and RSV vaccines. Studies indicate that PIV-3 and RSV glycoprotein vaccines are immunogenic and efficacious in animals but insufficient data exist to estimate their capacity to potentiate disease. However, since a cotton rat model is available to detect potentiated disease resulting from infection of cotton rats previously immunized with formalin-inactivated RSV vaccine, it is now possible to systematically evaluate new vaccines in experimental animals for disease potentiation before studies are initiated in humans. It is likely within the next several years that one or more of these PIV or RSV vaccines will be tested in humans for safety and immunogenicity.
journal_name
Virus Resjournal_title
Virus researchauthors
Murphy BR,Prince GA,Collins PL,Van Wyke Coelingh K,Olmsted RA,Spriggs MK,Parrott RH,Kim HW,Brandt CD,Chanock RMdoi
10.1016/0168-1702(88)90063-9subject
Has Abstractpub_date
1988-08-01 00:00:00pages
1-15issue
1eissn
0168-1702issn
1872-7492pii
0168-1702(88)90063-9journal_volume
11pub_type
杂志文章,评审相关文献
VIRUS RESEARCH文献大全abstract：:Vaccine formulation can influence cytokine and disease patterns in mice following respiratory syncytial virus (RSV) challenge. The influence of different live and killed dual-vaccine combinations on subsequent immune responses was investigated. BALB/c mice received either killed followed by killed (KV/KV), killed foll...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2003.10.009
更新日期：2004-01-01 00:00:00
abstract：:Typically plasma viremia is controlled in macaques challenged with R5 tropic SHIV162P3 during the chronic phase of infection. However, in a few infected animals it sustains for a prolonged period. Persistent plasma viremia in two such macaques led to a rapid decline of CD4+ T-cells in blood leading to the induction of...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2010.04.006
更新日期：2010-08-01 00:00:00
abstract：:Central nervous system (CNS) infection with herpes simplex virus (HSV)-1 triggers neuroinflammatory responses leading to peripheral immune cell infiltration into the brain. Previous in vitro studies from our laboratory, using primary human brain cells, implicated microglia as the cellular source of infection-induced c...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2006.03.009
更新日期：2006-10-01 00:00:00
abstract：:Echovirus 18 (EV18) is one of the echovirus serotypes associated with human diseases and in particular aseptic meningitis. To facilitate studies of the molecular epidemiology of EV18 and the evolution of enteroviruses in general, the complete nucleotide (nt) sequence was determined for the echovirus 18 prototype strai...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(02)00019-9
更新日期：2002-04-23 00:00:00
abstract：:A new virus termed Rosellinia necatrix megabirnavirus 2 (RnMBV2) was molecularly and biologically characterized. RnMBV2 was originally harbored in isolate W8 of R. necatrix co-infected with the previously reported virus Rosellinia necatrix partitivirus 1 (RnPV1). RnMBV2 has molecular features similar and different fro...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2015.12.009
更新日期：2016-07-02 00:00:00
abstract：:As agricultural acreage expanded and came to dominate landscapes across the world, viruses gained opportunities to move between crop and wild native plants. In the Midwestern USA, virus exchange currently occurs between widespread annual Poaceae crops and remnant native perennial prairie grasses now under consideratio...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2017.07.006
更新日期：2017-09-15 00:00:00
abstract：:Murine acquired immunodeficiency syndrome (MAIDS) induced by a defective LP-BM5 murine leukemia virus (MuLV) produces hematopoietic cytopenias similar to HIV in patients with AIDS. The pathogenesis of MAIDS induced cytopenias remains obscure; however, direct retroviral infection of bone marrow stroma has been implicat...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2005.03.027
更新日期：2005-10-01 00:00:00
abstract：:The uptake of porcine parvovirus (PPV) into host cells, permissive or nonpermissive for PPV replication, was monitored by autoradiography, immunofluorescent microscopy, and dual parameter flow cytometry. While both permissive and nonpermissive cells selectively took up the light (activated) form of the virus from a mi...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(88)90054-8
更新日期：1988-04-01 00:00:00
abstract：:This review compares the well-studied RNase H activities of human immunodeficiency virus, type 1 (HIV-1) and Moloney murine leukemia virus (MoMLV) reverse transcriptases. The RNase H domains of HIV-1 and MoMLV are structurally very similar, with functions assigned to conserved subregions like the RNase H primer grip a...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/j.virusres.2007.12.007
更新日期：2008-06-01 00:00:00
abstract：:Employing the yeast two-hybrid system, the Tat protein of the human immunodeficiency virus (HIV) was shown to interact with a region spanning the EGF-like repeats 1-6 of the mouse Notch1, the human Notch2 and the Drosophila Notch. This observation was confirmed in mammalian cells by demonstrating an interaction betwee...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2003.08.016
更新日期：2003-12-01 00:00:00
abstract：:CVB3 virus tropism and tissue access are modulated by cardiac microvascular endothelial cells (CMVECs) in the context of microvasculature. This study was designed to examine biological behaviors of CMVECs following CVB3 infection and its possible effects on cardiac remodeling. Data demonstrated that CVB3 increased cas...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2012.07.027
更新日期：2012-10-01 00:00:00
abstract：:Nearly 100 years after its discovery poliovirus remains one of most thoroughly studied and best understood virus models for the molecular virologist. While poliovirus has been of vital importance for our insight into picornavirus biology at the cellular and biochemical level, it is ironic to note that, due to the earl...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/j.virusres.2005.04.008
更新日期：2005-08-01 00:00:00
abstract：:Influenza A virus replication and packaging is mediated by cis-acting signals, which are located at the 3' and the 5' end of the viral segments. The terminal residues can be divided into conserved and nonconserved residues. We have constructed a mutant influenza A/WSN/33 virus, which contains multiple mutations in the...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(96)01335-4
更新日期：1996-09-01 00:00:00
abstract：:Singapore grouper iridovirus (SGIV) is a large double-stranded DNA virus that is a major threat to grouper aquaculture. The pathogenesis of SGIV is not well understood so far. Previous studies have revealed that ICP18, an immediate early protein encoded by SGIV ORF086R gene, promotes viral replication by regulating ce...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2020.198218
更新日期：2021-01-02 00:00:00
abstract：:Marek's disease virus (MDV) is an oncogenic herpesvirus that causes a disease in chickens characterized by tumor formation and immunosuppression. In this paper, we identified differentially expressed proteins in the bursa of Fabricius of chickens infected with the highly virulent MDV strain RB1B, using two-dimensional...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2010.08.010
更新日期：2010-11-01 00:00:00
abstract：:A flow cytometric assay that measures binding of human T-lymphotropic virus type 1 (HTLV-1) virions to target cells was used to investigate the binding process and to screen for compounds affecting viral binding. Results showed that adenosine receptor type 2 antagonists effectively inhibit viral binding at concentrati...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(03)00048-0
更新日期：2003-05-01 00:00:00
abstract：:A study of the evolutionary relationships of GLRaV-4,-5,-6 and -9, and two new Ampelovirus isolates (GLRaV-Pr and -De) related to grapevine leafroll disease was conducted based on molecular variability, positive selection analysis and maximum likelihood phylogenetic reconstructions. Sequences corresponding to the N-te...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2008.02.015
更新日期：2008-07-01 00:00:00
abstract：:Recently, we described the isolation and characterisation of the novel lepidopteran transposon TCp3.2, which was found to be inserted into the genome of a spontaneous mutant of the baculovirus Cydia pomonella granulovirus (CpGV). Transposon TCp3.2, which is a member of the Tcl/mariner superfamily, is an apparently def...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(97)00066-x
更新日期：1997-08-01 00:00:00
abstract：:The molecular mechanism involved in cytopathogenicity of rabies virus has not been fully elucidated yet. A fixed rabies virus Nishigahara strain does not induce clear cytopathic effect (CPE) in mouse neuroblastoma (NA) cells, whereas Ni-CE strain, which was established after 100 passages of Nishigahara strain in chick...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2008.05.011
更新日期：2008-10-01 00:00:00
abstract：:Previous investigations suggest that the divergence of the group I alphabaculoviruses was later than that of the group II alphabaculoviruses, however, there is no quantitative data to support this hypothesis. To examine this theory, the evolutionary rates of the 30 core genes that are conserved among all baculoviruses...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2009.01.015
更新日期：2009-06-01 00:00:00
abstract：:The recent discovery of a wide range of henipavirus-like viruses circulating in Megabats in Africa raises the question as to the zoonotic potential of these pathogens given the high human mortality rates seen with their pathogenic relatives Nipah virus and Hendra virus. In the absence of cultured infectious African He...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2014.01.003
更新日期：2014-03-06 00:00:00
abstract：:In recent years, the spread of Duck Hepatitis A Viruses (DHAVs) has represented a serious threat and significant economic impact in duck industry of China. The sixteen reported DHAV isolates (15 DHAV-1 strains and one DHAV-3) were identified from infected ducks with clinical symptoms in China between 2009 and 2012. In...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2013.10.007
更新日期：2013-12-26 00:00:00
abstract：:Purified retrovirus RD114 p30 was found to bind to the extracellular matrix proteins, fibronectin and laminin. The purified matrix proteins were immobilized onto polystyrene and the binding of p30 was quantitated using radioiodinated proteins and enzyme immunoassay (EIA). The dissociation constants were for the p30-fi...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(84)90028-5
更新日期：1984-01-01 00:00:00
abstract：:The paramyxo- and pneumoviruses are members of the order Mononegavirales, a group of viruses with non-segmented, negative strand RNA genomes. The polymerases of these viruses are multi-functional complexes, capable of transcribing subgenomic capped and polyadenylated mRNAs and replicating the genome. Although there is...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/j.virusres.2017.01.008
更新日期：2017-04-15 00:00:00
abstract：:We have used vesicular stomatitis virus (VSV) to determine the cost of antiserum resistance during escape from a polyclonal immune response. Replication of VSV in the presence of polyclonal antiserum resulted in the selection of antibody-escape mutants, as shown by increased fitness in the presence of antiserum and by...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2004.06.007
更新日期：2005-01-01 00:00:00
abstract：:Partial nucleotide sequences of the haemagglutinin (H) gene of 18 measles viruses isolated in the Gambia during 1994 and 1995 show a high degree of homology (> 98.5%) when compared with each other. These sequences form a cluster distinct from measles viruses isolated from other geographic regions and from the sequence...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(96)01434-7
更新日期：1997-05-01 00:00:00
abstract：:Sequence analyses of VP3 gene segments of Wongorr virus isolates from the Northern Territory of Australia were compared with the cognate gene segments from Picola and Paroo River viruses. Previous serological investigations had demonstrated some relationships between these viruses, however VP3 gene sequence and phylog...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(96)01344-5
更新日期：1996-10-01 00:00:00
abstract：:Chicken anemia virus (CAV) is one of the commercially important diseases of poultry worldwide. In Egypt, CAV has been reported to be a potential threat to the commercial poultry sectors. Hence, this study was aimed at isolation and full genomic analysis of CAVs circulating in chicken populations in different geographi...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2018.05.008
更新日期：2018-06-02 00:00:00
abstract：:A cell-free system was developed to study the replication of simian rotavirus SA11. The components of the system included (i) subviral particles prepared from infected cells to template the synthesis of viral RNA and (ii) an mRNA-dependent rabbit reticulocyte lysate to support protein synthesis. Based upon nuclease-se...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(86)90071-7
更新日期：1986-12-01 00:00:00
abstract：:A comprehensive phylogenetic study based on the hemagglutinin (H) protein of all known African measles virus (MV) isolates is presented. The study includes 64 new H gene sequences from Ghana. Nigeria and South Africa as well as viruses from Zambia and The Gambia for which only incomplete sequencing data were available...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(99)00072-6
更新日期：1999-07-01 00:00:00
