Abstract：
:The uptake of porcine parvovirus (PPV) into host cells, permissive or nonpermissive for PPV replication, was monitored by autoradiography, immunofluorescent microscopy, and dual parameter flow cytometry. While both permissive and nonpermissive cells selectively took up the light (activated) form of the virus from a mixed population of heavy and light infectious virions, the virus was only replicated in the permissive cell cultures. Transfection of permissive and nonpermissive cells with purified PPV genome was only successful with the permissive host cells. These results suggest that the restriction of PPV to certain host cells is the result of intracellular events rather than selective binding of virus to the host cell surface.
journal_name
Virus Resjournal_title
Virus researchauthors
Ridpath JF,Mengeling WLdoi
10.1016/0168-1702(88)90054-8subject
Has Abstractpub_date
1988-04-01 00:00:00pages
17-27issue
1eissn
0168-1702issn
1872-7492pii
0168-1702(88)90054-8journal_volume
10pub_type
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