Abstract：
:RNA viruses exist as quasispecies containing many variants within their populations because of the error prone nature of viral RNA-dependent RNA polymerases. Quasispecies are not a simple collection of individual variants. Instead, internal interactions among variants provide quasispecies with unique evolvability. An example is 'cooperation' between wild-type and defective measles viruses, in which co-existence of a wild-type and a mutant genome produces a new phenotype. Such internal interactions presuppose efficient co-transmission of multiple genomes to the same cell, which is achieved by polyploid virions of some virus families or by a high multiplicity of infection. Recent studies have revealed that multiple viral genomes can also be transmitted simultaneously ('bloc transmission') by other mechanisms, strengthening the concept of internal interactions among viral quasispecies. Elucidation of the mechanisms of virus evolution, including internal interactions and bloc transmission, may provide rational strategies to solve such important problems of virus infections as drug-resistance, immune evasion, and acquisition of the new tropism and host range.
journal_name
Virus Resjournal_title
Virus researchauthors
Shirogane Y,Watanabe S,Yanagi Ydoi
10.1016/j.virusres.2019.02.015subject
Has Abstractpub_date
2019-04-15 00:00:00pages
68-73eissn
0168-1702issn
1872-7492pii
S0168-1702(18)30587-2journal_volume
264pub_type
杂志文章,评审相关文献
VIRUS RESEARCH文献大全abstract：:Lepidopteran nucleopolyhedroviruses have distinct viral tissue tropisms in host larvae. We previously identified the Bm8 gene of Bombyx mori nucleopolyhedrovirus (BmNPV), the product of which inhibits viral propagation in the middle silk gland (MSG). However, it is unknown whether this inhibitory function of the Bm8 p...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2018.03.011
更新日期：2018-04-02 00:00:00
abstract：:Cold-passaged (CP) mutants derived from the JS strain of wild type wt parainfluenza type 3 virus (PIV3) are being evaluated as candidate live virus vaccines. The wt virus was serially passaged 45 times at low temperature and mutant clones with the cold-adapted (CA), temperature-sensitive (ts), and attenuation (ATT) ph...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(92)90049-f
更新日期：1992-03-01 00:00:00
abstract：:The diagnosis of infectious diseases is sometimes difficult because of extensive immunological cross-reactivity between related viral antigens. On the path of constructing sero-specific antigens, we have identified residues involved in sero-specific and cross-reactive recognition of the nucleocapsid proteins (NPs) of ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2008.06.003
更新日期：2008-10-01 00:00:00
abstract：:To investigate the evolutionary origins of proteins encoded by the Poxviridae family of viruses, we examined all poxvirus protein coding genes using a method of characterizing and visualizing the similarity between these proteins and taxonomic subsets of proteins in GenBank. Our analysis divides poxvirus proteins into...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2009.05.006
更新日期：2009-09-01 00:00:00
abstract：:Partial nucleotide sequences of the haemagglutinin (H) gene of 18 measles viruses isolated in the Gambia during 1994 and 1995 show a high degree of homology (> 98.5%) when compared with each other. These sequences form a cluster distinct from measles viruses isolated from other geographic regions and from the sequence...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(96)01434-7
更新日期：1997-05-01 00:00:00
abstract：:We have determined the post-translational modifications of the major capsid protein, L1 of human papillomavirus (HPV) type 6b. Since this virus cannot be cultured in the laboratory to obtain sufficient material for a study, a recombinant L1 protein produced in a vaccinia virus expression system was used in this invest...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(98)00117-8
更新日期：1999-04-01 00:00:00
abstract：:In order to investigate the functional properties of the UL56 gene of herpes simplex virus type 1 (HSV-1), it was necessary to express the UL56 protein in vitro. The DNA sequences corresponding to the open reading frame of the UL56 gene of HSV-1 strain F were amplified from genomic viral DNA by PCR using primers corre...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(94)90017-5
更新日期：1994-07-01 00:00:00
abstract：BACKGROUND:Psittacine beak and feather disease affects parrots resulting in an immunosuppressive disease that is often characterized by an abnormal shape and growth of the animal's beak, feathers, and claws. Beak and feather disease virus (BFDV) is a single-stranded circular DNA virus and is classified as a member of t...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2015.12.001
更新日期：2016-02-02 00:00:00
abstract：:Over the past three decades diseases caused by whitefly-transmitted geminiviruses (begomoviruses) have emerged to be important constraints to the production of solanaceous crops, particularly tomato (Solanum lycopersicum) and peppers (Capsicum spp.), in many tropical and subtropical regions of the world. The most stud...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2013.12.026
更新日期：2014-06-24 00:00:00
abstract：:Canine distemper virus (CDV) is a major pathogen of dogs and represents a serious threat to both unvaccinated and vaccinated animals. This study surveyed dogs with or without clinical signs related to canine distemper from different regions of Brazil from 2008 to 2012. A total of 155 out of 386 animals were found to b...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2013.12.024
更新日期：2014-02-13 00:00:00
abstract：:Swine influenza virus (SIV) is not only an important respiratory pathogen in pigs but also a threat to human health. The pandemic influenza A(H1N1)pdm09 virus likely originated in swine through reassortment between a North American triple reassortant and Eurasian avian-like SIV. The North American triple reassortant v...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2013.01.004
更新日期：2013-05-01 00:00:00
abstract：:Although a significant progress has been achieved on dsRNA mediated anti-virus strategy development, there is still no effective means to control the virulent white spot syndrome virus (WSSV). Six double-stranded RNAs specific to different essential genes of WSSV (ie1, ie3, pol (DNA polymerase), rr2 (ribonucleotide re...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2009.06.018
更新日期：2009-10-01 00:00:00
abstract：:An account is given of progress during the last 30 years in knowledge of the epidemiology of diseases caused by aphid-borne viruses in seed potato production areas of northern Europe. During this period, Potato leafroll virus (PLRV) and strains of Potato virus Y (PVY(O), PVY(N)) were consistently the most prevalent an...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/s0168-1702(00)00186-6
更新日期：2000-11-01 00:00:00
abstract：:Numerous host factors are required for the efficient replication of rotavirus, including the activation and inactivation of several cell signaling pathways. One of the cellular structures that are reorganized during rotavirus infection is the actin cytoskeleton. In this work, we report that the dynamics of the actin m...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2019.01.003
更新日期：2019-04-02 00:00:00
abstract：:The surface antigen gene region from five chronic hepatitis B virus (HBV) infected chimpanzees was amplified by PCR and the sequence determined. Sequence comparison confirmed that all of the sequences were chimpanzee hepatitis B virus (chHBV) and they appeared to represent three distinct clusters or branches. To addre...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(01)00334-3
更新日期：2001-11-05 00:00:00
abstract：:One of the essential steps in canine parvovirus (CPV) infection, the release from endosomal vesicles, is dominated by interactions between the virus capsid and the endosomal membranes. In this study, the effect of sphingomyelin and phosphatidyl serine on canine parvovirus capsid and on the phospholipase A(2) (PLA(2)) ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2007.10.008
更新日期：2008-03-01 00:00:00
abstract：:Several potexviruses (Family Alphaflexiviridae) have been reported infecting cassava (Manihot esculenta Crantz) in the Americas. They were isolated from severely diseased plants during the last 30-40 years and include: Cassava common mosaic virus (CsCMV), Cassava Caribbean mosaic virus (CsCaMV), Cassava Colombian symp...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2017.03.019
更新日期：2017-09-15 00:00:00
abstract：:Satellite RNAs (satRNAs) and viroids belong to the group called subviral agents and are the smallest pathogens of plants. In general, small satRNAs and viroids are 300-400 nt in size and do not encode any functional proteins; they are thus regarded as so-called long noncoding RNAs (lncRNAs). These lncRNAs are receivin...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/j.virusres.2015.06.016
更新日期：2016-01-02 00:00:00
abstract：:The adenovirus type 2 protease (EP) was expressed by infecting insect cells with a recombinant baculovirus. Immunoblot and activity analysis showed EP to be present in both the nucleus and cytoplasm. While the insect cell expressed EP was more soluble than the Escherichia coli expressed EP, its activity was one quarte...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(95)00018-l
更新日期：1995-07-01 00:00:00
abstract：:DNA polymerase (DNApol) is highly conserved in baculovirus and is required for viral DNA replication. However, little is known about gammabaculovirus DNApol. Here DNApol of the gammabaculovirus Neodiprion lecontei nucleopolyhedrovirus (NeleNPV) was cloned into a dnapol-null alphabaculovirus AcMNPV bacmid, creating Bac...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2019.04.005
更新日期：2019-06-01 00:00:00
abstract：:Norovirus (NoV) is a major pathogenic agent of human acute viral gastroenteritis that occurs worldwide. In March 2017, a series of acute NoV-associated gastroenteritis outbreaks occurred in Hubei Province in central China. Here, we sought to better understand the main genotypes and potential evolutionary advantages of...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2018.03.016
更新日期：2018-04-02 00:00:00
abstract：:At present there is much interest in the cell tropism and host range of influenza viruses, especially those of the H5N1 subtype. We wished to develop a method that would enable investigation of attachment of infectious virus through the interaction of the hemagglutinin molecule and live mammalian and avian cells and t...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2007.07.007
更新日期：2007-11-01 00:00:00
abstract：:Adaptation of the prototype A/FM/1/47 H1N1 strain to mice resulted in selection of the A/FM/1/47-MA variant with increased virulence. Earlier analysis identified mutations in the HA and M1 genes that increase virulence in the mouse. Complete sequence analysis identified mutations in the PB1, PB2, HA, NA, and M1 genes....
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(99)00027-1
更新日期：1999-05-01 00:00:00
abstract：:The fusion (F) proteins of 10 strains of bovine respiratory syncytial virus (BRSV) were compared by radioimmunoprecipitation with fractionation on SDS-polyacrylamide gels. Two different molecular weights (15 kDa and 20 kDa) of the F2 proteins were demonstrated among the BRSV strains tested. To delineate the molecular ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(93)90059-v
更新日期：1993-08-01 00:00:00
abstract：:This report provides evidence for the replication of varicella zoster virus (VZV) in Raji cells. Infection was achieved by co-cultivation of Raji cells with VZV-infected human fibroblasts. Replication of VZV, as assessed by immunofluorescence using monoclonal antibodies against VZV-glycoproteins, ranged from 18 to 24%...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(86)90080-8
更新日期：1986-06-01 00:00:00
abstract：:To examine the mechanism of HIV-1 regulation by NF-IL6 in activated human cells, we selected a Jurkat cell line that did not contain endogenous NF-IL6. In this cellular environment, we evaluated the effect of exogenous NF-IL6 on transcription mediated by native and deleted LTR sequences. In Jurkat cells stimulated wit...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(02)00110-7
更新日期：2002-10-01 00:00:00
abstract：:The compound LPRP-Et-97543 was isolated from Liriope platyphylla roots and was observed to have potential anti-viral effects in HepG2.2.15 cells against hepatitis B virus (HBV). The antiviral mode was further clarified, and the HBV-transfected Huh7 cells were used as the platform. During viral gene expression, LPRP-Et...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2014.07.015
更新日期：2014-11-04 00:00:00
abstract：:The uptake of porcine parvovirus (PPV) into host cells, permissive or nonpermissive for PPV replication, was monitored by autoradiography, immunofluorescent microscopy, and dual parameter flow cytometry. While both permissive and nonpermissive cells selectively took up the light (activated) form of the virus from a mi...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(88)90054-8
更新日期：1988-04-01 00:00:00
abstract：:Vesicular exanthema of swine virus (VESV), the prototype calicivirus, is the etiologic agent of the porcine disease vesicular exanthema of swine (VES). VES is characterized by vesicle formation on the extremities, mouth and snout and causes abortions and stillbirths if infection occurs during pregnancy. VESV is consid...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(98)00013-6
更新日期：1998-03-01 00:00:00
abstract：:To model HCV resistance to a treatment with interferon-alpha (IFN-alpha) and ribavirin, Huh7 cells, bearing HCV subgenomic replicons, were treated with these compounds for several weeks. Analysis of the cell clones, which were able to support replication of HCV RNA in the presence of high concentrations of these antiv...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2006.12.007
更新日期：2007-04-01 00:00:00
