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Programmed ribosomal frameshifting in HIV-1 and the SARS-CoV.

Abstract：

:Ribosomal frameshifting is a mechanism of gene expression used by several RNA viruses to express replicase enzymes. This article focuses on frameshifting in two human pathogens, the retrovirus human immunodeficiency virus type 1 (HIV-1) and the coronavirus responsible for severe acute respiratory syndrome (SARS). The nature of the frameshift signals of HIV-1 and the SARS-CoV will be described and the impact of this knowledge on models of frameshifting will be considered. The role of frameshifting in the replication cycle of the two pathogens and potential antiviral therapies targeting frameshifting will also be discussed.

journal_name

Virus Res

journal_title

Virus research

authors

Brierley I,Dos Ramos FJ

doi

10.1016/j.virusres.2005.10.008

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

29-42

issue

1

eissn

0168-1702

issn

1872-7492

pii

S0168-1702(05)00321-7

journal_volume

119

pub_type

杂志文章,评审

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