Abstract:
:Damage to the Kupffer and endothelial cells of the liver sinusoids induced by the administration of sublethal doses of frog virus 3 (FV 3) renders A/J mice which are genetically resistant to mouse hepatitis virus type 3 (MHV 3) highly susceptible to this virus. Liver histopathology of these animals revealed typical necrotic foci containing MHV 3-specific antigens. FV 3-pretreated mice, after MHV 3 infection, showed higher levels of serum transaminase (GPT) than controls, and MHV 3 replicated more rapidly and to higher titres. Our results bear out the important role of the liver sinusoidal lining in protecting against hepatocyte infection and its direct involvement in the resistance of A/J mice to MHV 3 infection.
journal_name
Virus Resjournal_title
Virus researchauthors
Pereira CA,Steffan AM,Kirn Adoi
10.1016/0168-1702(84)90013-3subject
Has Abstractpub_date
1984-10-01 00:00:00pages
557-63issue
7eissn
0168-1702issn
1872-7492pii
0168-1702(84)90013-3journal_volume
1pub_type
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