Porcine adenoviruses types 1, 2 and 3 have short and simple early E-3 regions.

Abstract:

:The nucleotide sequence of the E-3 region genes, the hexon associated protein pVIII genes, and part of the fiber genes coding for the N-terminal tail regions, of porcine adenovirus (PAV) types 1 and 2 were determined. The sizes of the E-3 regions were found to be 1162 and 1222 bp, respectively. The five open reading frames (ORF) encoded within the sequenced regions of PAV types 1 and 2 shared a high degree of homology with the published sequences of the corresponding ORFs of PAV-3. The E-3 regions of PAV types 1, 2 and 3 were further characterized by Northern blot analysis and 5' and 3' end mapping of the transcripts by S1 nuclease analysis. The results of these experiments indicated that the E-3 regions in these three viruses are shorter and simpler in organization than the E-3 regions of human adenoviruses. A potential promoter for the E-3 regions of these PAVs was identified.

journal_name

Virus Res

journal_title

Virus research

authors

Reddy PS,Idamakanti N,Derbyshire JB,Nagy E

doi

10.1016/0168-1702(96)01336-6

subject

Has Abstract

pub_date

1996-08-01 00:00:00

pages

99-109

issue

2

eissn

0168-1702

issn

1872-7492

pii

0168170296013366

journal_volume

43

pub_type

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