Abstract：
:Canine distemper virus (CDV) is a major pathogen of dogs and represents a serious threat to both unvaccinated and vaccinated animals. This study surveyed dogs with or without clinical signs related to canine distemper from different regions of Brazil from 2008 to 2012. A total of 155 out of 386 animals were found to be CDV positive by RT-PCR; 37 (23.8%) dogs were asymptomatic at the time of sampling, and 90 (58%) displayed clinical signs suggestive of distemper. Nineteen (12.2%) dogs had a record of complete vaccination, 15 (9.6%) had an incomplete vaccination protocol, and 76 (49%) had no vaccination record. Based on the sequence analysis of the complete hemagglutinin gene of 13 samples, 12 of the strains were characterized as Genotype South America-I/Europe. Considering criteria of at least 95% nucleotide identity to define a genotype and 98% to define a subgenotype, South America-I/Europe sequences segregated into eight different phylogenetically well-defined clusters that circulated or co-circulated in distinct geographical areas. Together, these findings highlight the relevance of CDV infection in Brazilian dogs, demonstrate the predominance of one genotype in Brazil and support the need to intensify the current control measures.
journal_name
Virus Resjournal_title
Virus researchauthors
Budaszewski Rda F,Pinto LD,Weber MN,Caldart ET,Alves CD,Martella V,Ikuta N,Lunge VR,Canal CWdoi
10.1016/j.virusres.2013.12.024subject
Has Abstractpub_date
2014-02-13 00:00:00pages
76-83eissn
0168-1702issn
1872-7492pii
S0168-1702(13)00453-Xjournal_volume
180pub_type
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