Abstract：
BACKGROUND:HTLV-2 infections are almost always asymptomatic, and diseases associated with the infection are rarely reported. Little information is available on the relationship between HTLV-2 proviral load and gender or expression of disease, especially among patients with HIV-1 co-infection. METHODS:We studied 77 HTLV-2-infected subjects followed in our clinic for the last 9 years; 53 (69%) of them were co-infected with HIV-1. HTLV-2 DNA proviral load (PVL) was measured by real time PCR, a test with a sensitivity of 10 in 10(4) PBMCs. RESULTS:Six of 53HTLV-2/HIV-1 cases had a myelopathy (all of them had undetectable PVL of HTLV-2). Only 3 of 35 women (2 out of 3 co-infected with HIV) had a detectable PVL, whereas 10 of 42 men had a detectable PVL. Regardless of their HIV status women had significantly lower PVL than men (10 vs. 43 copies/10(4) PBMCs, p<0.05). CONCLUSIONS:We noticed the occurrence of myelopathy in HTLV-2/HIV-1 co-infected patients, with undetectable HTLV-2 viral load. There was a sex difference in viral load for HTLV-2, what may be the result in mode of transmission or acquisition of the virus.
journal_name
Virus Resjournal_title
Virus researchauthors
Montanheiro P,Olah I,Fukumori LM,Smid J,Oliveira AC,Kanzaki LI,Fonseca LA,Duarte AJ,Casseb Jdoi
10.1016/j.virusres.2008.01.015subject
Has Abstractpub_date
2008-07-01 00:00:00pages
22-5issue
1eissn
0168-1702issn
1872-7492pii
S0168-1702(08)00058-0journal_volume
135pub_type
杂志文章相关文献
VIRUS RESEARCH文献大全abstract：:In Canada, hantavirus infected deer mice (Peromyscus maniculatus) have been collected from British Columbia to Newfoundland. Partial sequencing of G1 and N protein encoding regions from Canadian Peromyscus maniculatus-borne hantaviruses demonstrated the existence of significant genotypic divergence among strains. Phyl...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(01)00227-1
更新日期：2001-05-01 00:00:00
abstract：:Rabies virus has been shown to induce apoptosis in infected cells, but the intracellular pathway of cell killing is unknown. In this report, we show that rabies virus infected mouse neuroblastoma cells underwent chromatin condensation and DNA fragmentation within 48 h post-infection. An increased level of the apoptoti...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(98)00078-1
更新日期：1998-08-01 00:00:00
abstract：:Although a significant progress has been achieved on dsRNA mediated anti-virus strategy development, there is still no effective means to control the virulent white spot syndrome virus (WSSV). Six double-stranded RNAs specific to different essential genes of WSSV (ie1, ie3, pol (DNA polymerase), rr2 (ribonucleotide re...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2009.06.018
更新日期：2009-10-01 00:00:00
abstract：:We have recently identified and sequenced a molecular clone of the serogroup 2 simian retrovirus (SRV), D2/RHE/OR/V1, that retains an enhanced ability to infect specific T cell lines. In this report, using deletion mutagenesis, we localized the psi packaging signal, necessary for packaging of D2/RHE/OR/V1 particles, t...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(01)00236-2
更新日期：2001-06-01 00:00:00
abstract：:Herein we describe the construction of recombinant human rhinoviruses (rHRVs) encoding HIV Gag or Tat by inserting the full length tat gene or regions of the gag gene flanked by sequences encoding the HRV 2A protease cleavage site into the junction between HRV genes encoding structural (P1) and non-structural (P2) pro...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2015.04.002
更新日期：2015-05-04 00:00:00
abstract：:The intercellular adhesion molecule-1 (ICAM-1) receptor was expressed in primary chicken embryo cells using a retroviral vector and shown to specifically bind major group human rhinoviruses (HRVs). A truncated, membrane-bound ICAM-1 protein containing N-terminal domains 1, 2, and 3 retained the ability to bind virus w...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(92)90005-t
更新日期：1992-07-01 00:00:00
abstract：:Since February 2013, H7N9 influenza virus, causing human infections with high mortality in China, has been a potential pandemic threat. The H7N9 viruses are found to diverge into distinct genotypes as other influenza viruses; thus a vaccine that can provide sufficient cross-protection against different genotypes of H7...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2017.09.008
更新日期：2017-10-15 00:00:00
abstract：:The 2015 Brazilian Zika virus outbreak sparked a rapid response to control the spread of the virus. What was first understood to be a mild self-resolving infection is now linked to significant neurological defects in both neonates and adults. The WHO declared the 2016 Zika epidemic a public health emergency and issued...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/j.virusres.2017.07.025
更新日期：2018-08-02 00:00:00
abstract：:Virus entry into host cells relies on interactions between viral and host structures including lipids, carbohydrates and proteins. Particularly, protein-protein interactions between viral surface proteins and host proteins as well as secondary host protein-protein interactions play a pivotal role in coordinating virus...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/j.virusres.2015.09.006
更新日期：2016-06-15 00:00:00
abstract：:Fruit trees of temperate and tropical climates are of great economical importance worldwide and several viruses have been reported affecting their productivity and longevity. Fruit trees of different Brazilian regions displaying virus-like symptoms were evaluated for infection by circular DNA viruses. Seventy-four fru...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2015.07.005
更新日期：2015-12-02 00:00:00
abstract：:The capsid structures of the 7 serotypes of foot-and-mouth disease virus have been compared utilizing a series of neutralizing monoclonal antibodies which were previously shown to recognize at least 4 distinct epitopes on type A12 virus. A radioimmune binding assay using radioactively labeled antigens and the monoclon...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(86)90055-9
更新日期：1986-10-01 00:00:00
abstract：:Bovine herpesvirus-1 (BoHV-1) causes disease in cattle with varied clinical forms. In the U.S. there are two BoHV1 subtypes, BoHV-1.1 and BoHV-1.2b. Control programs in North America incorporate modified live (MLV) or killed (KV) viral vaccines. However, BoHV-1 strains continue to be isolated from diseased animals or ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2016.06.017
更新日期：2016-09-02 00:00:00
abstract：:Ranaviruses (family Iridoviridae, genus Ranavirus) have been recognized as emerging infectious pathogens and caused a great loss to the global biodiversity. Thymidine kinase (TK) and deoxyuridine triphosphatase (dUTPase, DUT, encoded by ORF 67R) are ubiquitous, existing in iridoviruses and other organisms. Previous st...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2016.01.008
更新日期：2016-03-02 00:00:00
abstract：:Apoptosis is an important mechanism of human immunodeficiency virus type 1 (HIV-1)-induced T-cell depletion. Our recent findings revealed mitogenic stimulation-dependent apoptosis induction in healthy donor-derived peripheral blood T-lymphocytes after adsorption with defective HIV-1 particles through acquirement by a ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(98)00052-5
更新日期：1998-07-01 00:00:00
abstract：:The T-helper response to the measles virus nucleoprotein (NP) has been studied in mice. The T-cell proliferative response was measured in lymphocytes from mice immunized with either a vaccinia measles-NP recombinant virus or a mouse neuro-adapted measles virus. A T-cell response was obtained with lymphocytes from H2d ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(92)90088-q
更新日期：1992-01-01 00:00:00
abstract：:To study the process of feline immunodeficiency virus (FIV) assembly, we examined the suitability of the vaccinia vector system to reproduce FIV particle formation. To this end, we constructed a recombinant vaccinia virus carrying the FIV gag gene. Biochemical and electron microscopy analyses of cells infected with th...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(01)00249-0
更新日期：2001-07-01 00:00:00
abstract：:Coronaviruses are a large group of enveloped, single-stranded positive-sense RNA viruses that infect a wide range of avian and mammalian species, including humans. The emergence of deadly human coronaviruses, severe acute respiratory syndrome coronavirus (SARS-CoV), and Middle East respiratory syndrome coronavirus (ME...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/j.virusres.2014.11.021
更新日期：2015-04-16 00:00:00
abstract：:To investigate the evolutionary origins of proteins encoded by the Poxviridae family of viruses, we examined all poxvirus protein coding genes using a method of characterizing and visualizing the similarity between these proteins and taxonomic subsets of proteins in GenBank. Our analysis divides poxvirus proteins into...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2009.05.006
更新日期：2009-09-01 00:00:00
abstract：:Citrus psorosis (CPsV) and Mirafiori lettuce big-vein virus (MiLBVV) belong to the family Ophioviridae, plant viruses with filamentous nucleocapsids and segmented genomes of negative polarity, causing the worldwide distributed citrus psorosis and lettuce big-vein diseases, respectively. To gain insight into the replic...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2012.08.005
更新日期：2012-12-01 00:00:00
abstract：:Analysis of complete polyprotein-encoding sequences of the two most prevalent genotypes of hepatitis C virus (HCV-1a and HCV-1b) revealed evidence of abundant, slightly deleterious nonsynonymous variants subject to ongoing purifying selection. In the case of both HCV-1a and HCV-1b, the NS3 protein demonstrated a high ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2009.11.001
更新日期：2010-02-01 00:00:00
abstract：:Variants assigned to GI-23 lineage of infectious bronchitis virus (IBV), formerly called Var2, have circulated for nearly 20 years only in countries of the Middle East. Strains of this lineage were first identified in Israel in 1998. More severe form of the virus appeared in 2006, when the second wave of Var2 epidemic...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2017.09.010
更新日期：2017-10-15 00:00:00
abstract：:Dengue virus (DENV) infection associates with renal disorders. Patients with dengue hemorrhagic fever and acute kidney injury have a high mortality rate. Increased levels of cytokines may contribute to the pathogenesis of DENV-induced kidney injury. Currently, molecular mechanisms how DENV induces kidney cell injury h...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2014.12.007
更新日期：2015-02-02 00:00:00
abstract：:White spot syndrome virus immediate early (IE) gene wsv249 encodes an E3 ubiquitin ligase that can interact with a shrimp ubiquitin-conjugating enzyme to mediate ubiquitination. In this study, to understand the transcriptional regulation of wsv249, a serial of 5'-truncated mutations were made on its promoter and the a...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2018.05.012
更新日期：2018-07-02 00:00:00
abstract：:Bovine viral diarrhea virus (BVDV) infection in cattle can lead to the development of a fatal syndrome called mucosal disease (MD). The induction of MD requires co-existence of two biotypes of BVDV: cytopathic (cp) and non-cytopathic (ncp). Studies have shown that in some cases, cp viruses are generated from ncp virus...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(98)00073-2
更新日期：1998-09-01 00:00:00
abstract：:The attenuated equine infectious anemia virus (EIAV) vaccine was the first attenuated lentivirus vaccine to be used in a large-scale application and has been used to successfully control the spread of equine infectious anemia (EIA) in China. To better understand the potential role of cytokines in the pathogenesis of E...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2011.06.028
更新日期：2011-09-01 00:00:00
abstract：:The mechanism by which hepatitis B virus (HBV) infection causes severe inflammatory liver diseases is multifactorial and related to interactions with cell signaling pathways and the ensuing inflammatory response. Activation of JAK/STAT/SOCS signaling is essential for the induction of cellular antiviral responses, cont...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2009.12.003
更新日期：2010-03-01 00:00:00
abstract：:Bovine herpesvirus-1 infected cell protein 27 (BICP27) was detected predominantly in the nucleolus. The open reading frame of BICP27 was fused with the enhanced yellow fluorescent protein (EYFP) gene to investigate its subcellular localization in live cells and BICP27 was able to direct monomeric, dimeric or trimeric ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2009.07.024
更新日期：2009-11-01 00:00:00
abstract：:Adult T cell leukemia/lymphoma (ATL) is a highly aggressive CD4+/CD25+ T-cell malignancy caused by human T cell lymphotropic virus type 1 (HTLV-1). Previous studies in the MET-1 cell/NOD/SCID mouse model of ATL demonstrated that MET-1 cells are very susceptible to measles virus (MV) oncolytic therapy. To further evalu...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2014.05.025
更新日期：2014-08-30 00:00:00
abstract：:The evolution of virus diseases, both their emergence and disappearance, involves complex interactions between the agent, the host, and the environment. These themes are illustrated by three examples, poliomyelitis of humans, bovine spongiform encephalopathy of cattle, and AIDS of humans. Emergence may be due to evolu...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/0168-1702(93)90122-4
更新日期：1993-07-01 00:00:00
abstract：:In the early 1970s, the Chinese Equine Infectious Anemia Virus (EIAV) vaccine, EIAV(DLA), was developed through successive passages of a wild-type virulent virus (EIAV(L)) in donkeys in vivo and then in donkey macrophages in vitro. EIAV attenuation and cell tropism adaptation are associated with changes in both envelo...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2007.04.005
更新日期：2007-09-01 00:00:00
