Abstract:
:To investigate the evolutionary origins of proteins encoded by the Poxviridae family of viruses, we examined all poxvirus protein coding genes using a method of characterizing and visualizing the similarity between these proteins and taxonomic subsets of proteins in GenBank. Our analysis divides poxvirus proteins into categories based on their relative degree of similarity to two different taxonomic subsets of proteins such as all eukaryote vs. all virus (except poxvirus) proteins. As an example, this allows us to identify, based on high similarity to only eukaryote proteins, poxvirus proteins that may have been obtained by horizontal transfer from their hosts. Although this method alone does not definitively prove horizontal gene transfer, it allows us to provide an assessment of the possibility of horizontal gene transfer for every poxvirus protein. Potential candidates can then be individually studied in more detail during subsequent investigation. Results of our analysis demonstrate that in general, proteins encoded by members of the subfamily Chordopoxvirinae exhibit greater similarity to eukaryote proteins than to proteins of other virus families. In addition, our results reiterate the important role played by host gene capture in poxvirus evolution; highlight the functions of many genes poxviruses share with their hosts; and illustrate which host-like genes are present uniquely in poxviruses and which are also present in other virus families.
journal_name
Virus Resjournal_title
Virus researchauthors
Odom MR,Hendrickson RC,Lefkowitz EJdoi
10.1016/j.virusres.2009.05.006subject
Has Abstractpub_date
2009-09-01 00:00:00pages
233-49issue
1-2eissn
0168-1702issn
1872-7492pii
S0168-1702(09)00200-7journal_volume
144pub_type
杂志文章相关文献
VIRUS RESEARCH文献大全abstract::Since 2002 there has been a rise in arthrogryposis/hydranencephaly (AGH) incidence in Israel, caused by Akabane (AKA) and, possibly, Aino viruses. To test the ability to control the disease, three siRNA genes targeted to the S genome segment were designed and prepared in the form of siRNA cassettes. For the design all...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2006.02.009
更新日期:2006-09-01 00:00:00
abstract::The protein and glycoprotein composition of a sucrose gradient fraction from vaccinia infected cells treated with rifampicin was studied. This particulate fraction contained cytoplasmic membranes and pleomorphic membranous structures. The glycoproteins (89, 42 and 20-23 kDa, respectively) were identified as the same g...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/0168-1702(90)90077-o
更新日期:1990-08-01 00:00:00
abstract::A sero-epidemiologic survey of 74 IVDUs and 86 age-matched controls was performed to investigate the prevalence, clinical significance, and genetic distribution of GB virus C (GBV-C)/hepatitis G virus (HGV) infection among intravenous drug users (IVDUs) in Japan. GBV-C/HGV RNA was detected by reverse transcriptase-hem...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/s0168-1702(97)01470-6
更新日期:1997-06-01 00:00:00
abstract::Eighteen monoclonal antibodies were produced against three Australian bovine enterovirus serogroups. Based on their binding patterns to 14S subunits, natural empty capsids and virions of 4 selected viral isolates (K2577, SL305, 66/27, J2129) in two types of quantitative ELISAs, the 18 antibodies were shown to belong t...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/0168-1702(90)90050-l
更新日期:1990-07-01 00:00:00
abstract::Marek's disease virus (MDV) is an oncogenic herpesvirus that causes a disease in chickens characterized by tumor formation and immunosuppression. In this paper, we identified differentially expressed proteins in the bursa of Fabricius of chickens infected with the highly virulent MDV strain RB1B, using two-dimensional...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2010.08.010
更新日期:2010-11-01 00:00:00
abstract::As master transcription factors for lipogenesis, sterol regulatory element-binding protein-1 (SREBP-1) has two isoforms, SREBP-1a and SREBP-1c. Hepatitis B virus X (HBx) can up-regulate the transcription of both SREBP-1a and SREBP-1c. HBx is a small protein consisting of 154 amino acids. Truncated forms of HBx, often ...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2015.07.011
更新日期:2015-12-02 00:00:00
abstract::Stress granules (SGs) are structures within cells that regulate gene expression during stress response, e.g. viral infection. In mammalian cells assembly of SGs is dependent on the Ras-GAP SH3-domain-binding protein (G3BP). The C-terminal domain of the viral nonstructural protein 3 (nsP3) of Semliki Forest virus (SFV)...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2016.09.021
更新日期:2017-01-02 00:00:00
abstract::Utilizing the reverse transcriptase-polymerase chain reaction (RT-PCR) procedure, we have synthesized full-length copies of segment 10 from African horsesickness virus (AHSV) serotypes 1, 4 and 8. The genes were cloned, sequenced and compared with the sequence of the cognate gene from AHSV serotypes 3 and 9. Sequences...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/0168-1702(94)90052-3
更新日期:1994-08-01 00:00:00
abstract::Influenza virus rgVac1sub-P0 (H5N1) (rgVac1-P0), in which a pair of dibasic amino acid residues was introduced at the cleavage site of the HA of a reassortant of H5N2 and H7N1 viruses of duck origin, was low pathogenic in chickens. Vac1sub-P3 (H5N1) (Vac1-P3) was selected as a highly pathogenic avian influenza virus b...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2013.02.001
更新日期:2013-05-01 00:00:00
abstract::The role of the C2 protein in the pathogenicity of tomato yellow leaf curl Sardinia virus (TYLCSV) was investigated. Here we report that Agrobacterium-mediated transient expression of TYLCSV C2 resulted in a strong hypersensitive response (HR) in Nicotiana benthamiana, N. tabacum, and Arabidopsis thaliana, with induct...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2016.01.014
更新日期:2016-04-02 00:00:00
abstract::The pathogenesis of chorioallantoic membrane (CAM) infection with herpes simplex virus 1 and 2 (HSV-1 and HSV-2) as well as chick embryo fibroblast (CEF) passaged HSV-1 was studied. It was found that HSV-2 is at least a million-fold more virulent than HSV-1 as measured by pfu/LD50 ratios for the embryo. Serial passage...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/0168-1702(86)90017-1
更新日期:1986-08-01 00:00:00
abstract::Non-structural protein1β (Nsp1β) of porcine reproductive and respiratory syndrome virus (PRRSV) has been recognized to be involved in suppressing the host innate immune response and mediating viral subgenomic mRNA transcription. In the present study, we have analyzed the interaction of Nsp1β of Chinese highly pathogen...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2012.08.002
更新日期:2012-10-01 00:00:00
abstract::The nature of the interaction between papillomaviruses (PV) and their infected host has led to the identification of ways in which the viral oncoproteins can transform the infected host cells into cancer cells. As viral persistence is required for malignancy, and persistence requires avoidance of immune attack by the ...
journal_title:Virus research
pub_type: 杂志文章,评审
doi:10.1016/s0168-1702(02)00123-5
更新日期:2002-09-01 00:00:00
abstract::A fragment of DNA from within the minimum transforming region (mtr-1) of herpes simplex virus type 1 (HSV-1) is known to raise the mutation frequency of cells. This activity has been attributed to a viral protein whose properties are largely unknown. Antiserum was raised to a synthetic peptide of a predicted amino aci...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/0168-1702(94)90093-0
更新日期:1994-11-01 00:00:00
abstract::Here we document that the gene VI product of peanut chlorotic streak virus (PClSV), a newly characterized member of the group, transactivates the translation of dicistronic transcripts. Dicistronic expression units have been analyzed both in protoplast transient expression experiments and in transgenic tobacco plants....
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/s0168-1702(98)00088-4
更新日期:1998-10-01 00:00:00
abstract::All entero- and rhinovirus RNAs sequenced thus far possess A and U residues at positions corresponding to nucleotides 480 and 525, respectively, of poliovirus type 1. These two nucleotides have been proposed previously to form a base pair. The single exception to this rule appears to be the Sabin type 1 strain, which ...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/0168-1702(91)90002-d
更新日期:1991-10-01 00:00:00
abstract::The human T-lymphotropic virus type-1 (HTLV-1) is the causative agent of a chronic progressive myelopathy (TSP/HAM) in which lesions of the central nervous system (CNS) are associated with infiltration of HTLV-1-infected T-cells. In a model that mimics the interaction between glial and T-cells, we show that transient ...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/s0168-1702(01)00284-2
更新日期:2001-10-30 00:00:00
abstract::Previous investigations suggest that the divergence of the group I alphabaculoviruses was later than that of the group II alphabaculoviruses, however, there is no quantitative data to support this hypothesis. To examine this theory, the evolutionary rates of the 30 core genes that are conserved among all baculoviruses...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2009.01.015
更新日期:2009-06-01 00:00:00
abstract::The structural envelope glycoprotein GP4 of European porcine reproductive and respiratory syndrome virus (PRRSV) strains contains a highly variable neutralizing epitope that is susceptible to neutralizing antibody-mediated selective pressure in vitro. In this study, it was analyzed what happens with this neutralizing ...
journal_title:Virus research
pub_type: 杂志文章,评审
doi:10.1016/j.virusres.2010.08.026
更新日期:2010-12-01 00:00:00
abstract::Mammalian orthoreovirus (MRV) is the type species of the genus Orthoreovirus and causes a range of significant respiratory, nervous or enteric diseases in humans and animals. In 2016 a farmed white-tailed deer (Odocoileus virginianus) fawn became ill, displaying clinical signs of lethargy, dehydration, and profuse fou...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2019.197642
更新日期:2019-09-01 00:00:00
abstract::Bats are reservoir hosts of many zoonotic viruses and identification of viruses that they carry is important. This study aimed to use high throughput screening to identify the viruses in fecal guano of Taiwanese insectivorous bats caves in order to obtain more information on bat-derived pathogenic viruses in East Asia...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2018.10.020
更新日期:2019-01-02 00:00:00
abstract::Mixed viral infections can induce different changes in symptom development, genome accumulation and tissue tropism. These issues were investigated for two phloem-limited begomoviruses, Abutilon mosaic virus (AbMV) and Tomato yellow leaf curl Sardinia virus (TYLCSV) in Nicotiana benthamiana plants doubly infected by ei...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2011.07.021
更新日期:2011-11-01 00:00:00
abstract::Tick-borne encephalitis (TBE) is a serious human neurological disease caused by TBE virus (TBEV). However, the mechanisms of TBEV-caused pathogenesis remain unclear. The endoplasmic reticulum (ER) stress response, also defined as the unfolded protein response (UPR), is an important conserved molecular signaling pathwa...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2013.10.012
更新日期:2013-12-26 00:00:00
abstract::Herein we describe the construction of recombinant human rhinoviruses (rHRVs) encoding HIV Gag or Tat by inserting the full length tat gene or regions of the gag gene flanked by sequences encoding the HRV 2A protease cleavage site into the junction between HRV genes encoding structural (P1) and non-structural (P2) pro...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2015.04.002
更新日期:2015-05-04 00:00:00
abstract::Prion diseases are fatal neurodegenerative disorders by which the native cellular prion protein (PrPC) is misfolded into an accumulating, disease-associated isoform (PrPD). To improve the understanding of prion pathogenesis and develop effective treatments, it is essential to elucidate factors contributing to cellular...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2017.07.016
更新日期:2017-08-15 00:00:00
abstract::The entire genome of a mid-Atlantic raccoon strain rabies virus (RRV) isolated in Canada was sequenced; this is the second North American wildlife rabies virus isolate to be fully characterized. The overall organization and length of the genome was similar to that of other lyssaviruses. The nucleotide sequence identit...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2008.04.029
更新日期:2008-09-01 00:00:00
abstract::We here report the results of an investigation of the effect of interferon on the establishment of new infections by a retrovirus. For this study, we used an infectious but replication-incompetent retrovirus carrying a drug-resistance gene and assayed for infectivity by measuring drug-resistant colony formation. Mouse...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/0168-1702(89)90075-0
更新日期:1989-08-01 00:00:00
abstract::RNA-2 P75 open reading frame sequencing was conducted on BNYVV-infected sugar beet plants originating from 10 Belgian sources and was compared with sequences originating from France, Kazakhstan, Japan and China. This allowed the characterization of types A and B in Belgium. Sequence analysis confirmed that type A is i...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2004.07.007
更新日期:2005-03-01 00:00:00
abstract::Cell lines were constructed which permanently express influenza virus-specific RNA. Two approaches were followed. C127 cells were transformed with bovine papilloma virus (BPV) vectors and the resulting cell lines were found to inhibit the replication of influenza virus at low multiplicity of infection (MOI 0.05). Howe...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/0168-1702(89)90035-x
更新日期:1989-10-01 00:00:00
abstract::In recent years, the spread of Duck Hepatitis A Viruses (DHAVs) has represented a serious threat and significant economic impact in duck industry of China. The sixteen reported DHAV isolates (15 DHAV-1 strains and one DHAV-3) were identified from infected ducks with clinical symptoms in China between 2009 and 2012. In...
journal_title:Virus research
pub_type: 杂志文章
doi:10.1016/j.virusres.2013.10.007
更新日期:2013-12-26 00:00:00