Abstract：
:The human T-lymphotropic virus type-1 (HTLV-1) is the causative agent of a chronic progressive myelopathy (TSP/HAM) in which lesions of the central nervous system (CNS) are associated with infiltration of HTLV-1-infected T-cells. In a model that mimics the interaction between glial and T-cells, we show that transient contact with T-lymphocytes chronically infected with HTLV-1 induce profound metabolic alterations in astrocytes. Within the first week post-contact, an overall activation of astrocyte metabolism was observed as assessed by enhanced uptake of glutamate and glucose, and lactate release. In contrast, longer examination showed a reduced astrocytic accumulation of glutamate. The time course of the change in glutamate uptake was in fact biphasic. Previous observations indicated that HTLV-1 protein Tax-1 was involved in this delayed decrease, via the induction of TNF-alpha. The expression of the glial glutamate transporters, GLAST and GLT-1 decreased in parallel. These decreases in glutamate uptake and transporters' expression were associated with an imbalance in the expression of the catabolic enzymes of glutamate, GS and GDH, presumably due to Tax-1. Given the fact that impairment of glutamate management in astrocytes is able to compromise the functional integrity of neurons and oligodendrocytes, our results altogether give new insights into the physiopathology of TSP/HAM.
journal_name
Virus Resjournal_title
Virus researchauthors
Akaoka H,Szymocha R,Beurton-Marduel P,Bernard A,Belin MF,Giraudon Pdoi
10.1016/s0168-1702(01)00284-2subject
Has Abstractpub_date
2001-10-30 00:00:00pages
57-66issue
1-2eissn
0168-1702issn
1872-7492pii
S0168170201002842journal_volume
78pub_type
杂志文章相关文献
VIRUS RESEARCH文献大全abstract：:Despite the fact that cells infected with wild type vaccinia virus synthesize viral DNA and assemble progeny virus particles within the cytoplasm, the host cell nucleus is required for a productive infection. Recent evidence suggests that vaccinia virus selectively recruits components from the host cell nucleus into t...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/0168-1702(87)90014-1
更新日期：1987-09-01 00:00:00
abstract：:Equine rhinitis A virus (ERAV) is a picornavirus which causes an acute respiratory infection in horses worldwide, and virus neutralization (VN) has been the standard method for the detection of ERAV antibody in horse serum. Previous studies have identified recombinant virion protein VP1 (rVP1) purified under native co...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2009.03.003
更新日期：2009-07-01 00:00:00
abstract：:Porcine reproductive and respiratory syndrome virus (PRRSV), an arterivirus, belongs to a group of RNA viruses that are cytopathic for macrophages and establish persistent infections. Apoptosis is the presumed mechanism of cell death in monkey kidney cell lines and porcine alveolar macrophages after infection with Eur...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(02)00029-1
更新日期：2002-05-10 00:00:00
abstract：:Partial nucleotide sequences of the haemagglutinin (H) gene of 18 measles viruses isolated in the Gambia during 1994 and 1995 show a high degree of homology (> 98.5%) when compared with each other. These sequences form a cluster distinct from measles viruses isolated from other geographic regions and from the sequence...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(96)01434-7
更新日期：1997-05-01 00:00:00
abstract：:The rabies viruses that circulate in Arctic countries and in much of northern and central Asia are phylogenetically closely related and collectively referred to as the Arctic/Arctic-like (AL) lineage. The emergence and spread of this lineage is of significant interest given that rabies remains a serious zoonotic disea...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2011.10.026
更新日期：2012-01-01 00:00:00
abstract：:Previous investigations suggest that the divergence of the group I alphabaculoviruses was later than that of the group II alphabaculoviruses, however, there is no quantitative data to support this hypothesis. To examine this theory, the evolutionary rates of the 30 core genes that are conserved among all baculoviruses...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2009.01.015
更新日期：2009-06-01 00:00:00
abstract：:HCV is an ideal model to study how the infected cell is altered to allow the establishment of a chronic infection. After infection, the transcriptome of the cell changes in response to the virus or to the antiviral pathways induced by infection. The cell has evolved to sense HCV soon after infection and to activate an...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/j.virusres.2015.10.001
更新日期：2016-01-02 00:00:00
abstract：:Hepatitis delta virus (HDV) requires the surface antigens of hepatitis B virus (HBV) for packaging and transmission, but replicates its RNA in an HBV-independent fashion. HDV contains a 1.7-kb circular RNA genome that is folded into an unbranched rod-like structure via intramolecular base-pairing, and possesses ribozy...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/j.virusres.2007.01.003
更新日期：2007-08-01 00:00:00
abstract：:Apoptosis is frequently induced to inhibit virus replication during infection of Enterovirus 71 (EV71). On the contrary, anti-apoptotic pathway, such as PI3K/Akt pathway, is simultaneously exploited by EV71 to accomplish the viral life cycle. The relationship by which EV71-induced apoptosis and PI3K/Akt signaling path...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2014.07.026
更新日期：2014-11-04 00:00:00
abstract：:A temperature-sensitive mutant of the Moloney murine leukemia virus-TB, ts1, causes hindlimb paralysis and immunodeficiency in mice. At the restrictive temperature, the envelope precursor polyprotein, gPr80env, is inefficiently processed intracellularly, and this is associated with the neurovirulence of ts1. To test t...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(91)90096-e
更新日期：1991-03-01 00:00:00
abstract：:Rhabdoviruses cause devastating diseases in aquaculture, resulting in enormous economic losses. Our previous studies indicated that imidazole arctigenin derivatives possessed antiviral activities against aquatic rhabdoviruses. Based on the data of structure-activity relationship, a new imidazole arctigenin derivative,...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2020.198019
更新日期：2020-08-01 00:00:00
abstract：:Human recombinant alpha interferon, A/D, significantly reduced the replication and cell fusion induced by herpes simplex virus type 1 in monkey cells. Thin-section electron microscopy of interferon-treated monkey cells showed distinct assembly of nucleocapsids within the nucleus. Analysis of virus-specific proteins by...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(89)90051-8
更新日期：1989-01-01 00:00:00
abstract：:Real-time and visual tracking of viral infection is crucial for elucidating the infectious and pathogenesis mechanisms. To track the virus successfully, an efficient labeling method is necessary. In this review, we first discuss the practical labeling techniques for virus tracking in live cells. We then describe the c...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/j.virusres.2017.05.007
更新日期：2017-06-02 00:00:00
abstract：:We here report the results of an investigation of the effect of interferon on the establishment of new infections by a retrovirus. For this study, we used an infectious but replication-incompetent retrovirus carrying a drug-resistance gene and assayed for infectivity by measuring drug-resistant colony formation. Mouse...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(89)90075-0
更新日期：1989-08-01 00:00:00
abstract：:The immune response to a naked plasmid DNA encoding the nucleoprotein (N protein) of porcine transmissible gastroenteritis virus (TGEV) was investigated in this study. A complementary DNA of the entire N gene was amplified by RT-PCR, and inserted into a mammalian expression vector (pcDNA3.1) to construct a recombinant...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(01)00333-1
更新日期：2001-11-28 00:00:00
abstract：:We have used vesicular stomatitis virus (VSV) to determine the cost of antiserum resistance during escape from a polyclonal immune response. Replication of VSV in the presence of polyclonal antiserum resulted in the selection of antibody-escape mutants, as shown by increased fitness in the presence of antiserum and by...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2004.06.007
更新日期：2005-01-01 00:00:00
abstract：:The entry of herpes simplex virus (HSV) into an oral epithelial cell line, primary normal human oral keratinocytes (NHOK) and gingival fibroblasts (GF) was examined. Infection of these cells by HSV-1 and HSV-2 was blocked by heparin. Further examination indicated that heparin reduced viral attachment but not penetrati...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(02)00055-2
更新日期：2002-06-01 00:00:00
abstract：:A previously unknown iflavirus has been identified in a laboratory colony of the brown planthopper, Nilaparvata lugens. The iflavirus-like sequence was first identified in contig sequences obtained from transcriptome sequencing (RNA-seq) of the brown planthopper. The complete viral genome was resequenced using the San...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2013.06.005
更新日期：2013-09-01 00:00:00
abstract：:Analysis of complete polyprotein-encoding sequences of the two most prevalent genotypes of hepatitis C virus (HCV-1a and HCV-1b) revealed evidence of abundant, slightly deleterious nonsynonymous variants subject to ongoing purifying selection. In the case of both HCV-1a and HCV-1b, the NS3 protein demonstrated a high ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2009.11.001
更新日期：2010-02-01 00:00:00
abstract：:Species members of the genus Parapoxvirus (PPV) within the family Poxviridae cause contagious pustular dermatitis in small ruminants (Orf virus, ORFV) and mostly mild localized inflammation in cattle (bovine papular stomatitis virus, BPSV and pseudocowpox virus, PCPV). All PPVs are known to be zoonotic, leading to cir...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2013.12.015
更新日期：2014-03-06 00:00:00
abstract：:Bovine viral diarrhea virus (BVDV) infection in cattle can lead to the development of a fatal syndrome called mucosal disease (MD). The induction of MD requires co-existence of two biotypes of BVDV: cytopathic (cp) and non-cytopathic (ncp). Studies have shown that in some cases, cp viruses are generated from ncp virus...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(98)00073-2
更新日期：1998-09-01 00:00:00
abstract：:Infectious salmon anaemia virus (ISAV) is an orthomyxovirus causing anaemia and circulatory disease with high mortality in farmed Atlantic salmon (Salmo salar). Orthomyxoviruses are unusual as RNA viruses as they replicate in the nucleus and some viral transcripts undergo splicing. The nuclear replication necessitates...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2013.07.001
更新日期：2013-10-01 00:00:00
abstract：:Transcription of human immunodeficiency virus (HIV-1) is activated by viral Tat protein which regulates HIV-long terminal repeat (LTR) transcription and elongation. HIV-1 Tat protein is a substrate for the deacetylase activity of sirtuin 1 (SIRT1). Here we investigate the signaling pathway involved in Tat-induced HIV-...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2009.08.005
更新日期：2009-12-01 00:00:00
abstract：OBJECTIVE:This paper aims to explore the effect of four virus inactivation methods on the rapid detection results of COVID-19 nucleic acid. METHODS:Collected samples of nasopharyngeal swabs from 2 patients diagnosed with COVID-19 at the First People's Hospital of Zhaoqing City, each of sample was divided into 5 groups...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2020.197988
更新日期：2020-08-01 00:00:00
abstract：:In the early 1970s, the Chinese Equine Infectious Anemia Virus (EIAV) vaccine, EIAV(DLA), was developed through successive passages of a wild-type virulent virus (EIAV(L)) in donkeys in vivo and then in donkey macrophages in vitro. EIAV attenuation and cell tropism adaptation are associated with changes in both envelo...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2007.04.005
更新日期：2007-09-01 00:00:00
abstract：:The evolution of virus diseases, both their emergence and disappearance, involves complex interactions between the agent, the host, and the environment. These themes are illustrated by three examples, poliomyelitis of humans, bovine spongiform encephalopathy of cattle, and AIDS of humans. Emergence may be due to evolu...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/0168-1702(93)90122-4
更新日期：1993-07-01 00:00:00
abstract：:Mouse hepatitis virus (MHV) nucleocapsid (N) protein binds to the large, single-stranded, positive-sense viral genomic RNA to form a helical nucleocapsid structure in mature virions. In addition N protein binds the intracellular form of the genomic RNA, all of the MHV subgenomic mRNAs, and expressed non-MHV RNA transc...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2003.08.021
更新日期：2003-12-01 00:00:00
abstract：:Recently, a novel deoxyribonucleic acid (DNA) virus, designated SEN virus (SENV), was discovered and strong associations between the two SENV variants (SENV-D and SENV-H) and non-A to E hepatitis were reported. To clarify the character of SENV infection in children, we investigated the detection rates of serum SENV DN...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2003.12.028
更新日期：2004-03-15 00:00:00
abstract：:Hepatitis A virus (HAV) is an important human pathogen causing hepatitis, with high incidence in developed as well as in developing countries. No vaccines are available. In order to determine the primary structure of the HAV genome, we have prepared cDNAs from viral RNA and cloned these into plasmid pBR322. These clon...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(87)90026-8
更新日期：1987-08-01 00:00:00
abstract：:For detection of spring viremia of carp virus (SVCV) DNA probes have been constructed using the reverse transcription-polymerase chain reaction (RT-PCR) amplification technique and cDNA cloning in plasmid and phage vectors. The specific primers for amplification of SVCV M and G genes were chosen and synthesized. Studi...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(99)00052-0
更新日期：1999-09-01 00:00:00
