Abstract：
:Previous investigations suggest that the divergence of the group I alphabaculoviruses was later than that of the group II alphabaculoviruses, however, there is no quantitative data to support this hypothesis. To examine this theory, the evolutionary rates of the 30 core genes that are conserved among all baculoviruses and the 11 unique genes among group I alphabaculoviruses were estimated in this report. For core genes, the synonymous and nonsynonymous substitution rates (Ks and Ka) were found to be significantly different among different groups, with the rates being granulovirus>group II>group I. Among the 11 unique genes, gp64 was found to have the highest amino acid identity and the lowest omega (Ka/Ks) and Ka values. The significant difference in the selection pressure was found in the F-like protein. These analyses suggests the following interpretation: (i) group I evolved from an ancestral group II alphabaculovirus that had 11 genes not present in other members of this group; (ii) the acquisition of the gp64 gene may have stimulated or initiated the formation of the group I as a major lineage distinct from group II; and (iii) after being functionally displaced by gp64, the F-like gene of group I evolved under a relaxed selection pressure that lead to the partial lost of its function.
journal_name
Virus Resjournal_title
Virus researchauthors
Jiang Y,Deng F,Rayner S,Wang H,Hu Zdoi
10.1016/j.virusres.2009.01.015subject
Has Abstractpub_date
2009-06-01 00:00:00pages
85-91issue
1-2eissn
0168-1702issn
1872-7492pii
S0168-1702(09)00021-5journal_volume
142pub_type
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