Abstract：
:MicroRNAs (miRNAs) constitute an important class of non-coding RNA implicated in gene expression regulation. More than 1900 miRNA molecules have been identified in humans and their modulation during viral infection and it is recognized to play a role in latency regulation or in establishing an antiviral state. The liver cells are targets during DENV infection, and alteration of liver functions contributes to severe disease. In this work the miRNAs expression profile of the human hepatoma cell line, Huh-7, infected with DENV-2 was determined using microarray and real-time PCR. Let-7c is one of the miRNAs up-regulated during DENV infection in the hepatic Huh-7 as well as in the macrophage-monocytic cell line U937-DC-SIGN. Let-7c overexpression down-regulates both DENV-2 and DENV-4 infection. Additionally, we found that the transcription factor BACH1, a let-7c target, is also down-regulated during DENV infection. In accordance with this finding, HO-1, the main responsive factor of BACH1 was found up-regulated. The up-regulation of HO-1 may contribute to the stress oxidative response in infected cells.
journal_name
Virus Resjournal_title
Virus researchauthors
Escalera-Cueto M,Medina-Martínez I,del Angel RM,Berumen-Campos J,Gutiérrez-Escolano AL,Yocupicio-Monroy Mdoi
10.1016/j.virusres.2014.11.010subject
Has Abstractpub_date
2015-01-22 00:00:00pages
105-12eissn
0168-1702issn
1872-7492pii
S0168-1702(14)00470-5journal_volume
196pub_type
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