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Poxviruses: past, present and future.

Abstract：

:The analysis of poxvirus genomes is complex, in part, because of their size (130-360 kb) and the fact that gene content is variable; a common set of 49 genes has been found in all sequenced poxviruses and an additional 41 genes are also present in all sequenced orthopoxviruses. As a group, poxviruses have a very broad range of eukaryotic hosts (including mammals, birds, reptiles and insects) and many poxvirus genes are associated with blocking host anti-viral responses. One consequence of this is that many poxvirus genes are not essential for growth in tissue culture and that extensive passaging in vitro results in the accumulation of mutations, including deletions that result in loss of gene function. Here, we review various comparative analyses of the poxviruses including gene prediction, gene conservation and function, genome organization, and poxvirus taxonomy and evolution.

journal_name

Virus Res

journal_title

Virus research

authors

Lefkowitz EJ,Wang C,Upton C

doi

10.1016/j.virusres.2006.01.016

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

105-18

issue

1

eissn

0168-1702

issn

1872-7492

pii

S0168-1702(06)00035-9

journal_volume

117

pub_type

杂志文章,评审

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