Abstract：
:VP28 and VP24 are two major envelope proteins of white spot syndrome virus (WSSV). The direct interaction between VP28 and VP24 has been described in previous studies. In this study, we confirmed this interaction and mapped the interaction domains of VP28 and VP24 by constructing a series of deletion mutants. By co-immunoprecipitation, two VP28-binding domains of VP24 were located at amino acid residues 46-61 and 148-160, while VP24-binding domain of VP28 was located at amino acid residues 31-45. These binding domains were further corroborated by peptide blocking assay, in which synthetic peptides spanning the binding domains were able to inhibit VP28-VP24 interaction, whereas same-size control peptides from non-binging regions did not.
journal_name
Virus Resjournal_title
Virus researchauthors
Li Z,Chen W,Xu L,Li F,Yang Fdoi
10.1016/j.virusres.2015.01.017subject
Has Abstractpub_date
2015-03-16 00:00:00pages
24-9eissn
0168-1702issn
1872-7492pii
S0168-1702(15)00027-1journal_volume
200pub_type
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