Abstract：
:The morbidity and mortality of coxsackievirus A10 (CVA10)-associated hand, foot, and mouth disease (HFMD) have been increasing in recent years, while few studies on the vaccine and animal model of CVA10 have been reported. Here, we first established a CVA10-infected gerbil model and employed it to evaluate the immunoprotective effect of an inactivated CVA10 vaccine. The results showed that gerbils up to the age of 14 days were fully susceptible to CVA10, and all died within five days post-infection by intraperitoneal inoculation. Lethargy, wasting, hind-limb paralysis, and even death could be observed in the CVA10-infected gerbils. Pathological examination suggested that CVA10 has a strong tropism toward muscle tissue, and muscle bundle fracture and muscular fibers necrosis were observed in the limb muscles. Additionally, active immunization results showed that gerbils immunized with the inactivated CVA10 vaccine were 100 % protected from lethal CVA10 challenge. The antisera from vaccinated gerbils also showed high neutralizing titers against CVA10. Based on these results, the CVA10-infected gerbil model was a suitable tool for analyzing the pathogenesis of CVA10 and assessing the protective efficacy of CVA10 candidate vaccines.
journal_name
Virus Resjournal_title
Virus researchauthors
Chen C,Xia Y,Zhu S,Xu F,Sun Y,Lu H,Gao M,Yang Z,Mao Z,Ge Q,Miao Z,Zhu H,Yao Pdoi
10.1016/j.virusres.2020.198067subject
Has Abstractpub_date
2020-09-01 00:00:00pages
198067eissn
0168-1702issn
1872-7492pii
S0168-1702(20)30116-7journal_volume
286pub_type
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