Abstract：
:Prion protein (PrP) has proven to bind amyloid beta (Aβ) oligomers with high affinity, changing our understanding of both prion diseases (PD) and Alzheimer's disease (AD) at the molecular and phenotypic levels, although the latter currently lacks sufficient attentions. Transgenic mice expressing anchorless PrP developed unusual diseases reminiscent of AD with tremendous amyloid plaque formation. In this review, we described two interesting observations at the phenotypic level. First, common pathogenic mutations of the PRNP gene in Gerstmann-Sträussler-Scheinker (GSS) syndrome were clustered at PrP95-105. Meanwhile, all nonsense PRNP mutations that generated soluble PrP 95-105 exhibited phenotypes with abundant amyloid formations. We speculate that PrP-Aβ oligomers binding might be the underlying mechanism of the predominant amyloid phenotypes. Second, soluble PrP-Aβ oligomer complexes might exist in the extracellular space at the beginning of both PD and AD and subserve an initial neuroprotective function. Thus, the diseases would only present after long-term accumulation. This might be the central common pathogenic event of both PD and AD.
journal_name
Virus Resjournal_title
Virus researchauthors
Li Bdoi
10.1016/j.virusres.2015.10.023subject
Has Abstractpub_date
2016-01-04 00:00:00pages
194-8eissn
0168-1702issn
1872-7492pii
S0168-1702(15)30102-7journal_volume
211pub_type
杂志文章,评审相关文献
VIRUS RESEARCH文献大全abstract：:To determine the evolutionary and phylodynamic history of DENV-1 in Guangdong, the strains detected between 1985 and 2015 were determined with phylogenetic and Bayesian analyses of the E gene. Three DENV-1 genotypes (I, V, and VI) were circulating in Guangdong, and genotype I was detected most frequently. The evolutio...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2018.07.005
更新日期：2018-09-02 00:00:00
abstract：:African swine fever virus (ASFV) is the etiological agent of a contagious and often lethal disease of domestic pigs that has significant economic consequences for the swine industry. The viral genome encodes for more than 150 genes, and only a select few of these genes have been studied in some detail. Here we report ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2016.07.013
更新日期：2016-09-02 00:00:00
abstract：:Mixed viral infections can induce different changes in symptom development, genome accumulation and tissue tropism. These issues were investigated for two phloem-limited begomoviruses, Abutilon mosaic virus (AbMV) and Tomato yellow leaf curl Sardinia virus (TYLCSV) in Nicotiana benthamiana plants doubly infected by ei...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2011.07.021
更新日期：2011-11-01 00:00:00
abstract：:Hepatitis B virus (HBV) surface antigen (HBsAg), which is encoded by the HBV S gene, is conventionally classified into 4 serological subtypes, adw, adr, ayw and ayr. To determine the relationship between the HBsAg seroreactivity and the nucleotide sequence diversity of the HBV S gene, the nucleotide sequences of S gen...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(95)00069-0
更新日期：1995-11-01 00:00:00
abstract：:The genetic and antigenic characteristics of the Amur (AMR) and Far East (FE) virus lineages, which are both within the genus Hantavirus, were studied. Representative viruses, H5 and B78 for AMR and Bao 14 for FE, were used. The entire small (S) and medium (M) segments, except for the 3'- and 5'-ends, were sequenced. ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2003.12.031
更新日期：2004-05-01 00:00:00
abstract：:All lepidopteran baculovirus genomes sequenced to date encode a viral fibroblast growth factor homolog (vFGF). Recently, we generated a Bombyx mori nucleopolyhedrovirus (BmNPV) mutant lacking functional vfgf and found that BmNPV vfgf contributes to virus virulence in B. mori larvae. However, the steps at which BmNPV v...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2008.06.002
更新日期：2008-10-01 00:00:00
abstract：:Dengue virus (DENV) infection associates with renal disorders. Patients with dengue hemorrhagic fever and acute kidney injury have a high mortality rate. Increased levels of cytokines may contribute to the pathogenesis of DENV-induced kidney injury. Currently, molecular mechanisms how DENV induces kidney cell injury h...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2014.12.007
更新日期：2015-02-02 00:00:00
abstract：:Bats are reservoir hosts of many zoonotic viruses and identification of viruses that they carry is important. This study aimed to use high throughput screening to identify the viruses in fecal guano of Taiwanese insectivorous bats caves in order to obtain more information on bat-derived pathogenic viruses in East Asia...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2018.10.020
更新日期：2019-01-02 00:00:00
abstract：:As agricultural acreage expanded and came to dominate landscapes across the world, viruses gained opportunities to move between crop and wild native plants. In the Midwestern USA, virus exchange currently occurs between widespread annual Poaceae crops and remnant native perennial prairie grasses now under consideratio...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2017.07.006
更新日期：2017-09-15 00:00:00
abstract：:Transplacental viral infections are dependent upon complex interactions between feto-placental and maternal immune responses and the stage of fetal development at which the infection occurs. Bovine viral diarrhea virus (BVDV) has the ability to cross the placenta and infect the fetus. Infection early in gestation with...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2012.05.018
更新日期：2012-08-01 00:00:00
abstract：:The disulphide-linked GP2/3/4 spike of equine arteritis virus (EAV) is essential for virus entry. We showed recently that in transfected cells carbohydrates attached adjacent to the signal peptide of GP3 inhibit cleavage. Here we confirm this unique phenomenon in recombinant viruses with disabled glycosylation sites. ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2014.02.005
更新日期：2014-04-01 00:00:00
abstract：:Coronaviruses are a large group of enveloped, single-stranded positive-sense RNA viruses that infect a wide range of avian and mammalian species, including humans. The emergence of deadly human coronaviruses, severe acute respiratory syndrome coronavirus (SARS-CoV), and Middle East respiratory syndrome coronavirus (ME...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/j.virusres.2014.11.021
更新日期：2015-04-16 00:00:00
abstract：:The human respiratory coronavirus OC43 was grown on a human rectal tumor cell line and was isotopically labeled with amino acids, glucosamine, and orthophosphate to analyze virion structural proteins. Four major protein species were resolved by electrophoresis and many of their properties were deduced from digestion s...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(86)90013-4
更新日期：1986-08-01 00:00:00
abstract：:Fifteen stable mouse spleen cell myeloma hybrids (hybridomas) producing monoclonal antibodies to rinderpest virus proteins were produced. The specificity of these monoclonal antibodies was established by radioimmunoprecipitation followed by polyacrylamide gel analysis and immunofluorescence. Nine antibodies were speci...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(89)90091-9
更新日期：1989-04-01 00:00:00
abstract：:Blackberry yellow vein disease (BYVD), a disorder caused by virus complexes, has become a major threat to fresh market blackberry production in the United States. Blackberry yellow vein associated virus (BYVaV) is the most prevalent virus in the BYVD complexes; detected in about 50% of samples exhibiting typical disea...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2012.07.009
更新日期：2012-10-01 00:00:00
abstract：:Porcine epidemic diarrhea virus (PEDV) has plagued the domestic swine industry in Korea causing significant economic impacts on pig production nationwide. In the present study, we determined the complete nucleotide sequences of the spike (S) glycoprotein genes of seven Korean PEDV isolates. The entire S genes of all i...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2010.01.015
更新日期：2010-05-01 00:00:00
abstract：:A recombinant baculovirus containing a cDNA which encodes haemagglutinin-neuraminidase (HN) of Newcastle disease virus (NDV) was constructed. Spodoptera frugiperda cells infected with this recombinant virus produced a large amount of HN glycoprotein similar to the authentic HN in size. The recombinant HN glycoprotein ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(91)90059-5
更新日期：1991-06-01 00:00:00
abstract：:The antigenic properties of 21 Japanese field isolates and two Australian strains of Akabane (AKA) virus (Simbu serogroup, bunyavirus) isolated from 1959 to 1990 were compared by enzyme-linked immunosorbent assay (ELISA), plaque-reduction neutralization (PRNT) and hemagglutination inhibition (HI) tests using monoclona...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(96)01415-3
更新日期：1997-02-01 00:00:00
abstract：:Subgroup J avian leukosis virus (ALV-J) is an oncogenic retrovirus primarily causing myeloid leukosis (ML) in broilers. Although ALV is well under control in a few countries including the USA, poultry industry in many parts of the world continues suffering from serious economic loss due to sporadic or widespread ALV i...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2012.07.003
更新日期：2012-10-01 00:00:00
abstract：:Human parainfluenza virus type 3 (HPIV3) fuses the viral envelope with the host cell membrane through the concerted action of the fusion (F) protein and the hemagglutinin-neuraminidase (HN). Upon HN binding to sialic acid (SA), the F protein in a metastable prefusion form is activated to undergo a series of structural...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2019.197791
更新日期：2020-01-02 00:00:00
abstract：:Reports of human infections with highly pathogenic H5N1 avian influenza viruses in many countries in Asia and Africa with varying case fatality rates highlight the pandemic potential of these viruses. In order to contain a rapidly spreading influenza virus in a pandemic scenario, a vaccine which can induce rapid and r...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2013.09.013
更新日期：2013-12-26 00:00:00
abstract：:Noncoding RNAs (ncRNAs) are key components of the transcriptome and play an important role in both normal biological activity and pathological processes such as viral infection and tumorigenesis. LncRNAs and miRNAs are the most important elements of ncRNAs and function as vital regulatory elements. Their complex regul...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/j.virusres.2018.08.018
更新日期：2018-09-15 00:00:00
abstract：:In present study, we report the first complete genomic sequence of pig bovine viral diarrhea (BVD) virus, that of strain ZM-95, which is 12,220 nucleotides long and contains short 5' and 3' non-coding regions and one open reading frame encoding a large polyprotein with 28 potential N-glycosylation sites (Asn-X-Ser or ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2006.05.005
更新日期：2006-12-01 00:00:00
abstract：:Immunisation of goats, mice, rats, rabbits, guinea pigs, and hamsters with the recombinant ectodomain of the porcine endogenous retrovirus (PERV) transmembrane envelope (TM) protein (p15E) induced binding and neutralising immune antibodies in all animals. In contrast, no antibodies were induced when pigs were immunise...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2015.05.019
更新日期：2015-10-02 00:00:00
abstract：:The first influenza pandemic of this century was declared in April of 2009, with the emergence of a novel H1N1 influenza A virus strain (H1N1pdm). Understanding the evolution of H1N1pdm populations within the South American region is essential for studying global diversification, emergence, resistance and vaccine effi...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2012.09.002
更新日期：2012-12-01 00:00:00
abstract：:There are over 350 million people chronically infected with the Hepatitis B virus (HBV); chronic HBV infections are associated with the development of hepatocellular carcinoma (HCC). While the precise mechanism of HBV-associated HCC remains undefined, it is believed to involve a combination of the host immune response...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2010.09.023
更新日期：2011-01-01 00:00:00
abstract：:The release of retrovirus particles from the infected cell is greatly stimulated by short motifs, known as "late" or "L" domains, present within the Gag precursor protein. Three distinct classes of L domains have been identified; these bear the core sequence: Pro-Thr/Ser-Ala-Pro [P(T/S)AP], Pro-Pro-x-Tyr (PPxY), or Ty...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/j.virusres.2004.08.007
更新日期：2004-12-01 00:00:00
abstract：:Application of bacteriophages and their lytic enzymes to control Clostridium perfringens is one potential approach to reduce the pathogen on poultry farms and in poultry-processing facilities. Bacteriophages lytic for C. perfringens were isolated from sewage, feces and broiler intestinal contents and ΦCPV1, a virulent...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2010.11.012
更新日期：2011-02-01 00:00:00
abstract：:Influenza A virus replication and packaging is mediated by cis-acting signals, which are located at the 3' and the 5' end of the viral segments. The terminal residues can be divided into conserved and nonconserved residues. We have constructed a mutant influenza A/WSN/33 virus, which contains multiple mutations in the...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(96)01335-4
更新日期：1996-09-01 00:00:00
abstract：:Human rabies cases have been on the rise during the past few years in China and a total of 2651 cases were reported in 2004. To better understand the current rabies epidemics in China, we isolated rabies viruses from dogs and humans from five provinces and characterized these isolates genetically by sequencing the ent...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2006.05.010
更新日期：2006-11-01 00:00:00
