Abstract：
:Hepatitis B virus (HBV) surface antigen (HBsAg), which is encoded by the HBV S gene, is conventionally classified into 4 serological subtypes, adw, adr, ayw and ayr. To determine the relationship between the HBsAg seroreactivity and the nucleotide sequence diversity of the HBV S gene, the nucleotide sequences of S genes for HBV isolates reported so far were aligned with each other. The numbers of nucleotide substitutions were then estimated by the 6-parameter method, and a phylogenetic tree was constructed by the unweighted paired grouping method with arithmetic mean (UPGMA) and the neighboring-joining (NJ) method. The phylogenetic trees constructed showed that all isolates were grouped into 4 genotypes (gyw, gdw-1, gdw-2, and gdr). More importantly, the genotypes did not necessarily correspond to the conventional serotypes. In particular, serotype 'adw' can be any of genotypes gdw-1, gdw-2, or gdr. Thus, genotyping by S genes gives more accurate information about genetic variation of HBV.
journal_name
Virus Resjournal_title
Virus researchauthors
Ohba K,Mizokami M,Ohno T,Suzuki K,Orito E,Lau JY,Ina Y,Ikeo K,Gojobori Tdoi
10.1016/s0168-1702(95)00069-0subject
Has Abstractpub_date
1995-11-01 00:00:00pages
25-34issue
1eissn
0168-1702issn
1872-7492pii
0168170295000693journal_volume
39pub_type
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