Detection of intersubtype recombinants with respect to env and nef genes of HIV-1 among female sex workers in Calcutta, India.

Abstract:

:HIV-1 detected among female sex workers in Calcutta, India was characterized in respect to env and nef genes. A total of 39 HIV-1 seropositive samples were used in the study. Phylogenetic analysis of the nucleotide sequences of respective regions showed that 22 out of 39 samples (56.4%) were infected with subtype C with respect to both env and nef genes; however, 17 samples (43.6%) showed distinct subtype discordance. Simplot analysis of these samples showed the presence of intersubtype recombination between subtypes C and B. Both env C/nef B and env B/nef C recombinants were found to be present; 16 samples were found to be env C/nef B and 1 sample was detected as env B/nef C. This result indicates the emergence of intersubtype recombinants of HIV-1 for the first time in this eastern part of India.

journal_name

Virus Res

journal_title

Virus research

authors

Bhanja P,Sengupta S,Banerjee D,Sarkar K,Jana S,Chakrabarti S

doi

10.1016/j.virusres.2007.06.013

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

310-4

issue

1-2

eissn

0168-1702

issn

1872-7492

pii

S0168-1702(07)00227-4

journal_volume

130

pub_type

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