Abstract:
:HIV-1 detected among female sex workers in Calcutta, India was characterized in respect to env and nef genes. A total of 39 HIV-1 seropositive samples were used in the study. Phylogenetic analysis of the nucleotide sequences of respective regions showed that 22 out of 39 samples (56.4%) were infected with subtype C with respect to both env and nef genes; however, 17 samples (43.6%) showed distinct subtype discordance. Simplot analysis of these samples showed the presence of intersubtype recombination between subtypes C and B. Both env C/nef B and env B/nef C recombinants were found to be present; 16 samples were found to be env C/nef B and 1 sample was detected as env B/nef C. This result indicates the emergence of intersubtype recombinants of HIV-1 for the first time in this eastern part of India.
journal_name
Virus Resjournal_title
Virus researchauthors
Bhanja P,Sengupta S,Banerjee D,Sarkar K,Jana S,Chakrabarti Sdoi
10.1016/j.virusres.2007.06.013subject
Has Abstractpub_date
2007-12-01 00:00:00pages
310-4issue
1-2eissn
0168-1702issn
1872-7492pii
S0168-1702(07)00227-4journal_volume
130pub_type
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