Abstract：
:The interaction between UV-B irradiation and cutaneous human papillomaviruses (HPV) has been suggested to be of relevance for the development of non-melanoma skin cancers. We investigated the activity within the upstream regulatory region (URR) of the HPV types 8, 38, 92, 93 and 96, as well as their responsiveness to UV-B irradiation and cellular differentiation. Promoter activities were higher in HaCaT than in SiHa cells, corresponding to the HPV tissue tropism. Transcriptional start sites were mapped at P(92) (HPV-38), P(45) (HPV-92), P(7439) (HPV-93) and P(256) (HPV-96). Transcription from HPV-8, 93 and 96 URR was up-regulated by cellular differentiation, linking the activity of these HPVs to the cellular state. UV-B irradiation activated HPV-8 but inhibited HPV-38 and HPV-93 whereas HPV-92 and 96 were not affected. As there are variable UV-B responses among the HPV types, further studies of interactions between UV-B and HPV need to consider the HPV type.
journal_name
Virus Resjournal_title
Virus researchauthors
Vasiljević N,Nielsen L,Doherty G,Dillner J,Forslund O,Norrild Bdoi
10.1016/j.virusres.2008.07.013subject
Has Abstractpub_date
2008-11-01 00:00:00pages
213-9issue
2eissn
0168-1702issn
1872-7492pii
S0168-1702(08)00278-5journal_volume
137pub_type
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