Abstract：
:Nipah virus, which was first recognized during an outbreak of encephalitis with high mortality in Peninsular Malaysia during 1998-1999, is most closely related to Hendra virus, another emergent paramyxovirus first recognized in Australia in 1994. We have studied the morphologic features of Nipah virus in infected Vero E6 cells and human brain by using standard and immunogold electron microscopy and ultrastructural in situ hybridization. Nipah virions are enveloped particles composed of a tangle of filamentous nucleocapsids and measured as large as 1900 nm in diameter. The nucleocapsids measured up to 1.67 microm in length and had the herringbone structure characteristic for paramyxoviruses. Cellular infection was associated with multinucleation, intracytoplasmic nucleocapsid inclusions (NCIs), and long cytoplasmic tubules. Previously undescribed for other members of the family Paramyxoviridae, infected cells also contained an inclusion formed of reticular structures. Ultrastructural ISH studies suggest these inclusions play an important role in the transcription process.
journal_name
Virus Resjournal_title
Virus researchauthors
Goldsmith CS,Whistler T,Rollin PE,Ksiazek TG,Rota PA,Bellini WJ,Daszak P,Wong KT,Shieh WJ,Zaki SRdoi
10.1016/s0168-1702(02)00323-4subject
Has Abstractpub_date
2003-03-01 00:00:00pages
89-98issue
1eissn
0168-1702issn
1872-7492pii
S0168170202003234journal_volume
92pub_type
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