Abstract：
:The cDNA of the nucleocapsid (core) protein of classical swine fever virus (CSFV) was generated by reverse transcription-polymerase chain reaction (RT-PCR) and cloned into a eukaryotic expression vector. The effect of the recombinant core protein on the transcriptional regulation of cellular as well as viral promoters was studied. Using transient transfection assay, our results demonstrated that the core protein can activate the promoter of human heat shock protein 70 gene, and suppressed the SV40 early promoter. These findings indicate that the core protein appears to function not only as a viral structural protein but also as a regulator of gene expression. The implications of core proteins on the viral maturation are discussed.
journal_name
Virus Resjournal_title
Virus researchauthors
Liu JJ,Wong ML,Chang TJdoi
10.1016/s0168-1702(97)00132-9subject
Has Abstractpub_date
1998-01-01 00:00:00pages
75-80issue
1eissn
0168-1702issn
1872-7492pii
S0168170297001329journal_volume
53pub_type
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