Abstract：
:Mosquito-borne alphaviruses are disseminated globally and cause febrile illness in humans and animals. Since the prevalence and diversity of alphaviruses has not been previously investigated in Zambia, reverse transcription PCR was employed as a broad-spectrum approach for the detection of alphaviruses in mosquitoes. From 552 mosquito pools, a novel alphavirus, tentatively named Mwinilunga alphavirus (MWAV), was discovered from a single Culex quinquefasciatus mosquito pool. The full genome of MWAV was subsequently determined, and pairwise comparisons demonstrated that MWAV represented a new alphavirus species. Phylogenetic analyses and a linear discriminant analysis based on the dinucleotide ratios in various virus sequences indicated that MWAV is related to a mosquito-specific alphavirus distinct from other known mosquito-borne alphaviruses due to its inability to replicate in vertebrate cell lines. Further analyses of these novel alphaviruses will help to facilitate a greater understanding of the molecular determinants of host range restriction and the evolutionary relationships of alphaviruses.
journal_name
Virus Resjournal_title
Virus researchauthors
Torii S,Orba Y,Hang'ombe BM,Mweene AS,Wada Y,Anindita PD,Phongphaew W,Qiu Y,Kajihara M,Mori-Kajihara A,Eto Y,Harima H,Sasaki M,Carr M,Hall WW,Eshita Y,Abe T,Sawa Hdoi
10.1016/j.virusres.2018.04.005subject
Has Abstractpub_date
2018-05-02 00:00:00pages
31-36eissn
0168-1702issn
1872-7492pii
S0168-1702(18)30098-4journal_volume
250pub_type
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