Cross-reactive and serospecific epitopes of nucleocapsid proteins of three hantaviruses: prospects for new diagnostic tools.

abstract：:Potato virus Y (PVY) is a member of the genus Potyvirus, family Potyviridae, is considered one of the most devastating pest affecting economically important crops, such as potato, tobacco, tomato and pepper, representing a serious threat due to high incidence and worldwide distribution. Its economic significance as we...

journal_title：Virus research

authors： Gómez MM,de Mello Volotão E,Assandri IR,Peyrou M,Cristina J

更新日期：2020-09-01 00:00:00

abstract：:Poliovirus (PV) infects susceptible cells through poliovirus receptor (PVR), which functions to bind virus and to convert its conformation. To study early infection process of PV, infection systems were employed using in vitro cultured cells and in vivo neural pathway of PVR transgenic (Tg) mice. For in vitro study, m...

journal_title：Virus research

authors： Arita M,Ohka S,Sasaki Y,Nomoto A

更新日期：1999-08-01 00:00:00

abstract：:The complete cDNA sequence corresponding to the genomic RNA of a South American strain of potato virus X (PVXc) is reported. The sequence (6432 nucleotides) contains five open reading frames coding for polypeptides with molecular weights of 165.3, 24.3, 12.3, 7.6 and 25.0 and displays an overall homology of 77.4% with...

journal_title：Virus research

authors： Orman BE,Celnik RM,Mandel AM,Torres HN,Mentaberry AN

更新日期：1990-07-01 00:00:00

abstract：:The immunopathogenesis of severe hand, foot and mouth disease (HFMD) remains elusive. This study revealed that enterovirus 71 (EV71) epitope-specific CD4+ T cell responses of HFMD patients were skewed toward a Th2 cytokine profile. Patients that demonstrated higher levels of IL-4 expression in their CD4 T cells follow...

journal_title：Virus research

authors： Wei R,Xu L,Zhang N,Zhu K,Yang J,Yang C,Deng C,Zhu Z,De Groot AS,Altmeyer R,Zeng M,Leng Q

更新日期：2013-10-01 00:00:00

abstract：:As master transcription factors for lipogenesis, sterol regulatory element-binding protein-1 (SREBP-1) has two isoforms, SREBP-1a and SREBP-1c. Hepatitis B virus X (HBx) can up-regulate the transcription of both SREBP-1a and SREBP-1c. HBx is a small protein consisting of 154 amino acids. Truncated forms of HBx, often ...

journal_title：Virus research

authors： Wu Q,Liu Q

更新日期：2015-12-02 00:00:00

abstract：:It was previously reported that during serial passage of a BHK-derived cell line persistently infected with foot-and-mouth disease virus, (termed C1-BHK-Rc1) the virus became increasingly more virulent for BHK-21 cells (de la Torre et al 1988). Virus strains isolated from different cell passage levels were tested for ...

journal_title：Virus research

authors： Díez J,Hofner M,Domingo E,Donaldson AI

更新日期：1990-12-01 00:00:00

abstract：:The highly heterogeneous porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent responsible for an economically important pig disease with the characteristic symptoms of reproductive losses in breeding sows and respiratory illnesses in young piglets. The virus can be broadly divided into th...

journal_title：Virus research

authors： Lu ZH,Archibald AL,Ait-Ali T

更新日期：2014-12-19 00:00:00

abstract：:Autophagy is an evolutionarily conserved lysosome-dependent degradation pathway that acts in the maintenance of cellular homeostasis and plays important functions in viral replication and pathogenesis. In this study, we investigated the role of autophagy in the replication of porcine reproductive and respiratory syndr...

journal_title：Virus research

authors： Chen Q,Fang L,Wang D,Wang S,Li P,Li M,Luo R,Chen H,Xiao S

更新日期：2012-02-01 00:00:00

abstract：:African horse sickness (AHS) is a devastating viral disease affecting equines and has resulted in many disastrous epizootics. To date, no successful therapeutic treatment exists for AHS, and commercially used live-attenuated vaccines have various undesirable side effects. Previous studies have shown that mice inoculat...

journal_title：Virus research

authors： Fearon SH,Dennis SJ,Hitzeroth II,Rybicki EP,Meyers AE

更新日期：2021-01-06 00:00:00

abstract：:Seneca Valley virus (SVV) is a novel Picornaviridae that is closely associated with porcine idiopathic vesicular disease (PIVD). Here, a novel SVV strain (CH-GX-01-2019) was detected and isolated from swine in Guangxi Province, China. The complete genomic sequence of CH-GX-01-2019 exhibited 93.3-98.9 % identify with o...

journal_title：Virus research

authors： Zhang J,Zhang H,Sun W,Jiao C,Xiao P,Han J,Nan F,Xie C,Ha Z,Li Z,Xie Y,Meng Y,Lu H,Jin N

更新日期：2021-01-02 00:00:00

abstract：:Damage to the Kupffer and endothelial cells of the liver sinusoids induced by the administration of sublethal doses of frog virus 3 (FV 3) renders A/J mice which are genetically resistant to mouse hepatitis virus type 3 (MHV 3) highly susceptible to this virus. Liver histopathology of these animals revealed typical ne...

journal_title：Virus research

authors： Pereira CA,Steffan AM,Kirn A

更新日期：1984-10-01 00:00:00

abstract：:The resurgence of Chikungunya virus (CHIKV) in the form of unprecedented explosive epidemic after a gap of 32 years in India is a point of major public health concern. In 2007 again there was outbreak in Kerala, India, affecting more than 25,000 cases with many reported mortalities. To understand the molecular basis o...

journal_title：Virus research

authors： Santhosh SR,Dash PK,Parida MM,Khan M,Tiwari M,Lakshmana Rao PV

更新日期：2008-07-01 00:00:00

abstract：:Viruses have evolved unique strategies and mechanisms to recruit ribosomes to ensure continued translation of their viral RNA during infection. The Dicistroviridae family of invertebrate viruses contains an unusual internal ribosome entry site (IRES), which can directly recruit ribosomes in the absence of initiation f...

journal_title：Virus research

authors： Jan E

更新日期：2006-07-01 00:00:00

abstract：:The identification of ligand-binding sites is often the first step in drug targeting and design. To date there are numerous computational tools available to predict ligand binding sites. These tools can guide or mitigate the need for experimental methods to identify binding sites, which often require significant resou...

journal_title：Virus research

authors： Brown JA,Espiritu MV,Abraham J,Thorpe IF

更新日期：2016-08-15 00:00:00

abstract：:In the past few decades, dengue has spread rapidly and is an emerging disease in China. An unexpected dengue outbreak occurred in Xishuangbanna, Yunnan, China, resulting in 1331 patients in 2013. In order to obtain the complete genome information and perform mutation and evolutionary analysis of causative agent relate...

journal_title：Virus research

authors： Wang X,Ma D,Huang X,Li L,Li D,Zhao Y,Qiu L,Pan Y,Chen J,Xi J,Shan X,Sun Q

更新日期：2017-06-15 00:00:00

abstract：:Recently, a novel deoxyribonucleic acid (DNA) virus, designated SEN virus (SENV), was discovered and strong associations between the two SENV variants (SENV-D and SENV-H) and non-A to E hepatitis were reported. To clarify the character of SENV infection in children, we investigated the detection rates of serum SENV DN...

journal_title：Virus research

authors： Sugiura T,Goto K,Imamine H,Ando T,Ban K,Sugiyama K,Togari H

更新日期：2004-03-15 00:00:00

abstract：:The glycoprotein (G) is the only surface protein of the lyssavirus particle and the only viral product known to be capable of eliciting the production of neutralizing antibodies. In this study, the isolation of escape mutants resistant to monoclonal antibody (Mab) neutralization was attempted by a selection strategy e...

journal_title：Virus research

authors： Fallahi F,Wandeler AI,Nadin-Davis SA

更新日期：2016-07-15 00:00:00

abstract：:Influenza A virus replication and packaging is mediated by cis-acting signals, which are located at the 3' and the 5' end of the viral segments. The terminal residues can be divided into conserved and nonconserved residues. We have constructed a mutant influenza A/WSN/33 virus, which contains multiple mutations in the...

journal_title：Virus research

authors： Bergmann M,Muster T

更新日期：1996-09-01 00:00:00

abstract：:Inhibition of the function of the M2 protein by amantadine can cause a conformational change in the haemagglutinin (HA) of H7 influenza A viruses and the consequent expression of the low pH form of the glycoprotein on the surface of virus-infected cells. Immunofluorescence studies showed that this conversion occurs sh...

journal_title：Virus research

authors： Ciampor F,Thompson CA,Grambas S,Hay AJ

更新日期：1992-03-01 00:00:00

abstract：:Influenza A (H1N1) virus, a high-risk infectious pathogen, can cause severe acute lung injury leading to significant morbidity and mortality. Angiotensin-converting enzyme 2 (ACE2), a negative regulator of the renin-angiotensin system (RAS), plays a protective role in pathogenesis of acute lung injury. Here, we showed...

journal_title：Virus research

authors： Liu X,Yang N,Tang J,Liu S,Luo D,Duan Q,Wang X

更新日期：2014-06-24 00:00:00

abstract：:DNAzyme is known to selectively cleave RNA at predetermined site. Transfection of Autographa californica nucleopolyhedrovirus (AcNPV) infected Sf9 cells with serine/threonine kinase (pk1) mRNA specific DNAzymes, DZ1 and DZ2 to cleave the viral coded (pk1) mRNA in between 87th and 88th, and 250th and 251st nucleotide, ...

journal_title：Virus research

authors： Mishra G,Chadha P,Chaudhury I,Das RH

更新日期：2008-07-01 00:00:00

abstract：:Two lines of LLC-MK2 cells persistently infected with human parainfluenza virus 3 (HPIV-3) have been maintained in culture for approximately 3 years. Subgenomic RNAs (putative defective interfering particle genomes) were detected in virions released from both persistently infected cultures. In one of the persistently ...

journal_title：Virus research

authors： Murphy DG,Dimock K,Kang CY

更新日期：1990-04-01 00:00:00

abstract：:Transplacental viral infections are dependent upon complex interactions between feto-placental and maternal immune responses and the stage of fetal development at which the infection occurs. Bovine viral diarrhea virus (BVDV) has the ability to cross the placenta and infect the fetus. Infection early in gestation with...

journal_title：Virus research

authors： Smirnova NP,Webb BT,Bielefeldt-Ohmann H,Van Campen H,Antoniazzi AQ,Morarie SE,Hansen TR

更新日期：2012-08-01 00:00:00

abstract：:We performed phylogenetic and cluster analysis of human rhinovirus species A (HRV-A) isolated from 76 children with acute respiratory infection in Yamagata prefecture, Japan during the period 2003-2007. Phylogenetic trees based on the nucleotide and amino acid sequences of the VP4/VP2 coding region showed that the pre...

journal_title：Virus research

authors： Mizuta K,Hirata A,Suto A,Aoki Y,Ahiko T,Itagaki T,Tsukagoshi H,Morita Y,Obuchi M,Akiyama M,Okabe N,Noda M,Tashiro M,Kimura H

更新日期：2010-02-01 00:00:00

abstract：:African swine fever virus (ASFV) is the etiological agent of a contagious and often lethal disease of domestic pigs that has significant economic consequences for the swine industry. The viral genome encodes for more than 150 genes, and only a select few of these genes have been studied in some detail. Here we report ...

journal_title：Virus research

authors： Borca MV,O'Donnell V,Holinka LG,Rai DK,Sanford B,Alfano M,Carlson J,Azzinaro PA,Alonso C,Gladue DP

更新日期：2016-09-02 00:00:00

abstract：:Genetic factors are presumed to influence the incidence of feline infectious peritonitis (FIP), especially among pedigreed cats. However, proof for the existence of such factors has been limited and mainly anecdotal. Therefore, we sought evidence for genetic susceptibility to FIP using feline high density single nucle...

journal_title：Virus research

authors： Golovko L,Lyons LA,Liu H,Sørensen A,Wehnert S,Pedersen NC

更新日期：2013-07-01 00:00:00

abstract：:Genome segments 1 and 2 of human group C rotavirus 'Bristol' strain were sequenced and their gene-protein coding properties assigned. This work completed the genome sequence of a human group C rotavirus (17,910 bp) and allowed the full gene-protein coding assignment of the 11 segments of dsRNA. Gene 1 is 3309 bp in si...

journal_title：Virus research

authors： Chen Z,Lambden PR,Lau J,Caul EO,Clarke IN

更新日期：2002-02-26 00:00:00

abstract：:The phylogenetic relationships of the hemagglutinin (HA) and non-structural (NS) genes from avian influenza (AI) H5 subtype viruses of North American origin are presented. Analysis of the HA genes of several previously uncharacterized isolates from waterfowl and turkeys provided clear evidence of significant sequence ...

journal_title：Virus research

authors： García M,Suarez DL,Crawford JM,Latimer JW,Slemons RD,Swayne DE,Perdue ML

更新日期：1997-10-01 00:00:00

abstract：:Recent reports indicated presence of two antigenic and genetic groups (genotypes VI and VII) of foot-and-mouth disease virus (FMDV) type A in India and are divergent from the vaccine strains. In order to choose suitable field isolate as candidate vaccine strain, anti-sera against representative isolates from both the ...

journal_title：Virus research

authors： Jangra RK,Tosh C,Sanyal A,Hemadri D,Bandyopadhyay SK

更新日期：2005-09-01 00:00:00

abstract：:Normal mouse lymphocytes were implanted with EBV receptors and exposed to the virus of P3HR-1 strain. 5% of the cells expressed early (EA) and viral capsid (VCA) antigens as assayed by immunofluorescence 24 h after the infection. Only 0.1% of cells expressed nuclear-like antigen (EBNA) 48 h post-infection. When labell...

journal_title：Virus research

authors： Sinangil F,Volsky DJ

更新日期：1984-01-01 00:00:00