Abstract：
:The immunopathogenesis of severe hand, foot and mouth disease (HFMD) remains elusive. This study revealed that enterovirus 71 (EV71) epitope-specific CD4+ T cell responses of HFMD patients were skewed toward a Th2 cytokine profile. Patients that demonstrated higher levels of IL-4 expression in their CD4 T cells following antigen stimulation in vitro tended to have a more prolonged period of high fevers and a longer duration of illness. Thus, an increase of EV71 epitope-specific Th2 type response may portend the poor prognosis for some HFMD patients.
journal_name
Virus Resjournal_title
Virus researchauthors
Wei R,Xu L,Zhang N,Zhu K,Yang J,Yang C,Deng C,Zhu Z,De Groot AS,Altmeyer R,Zeng M,Leng Qdoi
10.1016/j.virusres.2013.07.009subject
Has Abstractpub_date
2013-10-01 00:00:00pages
62-5issue
1eissn
0168-1702issn
1872-7492pii
S0168-1702(13)00231-1journal_volume
177pub_type
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