Abstract：
:Certain neurotropic viruses can invade the nervous system of their hosts and spread in chains of synaptically connected neurons. Consequently, it is possible to identify entire hierarchically connected circuits within an animal. In this review, we discuss the use of neurotropic herpesviruses as neuronal tract tracers. Although a variety of tract tracing viruses are available, each with its own unique infection characteristics, we focus on the widespread use of attenuated strains of pseudorabies virus (PRV), a swine herpesvirus with a broad host range. In particular, we focus on new applications of PRV for tract tracing including use of multiple infections by PRV reporter viruses to test for circuit convergence/divergence within the same animal. We provide examples of these combined application techniques within the context of an animal model to study the naturally occurring reversal of seasonal obesity in Siberian hamsters.
journal_name
Virus Resjournal_title
Virus researchauthors
Song CK,Enquist LW,Bartness TJdoi
10.1016/j.virusres.2005.04.012subject
Has Abstractpub_date
2005-08-01 00:00:00pages
235-49issue
2eissn
0168-1702issn
1872-7492pii
S0168-1702(05)00126-7journal_volume
111pub_type
杂志文章,评审相关文献
VIRUS RESEARCH文献大全abstract：:In situ hybridization and virus titration were used to characterize early stages of rat virus (RV) infection of rat pups after oronasal inoculation. Results suggest that virus enters through the lung and that early viremia leads rapidly to pantropic infection. Cells derived from all three germ layers were infected wit...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(93)90085-2
更新日期：1993-04-01 00:00:00
abstract：:Normal mouse lymphocytes were implanted with EBV receptors and exposed to the virus of P3HR-1 strain. 5% of the cells expressed early (EA) and viral capsid (VCA) antigens as assayed by immunofluorescence 24 h after the infection. Only 0.1% of cells expressed nuclear-like antigen (EBNA) 48 h post-infection. When labell...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(84)90016-9
更新日期：1984-01-01 00:00:00
abstract：:Bats are reservoir hosts of many zoonotic viruses and identification of viruses that they carry is important. This study aimed to use high throughput screening to identify the viruses in fecal guano of Taiwanese insectivorous bats caves in order to obtain more information on bat-derived pathogenic viruses in East Asia...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2018.10.020
更新日期：2019-01-02 00:00:00
abstract：:Nineteen distinct measles virus (MV) strains associated with nine different genotypes were identified in five Australian states (Victoria, New South Wales, Queensland, Northern Territory and Western Australia) between 1999 and 2001. One of the strains identified is likely to represent a new genotype within the clade D...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(02)00273-3
更新日期：2003-02-01 00:00:00
abstract：:A cDNA of the glycoprotein (G protein) gene of rabies virus Nishigahara strain was cloned and inserted into a baculovirus genome under the control of the polyhedrin promoter. Infection of Spodoptera frugiperda cells with this recombinant virus produced a large quantity of new protein instead of the parental polyhedrin...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(92)90095-q
更新日期：1992-09-01 00:00:00
abstract：:From the sera of patients with advanced cancer, a novel factor called SDF (serum-derived factor) was partially purified. SDF was shown to stimulate transcription from the long terminal repeat (LTR) of human immunodeficiency virus type 1 (HIV-1) by transient CAT assay. It did not stimulate gene expression of various co...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(93)90065-u
更新日期：1993-09-01 00:00:00
abstract：:A recombinant baculovirus, the genome of which contains DNA encoding Marek's disease virus serotype 1 (MDV1) homolog of glycoprotein D (gD) of herpes simplex virus under the polyhedrin promoter was constructed and designated rAcMDV1gD. Five monoclonal antibodies (MAbs) which recognize the MDV1 homolog of gD (MDV1 gD) ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(95)00063-v
更新日期：1995-10-01 00:00:00
abstract：:The biogeographical history of rabies can be reconstructed using molecular data. This work describes the genetic characterization of the Rabies virus variant that circulates in the Desmodus rotundus (vampire bat) population in an epizootic area and is transmitted to herbivorous livestock. The N and G genes of this vir...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2009.05.001
更新日期：2009-09-01 00:00:00
abstract：:Meliacine (MA), an antiviral principle present in partially purified leaf extracts of Melia azedarach L., prevents the development of herpetic stromal keratitis (HSK) in mice by diminishing the viral load in the eye and the severity of lesions caused by a virus-induced immunopathological reaction. The tetranortriterpe...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2008.12.013
更新日期：2009-04-01 00:00:00
abstract：:Crimean-Congo haemorrhagic fever virus (CCHFv) is a member of the genus Nairovirus in the family Bunyaviridae. It possesses a tripartite, single stranded RNA genome of negative polarity consisting of large (L), medium (M) and small (S) segments. CCHF virus is enzootic in life stock and wild animals in many parts of th...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2003.12.035
更新日期：2004-06-15 00:00:00
abstract：:The Sindbis viral expression system enables the rapid production of high levels of recombinant protein in mammalian cells; however, this expression is typically limited to transient production due to the cytotoxicity of the virus. Limiting the lethality inherent in the Sindbis virus vector in order to enable long term...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2008.12.019
更新日期：2009-04-01 00:00:00
abstract：:Oryctes rhinoceros nudivirus (OrNV) has been an effective biocontrol agent against the insect pest Oryctes rhinoceros (Coleoptera: Scarabaeidae) for decades, but there is evidence that resistance could be evolving in some host populations. We detected OrNV infection in O. rhinoceros from Solomon Islands and used Oxfor...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2020.197864
更新日期：2020-03-01 00:00:00
abstract：:The core proteins of epizootic haemorrhagic disease virus (EHDV) have important roles to perform in maintaining the structure and function of the virus. A complete genetic and phylogenetic analysis was therefore performed on these proteins (and the genes that code for them) to allow comparison of the selective pressur...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2009.07.011
更新日期：2009-11-01 00:00:00
abstract：:The coronavirus JHMV persistently infects rat Schwannoma cells RN2-2 at 32.5 degrees C and enters a host-imposed reversible, latent state at 39.5 degrees C. JHMV can remain up to 20 days in the latent state and about 14 days before the cultures lose the capacity to resume virus production upon return to 32.5 degrees C...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(85)90049-8
更新日期：1985-10-01 00:00:00
abstract：:MicroRNAs (miRNAs) play important roles in viral infections, especially by modulating the expression of cellular factors essential to viral replication or the host innate immune response to infection. To identify host miRNAs important to controlling porcine reproductive and respiratory syndrome virus (PRRSV) infection...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2014.08.012
更新日期：2015-01-02 00:00:00
abstract：:The aim of the present study was to analyze the influence of virus origin, mammalian or mosquito cell-derived, on antiviral susceptibility of DENV-2 to entry inhibitors and the association of this effect with any alteration in the mode of entry into the cell. To this end, ten serial passages of DENV-2 were performed i...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2014.02.011
更新日期：2014-05-12 00:00:00
abstract：:The interaction between UV-B irradiation and cutaneous human papillomaviruses (HPV) has been suggested to be of relevance for the development of non-melanoma skin cancers. We investigated the activity within the upstream regulatory region (URR) of the HPV types 8, 38, 92, 93 and 96, as well as their responsiveness to ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2008.07.013
更新日期：2008-11-01 00:00:00
abstract：:Tobacco (cv. Xanthi nn) plants were watered with allopurinol [4-hydroxypyrazolo (3,4-d) pyrimidine, HPP], a xanthine oxidoreductase (XOR) inhibitor, to investigate its effects on infection by Tobacco mosaic virus engineered to express the green fluorescent protein (TMV.GFP). TMV.GFP infection was monitored by examinat...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2008.05.018
更新日期：2008-11-01 00:00:00
abstract：:The transforming potential of DNA tumor viruses derives mainly from the ability of their encoded oncogene products to interact with cellular proteins. Many of these viral oncoproteins share regions of sequence similarity, designated conserved region 1 and 2, which have been implicated in complex formation with pRb, th...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(96)01404-9
更新日期：1997-01-01 00:00:00
abstract：:Recombinant clones containing all or portions of the bovine papillomavirus (BPV) upstream regulatory region (URR) were constructed. When analyzed by polyacrylamide gel electrophoresis, the cloned URR sequences exhibited electrophoretic properties characteristic of DNA containing bend sites. Two distinct bend centers w...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(89)90083-x
更新日期：1989-05-01 00:00:00
abstract：:It has been previously reported that the fp25K product of Bombyx mori nucleopolyhedrovirus (BmNPV) is required for post-mortem host degradation, but the mechanism by which it regulates host degradation is still unknown. This study shows that disruption of BmNPV fp25K attenuates the expression of viral cathepsin gene (...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2008.11.014
更新日期：2009-03-01 00:00:00
abstract：:The putative envelope glycoproteins of hepatitis C virus (HCV), E1 and E2, were expressed as recombinant, secretory proteins in Sf9 insect cells through infection with recombinant baculoviruses. The influenza virus hemagglutinin signal sequence (HASS) was inserted upstream of the HCV-cDNAs in order to effect secretion...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(96)01365-2
更新日期：1996-11-01 00:00:00
abstract：:Immunisation of goats, mice, rats, rabbits, guinea pigs, and hamsters with the recombinant ectodomain of the porcine endogenous retrovirus (PERV) transmembrane envelope (TM) protein (p15E) induced binding and neutralising immune antibodies in all animals. In contrast, no antibodies were induced when pigs were immunise...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2015.05.019
更新日期：2015-10-02 00:00:00
abstract：:Genetic characterization was conducted on 17 wild-type measles viruses isolated near Hanoi, Vietnam, during 1998 as well as on eight viruses isolated in the Hunan, Hainan, Shandong, and Anhui provinces of the People's Republic of China during 1995, 1998, and 1999. Previous studies had shown that, compared to wild-type...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(01)00268-4
更新日期：2001-09-01 00:00:00
abstract：:To investigate the evolutionary origins of proteins encoded by the Poxviridae family of viruses, we examined all poxvirus protein coding genes using a method of characterizing and visualizing the similarity between these proteins and taxonomic subsets of proteins in GenBank. Our analysis divides poxvirus proteins into...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2009.05.006
更新日期：2009-09-01 00:00:00
abstract：:Variants assigned to GI-23 lineage of infectious bronchitis virus (IBV), formerly called Var2, have circulated for nearly 20 years only in countries of the Middle East. Strains of this lineage were first identified in Israel in 1998. More severe form of the virus appeared in 2006, when the second wave of Var2 epidemic...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2017.09.010
更新日期：2017-10-15 00:00:00
abstract：:The surface antigen gene region from five chronic hepatitis B virus (HBV) infected chimpanzees was amplified by PCR and the sequence determined. Sequence comparison confirmed that all of the sequences were chimpanzee hepatitis B virus (chHBV) and they appeared to represent three distinct clusters or branches. To addre...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(01)00334-3
更新日期：2001-11-05 00:00:00
abstract：:Recent reports indicated presence of two antigenic and genetic groups (genotypes VI and VII) of foot-and-mouth disease virus (FMDV) type A in India and are divergent from the vaccine strains. In order to choose suitable field isolate as candidate vaccine strain, anti-sera against representative isolates from both the ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2005.03.021
更新日期：2005-09-01 00:00:00
abstract：:Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is recognized as one of the life-threatening viruses causing the most destructive pandemic in this century. The genesis of this virus is still unknown. To elucidate its molecular evolution and regulation of gene expression, the knowledge of codon usage is a...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2020.198113
更新日期：2020-10-15 00:00:00
abstract：:Poliovirus (PV) infects susceptible cells through poliovirus receptor (PVR), which functions to bind virus and to convert its conformation. To study early infection process of PV, infection systems were employed using in vitro cultured cells and in vivo neural pathway of PVR transgenic (Tg) mice. For in vitro study, m...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(99)00040-4
更新日期：1999-08-01 00:00:00
