Abstract：
:From the sera of patients with advanced cancer, a novel factor called SDF (serum-derived factor) was partially purified. SDF was shown to stimulate transcription from the long terminal repeat (LTR) of human immunodeficiency virus type 1 (HIV-1) by transient CAT assay. It did not stimulate gene expression of various control promoters including Rous sarcoma virus, human c-fos, c-myc, c-H-ras and chicken beta-actin genes. The SDF preparation did not contain any detectable TNF-alpha or TNF-beta, and differed in its physicochemical properties from TNFs. We concluded that SDF might be a novel factor associated with the clinical features of advanced cancer. It is speculated that SDF might have some role in disease progression of AIDS as well as in the development of the cachectic conditions in AIDS associated with malignancies.
journal_name
Virus Resjournal_title
Virus researchauthors
Ogiwara H,Nakamura T,Baba S,Okamoto Tdoi
10.1016/0168-1702(93)90065-usubject
Has Abstractpub_date
1993-09-01 00:00:00pages
255-65issue
3eissn
0168-1702issn
1872-7492pii
0168-1702(93)90065-Ujournal_volume
29pub_type
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