Abstract：
:Vesicular stomatitis virus (VSV) is a prototypic nonsegmented negative-strand RNA virus. VSV's broad cell tropism makes it a popular model virus for many basic research applications. In addition, a lack of preexisting human immunity against VSV, inherent oncotropism and other features make VSV a widely used platform for vaccine and oncolytic vectors. However, VSV's neurotropism that can result in viral encephalitis in experimental animals needs to be addressed for the use of the virus as a safe vector. Therefore, it is very important to understand the determinants of VSV tropism and develop strategies to alter it. VSV glycoprotein (G) and matrix (M) protein play major roles in its cell tropism. VSV G protein is responsible for VSV broad cell tropism and is often used for pseudotyping other viruses. VSV M affects cell tropism via evasion of antiviral responses, and M mutants can be used to limit cell tropism to cell types defective in interferon signaling. In addition, other VSV proteins and host proteins may function as determinants of VSV cell tropism. Various approaches have been successfully used to alter VSV tropism to benefit basic research and clinically relevant applications.
journal_name
Virus Resjournal_title
Virus researchauthors
Hastie E,Cataldi M,Marriott I,Grdzelishvili VZdoi
10.1016/j.virusres.2013.06.003subject
Has Abstractpub_date
2013-09-01 00:00:00pages
16-32issue
1-2eissn
0168-1702issn
1872-7492pii
S0168-1702(13)00206-2journal_volume
176pub_type
杂志文章,评审相关文献
VIRUS RESEARCH文献大全abstract：:To identify the parts of retroviral integrase that interact with its DNA substrates, we compared the patterns of target site usage by chimeric enzymes and protein fragments in assays that reveal integrase's non-specific nuclease activities. The central region of 12 chimeric proteins between the human immunodeficiency ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(99)00126-4
更新日期：2000-01-01 00:00:00
abstract：:The effect of three lysosomotropic compounds, chloroquine, monensin and NH4Cl, on the replication of foot-and-mouth disease virus (FMDV) type A12 was studied. Viral replication was almost totally inhibited by 0.5 mM chloroquine, 50 microM monensin, or 25 mM NH4Cl. Monensin and NH4Cl affected replication when added eit...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(87)90032-3
更新日期：1987-05-01 00:00:00
abstract：:Potato virus Y (PVY) is a member of the genus Potyvirus, family Potyviridae, is considered one of the most devastating pest affecting economically important crops, such as potato, tobacco, tomato and pepper, representing a serious threat due to high incidence and worldwide distribution. Its economic significance as we...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2020.198077
更新日期：2020-09-01 00:00:00
abstract：:Detection of Chronic bee paralysis virus (CBPV) is reported for the first time in two species of ants (Camponotus vagus and Formica rufa) and in Varroa destructor. A quantitative real-time PCR (qPCR) method was used to detect and quantify CBPV in infected bees, ants and mites. A minus-strand-specific RT-PCR was used t...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2007.12.011
更新日期：2008-05-01 00:00:00
abstract：:Aphid species were counted on citrus trees in orchards in Valencia, Spain, in the spring and autumn of 1997, 1998 and 1999. Moericke yellow water traps, the 'sticky shoot' method and counts of established colonies were used in extensive surveys in which 29,502 aphids were recorded and identified. Aphis spiraecola and ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2003.12.018
更新日期：2004-03-01 00:00:00
abstract：:Bovine herpesvirus-1 infected cell protein 27 (BICP27) was detected predominantly in the nucleolus. The open reading frame of BICP27 was fused with the enhanced yellow fluorescent protein (EYFP) gene to investigate its subcellular localization in live cells and BICP27 was able to direct monomeric, dimeric or trimeric ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2009.07.024
更新日期：2009-11-01 00:00:00
abstract：:We recently described a giant double stranded DNA virus called Mimivirus, isolated from amoebae, which might represent a new pneumonia-associated human pathogen. Its unique morphological and genomic characteristics allowed us to propose Mimivirus as a member of a new distinct Nucleocytoplasmic Large DNA viruses family...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/j.virusres.2005.07.011
更新日期：2006-04-01 00:00:00
abstract：:The highly heterogeneous porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent responsible for an economically important pig disease with the characteristic symptoms of reproductive losses in breeding sows and respiratory illnesses in young piglets. The virus can be broadly divided into th...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/j.virusres.2014.10.004
更新日期：2014-12-19 00:00:00
abstract：:SARS-CoV 3a protein was a unique protein of SARS coronavirus (SARS-CoV), which was identified in SARS-CoV infected cells and SARS patients' specimen. Recent studies revealed that 3a could interact specifically with many SARS-CoV structural proteins, such as M, E and S protein. Expressed 3a protein was reported to loca...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2005.01.001
更新日期：2005-05-01 00:00:00
abstract：:Peste-des-petits-ruminants virus (PPRV) (family Paramyxoviridae, genus Morbillivirus) causes an acute febrile illness in sheep and goats resulting in significant morbidity and mortality in infected herds. The paramyxoviruses all have negative sense, non-segmented RNA genomes and their host range and pathogenic determi...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2007.01.015
更新日期：2007-06-01 00:00:00
abstract：:Previous investigations suggest that the divergence of the group I alphabaculoviruses was later than that of the group II alphabaculoviruses, however, there is no quantitative data to support this hypothesis. To examine this theory, the evolutionary rates of the 30 core genes that are conserved among all baculoviruses...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2009.01.015
更新日期：2009-06-01 00:00:00
abstract：:The 'infectious DNA' approach, which is based on in vivo transcription of (+)RNA virus genome cDNA cassettes from eukaryotic promoters in transfected cells, became a popular alternative to the classical scheme in the infectious clone methodology. Its use, however, is often limited by the instability of plasmids due to...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(01)00371-9
更新日期：2001-12-04 00:00:00
abstract：:The phylogenetic diversity of classical swine fever virus (CSFV) in China has been extensively studied previously, with the report of the classification of Chinese CSFVs into four subgroups within two of the established genotypes, but the antigenic differences amongst Chinese CSF viruses still remain unknown. To addre...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2009.02.011
更新日期：2009-06-01 00:00:00
abstract：:Nineteen distinct measles virus (MV) strains associated with nine different genotypes were identified in five Australian states (Victoria, New South Wales, Queensland, Northern Territory and Western Australia) between 1999 and 2001. One of the strains identified is likely to represent a new genotype within the clade D...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(02)00273-3
更新日期：2003-02-01 00:00:00
abstract：:Rhabdoviruses cause devastating diseases in aquaculture, resulting in enormous economic losses. Our previous studies indicated that imidazole arctigenin derivatives possessed antiviral activities against aquatic rhabdoviruses. Based on the data of structure-activity relationship, a new imidazole arctigenin derivative,...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2020.198019
更新日期：2020-08-01 00:00:00
abstract：:Equine herpesvirus type 1 and 4 (EHV-1 and EHV-4) are important pathogens of horses worldwide. Infection with EHV-4 usually remains restricted to the upper respiratory tract, whereas infection with EHV-1 can generalize after leukocyte-associated viremia. Here we examined whether differences in the immunomodulatory gly...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2012.07.029
更新日期：2012-10-01 00:00:00
abstract：:Enterovirus 71 (EV71) is a single-stranded RNA virus that belongs to Picornaviridae family. It causes the hand-foot-and-mouth disease and fatal neurological diseases in young children and infants. The mechanism of EV71 pathogenesis remains obscure. The intestinal tract is the initial site of EV71 replication, but no o...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2013.05.002
更新日期：2013-09-01 00:00:00
abstract：:Recent reports indicated presence of two antigenic and genetic groups (genotypes VI and VII) of foot-and-mouth disease virus (FMDV) type A in India and are divergent from the vaccine strains. In order to choose suitable field isolate as candidate vaccine strain, anti-sera against representative isolates from both the ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2005.03.021
更新日期：2005-09-01 00:00:00
abstract：:Major progress in Dengue virus (DENV) biology has resulted from the use of infectious clones obtained through reverse genetics. The construction of these clones is commonly based on high- or low-copy number plasmids, yeast artificial chromosomes, yeast-Escherichia coli shuttle vectors, and bacterial artificial chromos...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2013.12.001
更新日期：2014-02-13 00:00:00
abstract：:MicroRNAs play vital roles in regulating the battle between pathogens and host cells during viral challenging. MiR-4331 aggravates transmissible gastroenteritis virus (TGEV) -induced mitochondrial damage, also suppresses transcription of TGEV gene 7 via targeting cellular CDCA7. Otherwise, miR-4331-5p affects H1N1/200...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2020.198064
更新日期：2020-09-01 00:00:00
abstract：:The paramyxo- and pneumoviruses are members of the order Mononegavirales, a group of viruses with non-segmented, negative strand RNA genomes. The polymerases of these viruses are multi-functional complexes, capable of transcribing subgenomic capped and polyadenylated mRNAs and replicating the genome. Although there is...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/j.virusres.2017.01.008
更新日期：2017-04-15 00:00:00
abstract：:Puumala (PUU) viruses are the predominant etiologic agents of hantavirus infections in Europe. The most important reservoir is the bank vole, Clethrionomys glareolus (Cg), belonging to the subfamily Arvicolinae of the Muridae family. Here we report on the molecular characterization of the first rodent-derived sequence...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(99)00024-6
更新日期：1999-06-01 00:00:00
abstract：:Primers corresponding to conserved regions in the RNA-dependent RNA polymerase and the RACE procedure led to the cloning of the complete sweetpotato mild mottle virus (SPMMV) RNA genome. The assembled SPMMV genomic sequence was 10,818 nucleotides in length with a polyadenylated tract at the 3' terminus. The structure ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(97)00148-2
更新日期：1998-02-01 00:00:00
abstract：:Post-translational modifications (PTMs) are the chemical modifications of proteins after translation, and are very important to guarantee the proper biological functions of these proteins. Baculoviruses are pathogenic viruses that infect invertebrates and have large circular double-stranded DNA genomes. Many proteins ...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/j.virusres.2020.197865
更新日期：2020-04-02 00:00:00
abstract：:Coronaviruses are a large group of enveloped, single-stranded positive-sense RNA viruses that infect a wide range of avian and mammalian species, including humans. The emergence of deadly human coronaviruses, severe acute respiratory syndrome coronavirus (SARS-CoV), and Middle East respiratory syndrome coronavirus (ME...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/j.virusres.2014.11.021
更新日期：2015-04-16 00:00:00
abstract：:In the early 1970s, the Chinese Equine Infectious Anemia Virus (EIAV) vaccine, EIAV(DLA), was developed through successive passages of a wild-type virulent virus (EIAV(L)) in donkeys in vivo and then in donkey macrophages in vitro. EIAV attenuation and cell tropism adaptation are associated with changes in both envelo...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2007.04.005
更新日期：2007-09-01 00:00:00
abstract：:In alfalfa samples analyzed by hightroughput sequencing, four de novo assembled contigs encoding gene products showing identities to alphapartitiviruses proteins were found based on BlastX analysis. The predicted amino acid (aa) sequences of two contigs presented 99-100% identity to the RNA-dependent RNA polymerase (R...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2019.03.021
更新日期：2019-05-01 00:00:00
abstract：:The fusion (F) proteins of 10 strains of bovine respiratory syncytial virus (BRSV) were compared by radioimmunoprecipitation with fractionation on SDS-polyacrylamide gels. Two different molecular weights (15 kDa and 20 kDa) of the F2 proteins were demonstrated among the BRSV strains tested. To delineate the molecular ...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(93)90059-v
更新日期：1993-08-01 00:00:00
abstract：:The human poliovirus receptor (PVR) is a cell surface protein with a multitude of functions in human biology. PVR was initially identified as the receptor for the human poliovirus and recent discoveries have given a greater insight into both its morphology and its function. Alternative splicing of the PVR gene results...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/j.virusres.2017.09.001
更新日期：2017-10-15 00:00:00
abstract：:Murine cytomegalovirus (MCMV) m137 null mutants, Deltam137A and Deltam137B, were generated by inserting a gpt cassette into a deleted region of the open reading frame. A polyclonal antiserum produced to an Escherichia coli expressed gst-m137 fusion protein was used to show that a 38 kDa polypeptide corresponding to th...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(02)00024-2
更新日期：2002-03-20 00:00:00
