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Bombyx mori nucleopolyhedrovirus FP25K is essential for maintaining a steady-state level of v-cath expression throughout the infection.

Abstract：

:It has been previously reported that the fp25K product of Bombyx mori nucleopolyhedrovirus (BmNPV) is required for post-mortem host degradation, but the mechanism by which it regulates host degradation is still unknown. This study shows that disruption of BmNPV fp25K attenuates the expression of viral cathepsin gene (v-cath) at a late stage of infection, and thus reduces the secretion of its product V-CATH. Western blot analysis showed that secretion of V-CATH was severely reduced in BmN cells and B. mori larvae infected with Bm25KD, a BmNPV mutant lacking functional fp25K, compared to that of wild-type BmNPV. Also, reduced accumulation of pro-V-CATH in Bm25KD-infected cells was observed from 4 days postinfection (dpi), during which V-CATH was first detected in the medium of BmNPV-infected cells. qRT-PCR experiments showed that the expression levels of v-cath mRNA in wild-type- and Bm25KD-infected BmN cells were comparable at 3 dpi, but showed a marked decrease in Bm25KD-infected BmN cells at 4 dpi. Collectively, these results suggest that BmNPV FP25K is essential for the proper transcriptional regulation of v-cath and efficient secretion of V-CATH, and a steady-state level of v-cath expression during the period of V-CATH secretion (after 4 dpi) is required for post-mortem host degradation.

journal_name

Virus Res

journal_title

Virus research

authors

Katsuma S,Nakanishi T,Shimada T

doi

10.1016/j.virusres.2008.11.014

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

155-60

issue

1-2

eissn

0168-1702

issn

1872-7492

pii

S0168-1702(08)00408-5

journal_volume

140

pub_type

杂志文章

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