当前位置： SCI文献检索 > VIRUS RESEARCH期刊下所有文献 > Phylogenetic relationships of Irkut and West Caucasian bat viruses within the Lyssavirus genus and suggested quantitative criteria based on the N gene sequence for lyssavirus genotype definition.

Phylogenetic relationships of Irkut and West Caucasian bat viruses within the Lyssavirus genus and suggested quantitative criteria based on the N gene sequence for lyssavirus genotype definition.

Abstract：

:The nucleoprotein (N), phosphoprotein (P) and glycoprotein (G) genes of Irkut and West Caucasian bat viruses (WCBV) were sequenced and compared with those of other lyssaviruses. N gene nucleotide identities provided unequivocal separation of all lyssavirus genotypes with an identity threshold of 82%. On this basis, Irkut virus should be considered as a new genotype with particular relatedness to genotypes 4 and 5 (78.0-78.6% identity for N gene nucleotides and 90.4-92.6% for amino acids). Furthermore, genotypes 4-6, together with Aravan, Khujand and Irkut viruses, present a solid phylogroup of Old World bat lyssaviruses. This relationship is apparent using all three viral genes, and causes overlap between intragenotype and intergenotype identities for the P gene (Aravan, Khujand viruses and genotype 6) and for the G gene (Aravan, Khujand, genotypes 5 and 6). WCBV is the most divergent of known lyssaviruses with only limited relatedness to genotypes 2 and 3.

journal_name

Virus Res

journal_title

Virus research

authors

Kuzmin IV,Hughes GJ,Botvinkin AD,Orciari LA,Rupprecht CE

doi

10.1016/j.virusres.2005.03.008

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

28-43

issue

1

eissn

0168-1702

issn

1872-7492

pii

S0168-1702(05)00072-9

journal_volume

111

pub_type

杂志文章

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