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Quasispecies and its impact on viral hepatitis.

Abstract：

:Quasispecies dynamics mediates adaptability of RNA viruses through a number of mechanisms reviewed in the present article, with emphasis on the medical implications for the hepatitis viruses. We discuss replicative and non-replicative molecular mechanisms of genome variation, modulating effects of mutant spectra, and several modes of viral evolution that can affect viral pathogenesis. Relevant evolutionary events include the generation of minority virus variants with altered functional properties, and alterations of mutant spectrum complexity that can affect disease progression or response to treatment. The widespread occurrence of resistance to antiviral drugs encourages new strategies to control hepatic viral disease such as combination therapies and lethal mutagenesis. In particular, ribavirin may be exerting in some cases its antiviral activity with participation of its mutagenic action. Despite many unanswered questions, here we document that quasispecies dynamics has provided an interpretation of the adaptability of the hepatitis viruses, with features conceptually similar to those observed with other RNA viruses, a reflection of the common underlying Darwinian principles.

journal_name

Virus Res

journal_title

Virus research

authors

Domingo E,Gomez J

doi

10.1016/j.virusres.2007.02.001

subject

Has Abstract

pub_date

2007-08-01 00:00:00

pages

131-50

issue

2

eissn

0168-1702

issn

1872-7492

pii

S0168-1702(07)00041-X

journal_volume

127

pub_type

杂志文章,评审

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