Evidence for a polytopic form of the E1 envelope glycoprotein of Hepatitis C virus.

abstract：:Non-structural protein1β (Nsp1β) of porcine reproductive and respiratory syndrome virus (PRRSV) has been recognized to be involved in suppressing the host innate immune response and mediating viral subgenomic mRNA transcription. In the present study, we have analyzed the interaction of Nsp1β of Chinese highly pathogen...

journal_title：Virus research

authors： Wang L,He Q,Gao Y,Guo X,Ge X,Zhou L,Yang H

更新日期：2012-10-01 00:00:00

abstract：:Coronavirus genome replication is mediated by a multi-subunit protein complex that is comprised of more than a dozen virally encoded and several cellular proteins. Interactions of the viral replicase complex with cis-acting RNA elements located in the 5' and 3'-terminal genome regions ensure the specific replication o...

journal_title：Virus research

authors： Madhugiri R,Fricke M,Marz M,Ziebuhr J

更新日期：2014-12-19 00:00:00

abstract：:We have investigated the infection of Aedes albopictus (mosquito) cell clones by Sindbis virus. Variation in the multiplicity of infection (MOI) from ranges of 50-0.00005 pfu/cell was determined to have no effect on the progression of the infection to high acute phase titer, suggesting that intracellular factors alone...

journal_title：Virus research

authors： Karpf AR,Blake JM,Brown DT

更新日期：1997-07-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) infection indirectly induces activation-dependent apoptosis in bystander immune CD4+ T-cells, a hallmark of AIDS pathogenesis. It is well known that this pathogenetic event is significantly correlated with a high virus load. Active viral replication occurs in HIV-1 asymptoma...

journal_title：Virus research

authors： Ikuta K,Kameoka M,Luftig RB

更新日期：1997-12-01 00:00:00

abstract：:Forty Chinese PCV2 strains collected between 2004 and 2008 were sequenced and their genetic variations were analyzed together with nine previous PCV2 isolates. Phylogenetic analysis indicated that these Chinese PCV2 strains could be divided into four genotypes (PCV-2a, PCV-2b, PCV-2d and PCV-2e), and the genotype PCV-...

journal_title：Virus research

authors： Wang F,Guo X,Ge X,Wang Z,Chen Y,Cha Z,Yang H

更新日期：2009-10-01 00:00:00

abstract：:It has been previously reported that the fp25K product of Bombyx mori nucleopolyhedrovirus (BmNPV) is required for post-mortem host degradation, but the mechanism by which it regulates host degradation is still unknown. This study shows that disruption of BmNPV fp25K attenuates the expression of viral cathepsin gene (...

journal_title：Virus research

authors： Katsuma S,Nakanishi T,Shimada T

更新日期：2009-03-01 00:00:00

abstract：:The measles virus induces a life-long immune response associated with antibodies specific for the fusion protein. To map the linear immunodominant recognition sites of the fusion (F) protein of the measles virus, we have reacted a complete set of 108 overlapping pentadecapeptides with purified IgG obtained from donor ...

journal_title：Virus research

authors： Muller CP,Handtmann D,Brons NH,Weinmann M,Wiesmüller KH,Spahn G,Wiesneth M,Schneider F,Jung G

更新日期：1993-12-01 00:00:00

abstract：:The human respiratory coronavirus OC43 was grown on a human rectal tumor cell line and was isotopically labeled with amino acids, glucosamine, and orthophosphate to analyze virion structural proteins. Four major protein species were resolved by electrophoresis and many of their properties were deduced from digestion s...

journal_title：Virus research

authors： Hogue BG,Brian DA

更新日期：1986-08-01 00:00:00

abstract：:This paper characterises a virulent strain (CB/05) of canine coronavirus (CCoV) isolated from the internal organs of pups that had died of a systemic disease without evidence of other common canine pathogens. High viral RNA titres were detected in the internal organs by a real-time RT-PCR assay specific for CCoV type ...

journal_title：Virus research

authors： Decaro N,Martella V,Elia G,Campolo M,Desario C,Cirone F,Tempesta M,Buonavoglia C

更新日期：2007-04-01 00:00:00

abstract：:It was previously reported that during serial passage of a BHK-derived cell line persistently infected with foot-and-mouth disease virus, (termed C1-BHK-Rc1) the virus became increasingly more virulent for BHK-21 cells (de la Torre et al 1988). Virus strains isolated from different cell passage levels were tested for ...

journal_title：Virus research

authors： Díez J,Hofner M,Domingo E,Donaldson AI

更新日期：1990-12-01 00:00:00

abstract：:Sixty-six human enterovirus serotypes have been described using antibody neutralization, with antigenic variants defined within several serotypes. Despite the availability of sequence data for numerous enteroviruses, the molecular basis of serotype is unknown. Previous studies by others have identified four major phyl...

journal_title：Virus research

authors： Oberste MS,Maher K,Pallansch MA

更新日期：1998-11-01 00:00:00

abstract：:To characterize the genomic mutations of hepatitis E virus (HEV) during consecutive passages associated with adaptation to growth in cell culture, a cloned genotype 3 HEV [pJE03-1760F/wt, starting virus (SV)] was passaged 10 times in A549 cells, and the entire genomic sequence of the passage 10 (P10) progeny was deter...

journal_title：Virus research

authors： Nagashima S,Kobayashi T,Tanaka T,Tanggis,Jirintai S,Takahashi M,Nishizawa T,Okamoto H

更新日期：2016-09-02 00:00:00

abstract：:A fragment of DNA from within the minimum transforming region (mtr-1) of herpes simplex virus type 1 (HSV-1) is known to raise the mutation frequency of cells. This activity has been attributed to a viral protein whose properties are largely unknown. Antiserum was raised to a synthetic peptide of a predicted amino aci...

journal_title：Virus research

authors： Das CM,Zhang S,Shillitoe EJ

更新日期：1994-11-01 00:00:00

abstract：:We here report the results of an investigation of the effect of interferon on the establishment of new infections by a retrovirus. For this study, we used an infectious but replication-incompetent retrovirus carrying a drug-resistance gene and assayed for infectivity by measuring drug-resistant colony formation. Mouse...

journal_title：Virus research

authors： Kumar R,Sen GC

更新日期：1989-08-01 00:00:00

abstract：:Human adenoviruses have been used for mammalian expression vectors and recombinant vaccines for heterologous antigens. We constructed and characterized an infectious adenovirus recombinant containing core-E1-E2 genes of hepatitis C virus (HCV). The core protein was produced mainly during the early phase of viral infec...

journal_title：Virus research

authors： Seong YR,Lee CH,Im DS

更新日期：1998-06-01 00:00:00

abstract：:The effect of three lysosomotropic compounds, chloroquine, monensin and NH4Cl, on the replication of foot-and-mouth disease virus (FMDV) type A12 was studied. Viral replication was almost totally inhibited by 0.5 mM chloroquine, 50 microM monensin, or 25 mM NH4Cl. Monensin and NH4Cl affected replication when added eit...

journal_title：Virus research

authors： Baxt B

更新日期：1987-05-01 00:00:00

abstract：:The glycoprotein (G) is the only surface protein of the lyssavirus particle and the only viral product known to be capable of eliciting the production of neutralizing antibodies. In this study, the isolation of escape mutants resistant to monoclonal antibody (Mab) neutralization was attempted by a selection strategy e...

journal_title：Virus research

authors： Fallahi F,Wandeler AI,Nadin-Davis SA

更新日期：2016-07-15 00:00:00

abstract：:The compound LPRP-Et-97543 was isolated from Liriope platyphylla roots and was observed to have potential anti-viral effects in HepG2.2.15 cells against hepatitis B virus (HBV). The antiviral mode was further clarified, and the HBV-transfected Huh7 cells were used as the platform. During viral gene expression, LPRP-Et...

journal_title：Virus research

authors： Huang TJ,Tsai YC,Chiang SY,Wang GJ,Kuo YC,Chang YC,Wu YY,Wu YC

更新日期：2014-11-04 00:00:00

abstract：:We recently described a giant double stranded DNA virus called Mimivirus, isolated from amoebae, which might represent a new pneumonia-associated human pathogen. Its unique morphological and genomic characteristics allowed us to propose Mimivirus as a member of a new distinct Nucleocytoplasmic Large DNA viruses family...

journal_title：Virus research

authors： Suzan-Monti M,La Scola B,Raoult D

更新日期：2006-04-01 00:00:00

abstract：:Sequence analyses of VP3 gene segments of Wongorr virus isolates from the Northern Territory of Australia were compared with the cognate gene segments from Picola and Paroo River viruses. Previous serological investigations had demonstrated some relationships between these viruses, however VP3 gene sequence and phylog...

journal_title：Virus research

authors： Parkes H,Gould AR

更新日期：1996-10-01 00:00:00

abstract：:To identify the parts of retroviral integrase that interact with its DNA substrates, we compared the patterns of target site usage by chimeric enzymes and protein fragments in assays that reveal integrase's non-specific nuclease activities. The central region of 12 chimeric proteins between the human immunodeficiency ...

journal_title：Virus research

authors： Katzman M,Sudol M,Pufnock JS,Zeto S,Skinner LM

更新日期：2000-01-01 00:00:00

abstract：:Between 2006 and 2009, 10 field experiments were done at Kununurra, Carnarvon or Medina in Western Australia (WA) which have tropical, sub-tropical and Mediterranean climates, respectively. These experiments investigated the effectiveness of cultural control measures in limiting ZYMV spread in pumpkin, and single-gene...

journal_title：Virus research

authors： Coutts BA,Kehoe MA,Jones RA

更新日期：2011-08-01 00:00:00

abstract：:The phylogenetic diversity of classical swine fever virus (CSFV) in China has been extensively studied previously, with the report of the classification of Chinese CSFVs into four subgroups within two of the established genotypes, but the antigenic differences amongst Chinese CSF viruses still remain unknown. To addre...

journal_title：Virus research

authors： Zhu Y,Shi Z,Drew TW,Wang Q,Qiu H,Guo H,Tu C

更新日期：2009-06-01 00:00:00

abstract：:Raccoons (Procyon lotor), which are not native to Japan, have been suspected to transmit various pathogens by frequent intrusion into agricultural and residential areas. To determine influenza A virus seropositivity in raccoons in Japan, we examined a total of 634 raccoons captured in 19 towns (A-S) from 2009 to 2012....

journal_title：Virus research

authors： Yamaguchi E,Sashika M,Fujii K,Kobayashi K,Bui VN,Ogawa H,Imai K

更新日期：2014-08-30 00:00:00

abstract：:The effect of mild heat shock on the replication of human cytomegalovirus (HCMV) was studied in human embryo fibroblasts. Treatment of cell cultures at 44 degrees C for 10 min just before infection or at 24 h post infection (p.i.) shortened HCMV eclipse period and enhanced viral replication, while heat shock performed...

journal_title：Virus research

authors： Zerbini M,Musiani M,La Placa M

更新日期：1986-12-01 00:00:00

abstract：:A cell-free system was developed to study the replication of simian rotavirus SA11. The components of the system included (i) subviral particles prepared from infected cells to template the synthesis of viral RNA and (ii) an mRNA-dependent rabbit reticulocyte lysate to support protein synthesis. Based upon nuclease-se...

journal_title：Virus research

authors： Patton JT

更新日期：1986-12-01 00:00:00

abstract：:A temperature-sensitive mutant of the Moloney murine leukemia virus-TB, ts1, causes hindlimb paralysis and immunodeficiency in mice. At the restrictive temperature, the envelope precursor polyprotein, gPr80env, is inefficiently processed intracellularly, and this is associated with the neurovirulence of ts1. To test t...

journal_title：Virus research

authors： Yu Y,Kamps CA,Yuen PH,Wong PK

更新日期：1991-03-01 00:00:00

abstract：:Polyomavirus-infected cells express three proteins in the early phase of the lytic cycle, the so-called tumor antigens. Two of them, large- and middle-T antigens, are also required for virus-mediated transformation of primary cells, while middle-T alone is sufficient to transform established cells in culture. Cell tra...

journal_title：Virus research

authors： Hofer U,Wehrle B,Ballmer-Hofer K

更新日期：1995-02-01 00:00:00

abstract：:Since 2002 there has been a rise in arthrogryposis/hydranencephaly (AGH) incidence in Israel, caused by Akabane (AKA) and, possibly, Aino viruses. To test the ability to control the disease, three siRNA genes targeted to the S genome segment were designed and prepared in the form of siRNA cassettes. For the design all...

journal_title：Virus research

authors： Levin A,Kutznetova L,Kahana R,Rubinstein-Guini M,Stram Y

更新日期：2006-09-01 00:00:00

abstract：:The capsid structures of the 7 serotypes of foot-and-mouth disease virus have been compared utilizing a series of neutralizing monoclonal antibodies which were previously shown to recognize at least 4 distinct epitopes on type A12 virus. A radioimmune binding assay using radioactively labeled antigens and the monoclon...

journal_title：Virus research

authors： Grubman MJ,Morgan DO

更新日期：1986-10-01 00:00:00