Abstract：
:The capsid structures of the 7 serotypes of foot-and-mouth disease virus have been compared utilizing a series of neutralizing monoclonal antibodies which were previously shown to recognize at least 4 distinct epitopes on type A12 virus. A radioimmune binding assay using radioactively labeled antigens and the monoclonal antibodies revealed that certain conformation dependent epitopes are conserved among A subtypes, while some continuous epitopes are conserved among A subtypes as well as other FMDV serotypes. On the basis of differential reactivity among other FMDV subtypes and serotypes two additional epitopes have been defined on the A12 particle. Binding and neutralization assays revealed that the presence and function of an epitope are not necessarily correlated.
journal_name
Virus Resjournal_title
Virus researchauthors
Grubman MJ,Morgan DOdoi
10.1016/0168-1702(86)90055-9subject
Has Abstractpub_date
1986-10-01 00:00:00pages
33-43issue
1eissn
0168-1702issn
1872-7492pii
0168-1702(86)90055-9journal_volume
6pub_type
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