Abstract：
:Small interfering RNAs (siRNAs) have been shown to direct sequence-specific inhibition of gene expression in mammalian cells. siRNAs are RNA duplexes of 21-23 nucleotides (nts) with approximately 2nt 3' overhangs that can induce degradation of their homologous target mRNAs without interferon responses in mammalian cells. The degradation of the target occurs at the post-transcriptional level, meaning a post-transcriptional gene silencing (PTGS) mechanism called as RNA interference (RNAi). RNAi has emerged as an efficient method to inhibit gene expression in mammalian cells with increasingly successful cases of knockdown of many specific genes. Recent works have shown that the use of RNAi could inhibit HIV-1 replication by targeting viral or cellular genes. RNAi can be considered as a gene-specific therapeutic option for controlling HIV-1 replication. However, the control of HIV-1 replication has become complex because of the limited effectiveness of existing anti-HIV-1 agents and the high speed mutation rate of the HIV-1 genome. Careful assessments are required for the potential of RNAi as a gene therapy approach for controlling HIV-1 replication. This review will discuss the status of the science using RNAi for controlling HIV-1 replication and will describe possible problems for therapeutic applications of RNAi-mediated technologies for HIV-1 behind this novel mechanism.
journal_name
Virus Resjournal_title
Virus researchauthors
Lee NS,Rossi JJdoi
10.1016/j.virusres.2004.01.015subject
Has Abstractpub_date
2004-06-01 00:00:00pages
53-8issue
1eissn
0168-1702issn
1872-7492pii
S0168170204000322journal_volume
102pub_type
杂志文章,评审相关文献
VIRUS RESEARCH文献大全abstract：:Raccoons (Procyon lotor), which are not native to Japan, have been suspected to transmit various pathogens by frequent intrusion into agricultural and residential areas. To determine influenza A virus seropositivity in raccoons in Japan, we examined a total of 634 raccoons captured in 19 towns (A-S) from 2009 to 2012....
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2014.05.004
更新日期：2014-08-30 00:00:00
abstract：:The coat protein (CP) is the only structural protein present in the polyprotein of bean common mosaic virus. The well known characteristics of the CP are self-oligomerization and nucleic acid binding activity. The studies of the coat protein mutants revealed that the oligomeric property of CP solely depends on the ami...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2019.197755
更新日期：2019-11-01 00:00:00
abstract：:The rabies viruses that circulate in Arctic countries and in much of northern and central Asia are phylogenetically closely related and collectively referred to as the Arctic/Arctic-like (AL) lineage. The emergence and spread of this lineage is of significant interest given that rabies remains a serious zoonotic disea...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2011.10.026
更新日期：2012-01-01 00:00:00
abstract：:Utilizing the reverse transcriptase-polymerase chain reaction (RT-PCR) procedure, we have synthesized full-length copies of segment 10 from African horsesickness virus (AHSV) serotypes 1, 4 and 8. The genes were cloned, sequenced and compared with the sequence of the cognate gene from AHSV serotypes 3 and 9. Sequences...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(94)90052-3
更新日期：1994-08-01 00:00:00
abstract：:Monocotyledonous plant infecting mastreviruses (family Geminiviridae) have been found in the Old World. The greatest diversity of these viruses has been found in Africa but this may simply reflect the more extensive sampling that has been done there. To provide a better understanding of mastrevirus diversity in Austra...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2012.07.018
更新日期：2012-10-01 00:00:00
abstract：:The mild climate of the Salinas Valley, CA lends itself well to a diverse agricultural industry. However, the diversity of weeds, crops and insect and fungal vectors also provide favorable conditions for plant virus disease development. This paper considers the incidence and management of several plant viruses that ha...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/s0168-1702(00)00196-9
更新日期：2000-11-01 00:00:00
abstract：:Hepatitis C virus (HCV) is a major cause of global morbidity and mortality, with an estimated 130-150 million infected individuals worldwide. HCV is a leading cause of chronic liver diseases including cirrhosis and hepatocellular carcinoma. Current treatment options in developing countries involve pegylated interferon...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2016.07.008
更新日期：2016-09-02 00:00:00
abstract：:The release of retrovirus particles from the infected cell is greatly stimulated by short motifs, known as "late" or "L" domains, present within the Gag precursor protein. Three distinct classes of L domains have been identified; these bear the core sequence: Pro-Thr/Ser-Ala-Pro [P(T/S)AP], Pro-Pro-x-Tyr (PPxY), or Ty...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/j.virusres.2004.08.007
更新日期：2004-12-01 00:00:00
abstract：:Rat theilovirus (RTV) is a cardiovirus related to Theiler's murine encephalomyelitis virus. While RTV is a prevalent viral pathogen of rats used in biomedical research, the pathogenesis and characterization of RTV infections is not well understood. In the studies reported herein, we used immunohistochemistry to identi...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2011.07.014
更新日期：2011-09-01 00:00:00
abstract：:Recent evidence has accumulated which definitively shows that chemokine receptors CCR5 and CXCR4 play an essential role as coreceptors for human immunodeficiency virus type 1 (HIV-1) infection. Flow cytometric analysis permitted us to detect CD38, a surface marker of early differentiation, as well as activation of T c...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(00)00220-3
更新日期：2001-01-01 00:00:00
abstract：:As a member of the BamHI-A rightward transcripts family of the Epstein-Barr virus (EBV), RPMS1 expression has been confirmed in all EBV-associated tumors. However, few studies have investigated the single-nucleotide polymorphisms (SNPs) of RPMS1, and only one SNP site (g155391a) has been reported to be associated with...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2018.04.009
更新日期：2018-05-02 00:00:00
abstract：:We describe a rapid method for genetic characterisation of influenza virus genes using reverse transcription and amplification by polymerase chain reaction (RT/PCR) of all virus segments simultaneously (multiplex RT/PCR) using primers based on the conserved terminal sequences. The product has been shown to be suitable...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(94)90087-6
更新日期：1994-06-01 00:00:00
abstract：:A study of the evolutionary relationships of GLRaV-4,-5,-6 and -9, and two new Ampelovirus isolates (GLRaV-Pr and -De) related to grapevine leafroll disease was conducted based on molecular variability, positive selection analysis and maximum likelihood phylogenetic reconstructions. Sequences corresponding to the N-te...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2008.02.015
更新日期：2008-07-01 00:00:00
abstract：:Cell lines were constructed which permanently express influenza virus-specific RNA. Two approaches were followed. C127 cells were transformed with bovine papilloma virus (BPV) vectors and the resulting cell lines were found to inhibit the replication of influenza virus at low multiplicity of infection (MOI 0.05). Howe...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(89)90035-x
更新日期：1989-10-01 00:00:00
abstract：:Human torovirus (HTV) and Breda virus (BRV), members of the genus torovirus in the family Coronaviridae, are established infectious agents of humans and cattle, respectively. The hemagglutinin-esterase (HE) gene of Breda virus serotype 2 (BRV-2) has been identified and the nucleotide sequence for BRV serotype 1 (BRV-1...
journal_title：Virus research
pub_type： 杂志文章,收录出版
doi：10.1016/s0168-1702(99)00088-x
更新日期：1999-11-01 00:00:00
abstract：:Sixty-six human enterovirus serotypes have been described using antibody neutralization, with antigenic variants defined within several serotypes. Despite the availability of sequence data for numerous enteroviruses, the molecular basis of serotype is unknown. Previous studies by others have identified four major phyl...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(98)00101-4
更新日期：1998-11-01 00:00:00
abstract：:Inhibition of the function of the M2 protein by amantadine can cause a conformational change in the haemagglutinin (HA) of H7 influenza A viruses and the consequent expression of the low pH form of the glycoprotein on the surface of virus-infected cells. Immunofluorescence studies showed that this conversion occurs sh...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/0168-1702(92)90056-f
更新日期：1992-03-01 00:00:00
abstract：:Marek's disease virus (MDV) is an oncogenic herpesvirus that causes a disease in chickens characterized by tumor formation and immunosuppression. In this paper, we identified differentially expressed proteins in the bursa of Fabricius of chickens infected with the highly virulent MDV strain RB1B, using two-dimensional...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2010.08.010
更新日期：2010-11-01 00:00:00
abstract：:We have found that an HIV-1 accessory gene product Vpr enhanced HIV-1 reproduction in U1 cells chiefly by the induction of TNF, a proinflammatory cytokine, which was also known to be an activator of HIV-1 reproduction. We have generated the functional HIV-1 accessory gene product Vpr in bacterial cells. Vpr was genera...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(02)00230-7
更新日期：2002-12-01 00:00:00
abstract：:Tick-borne encephalitis (TBE) is a serious human neurological disease caused by TBE virus (TBEV). However, the mechanisms of TBEV-caused pathogenesis remain unclear. The endoplasmic reticulum (ER) stress response, also defined as the unfolded protein response (UPR), is an important conserved molecular signaling pathwa...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2013.10.012
更新日期：2013-12-26 00:00:00
abstract：:Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is recognized as one of the life-threatening viruses causing the most destructive pandemic in this century. The genesis of this virus is still unknown. To elucidate its molecular evolution and regulation of gene expression, the knowledge of codon usage is a...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2020.198113
更新日期：2020-10-15 00:00:00
abstract：:Lepidopteran nucleopolyhedroviruses have distinct viral tissue tropisms in host larvae. We previously identified the Bm8 gene of Bombyx mori nucleopolyhedrovirus (BmNPV), the product of which inhibits viral propagation in the middle silk gland (MSG). However, it is unknown whether this inhibitory function of the Bm8 p...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2018.03.011
更新日期：2018-04-02 00:00:00
abstract：:Noroviruses (NoVs) are a leading cause of non-bacterial acute gastroenteritis worldwide. The prevalence of Genogroup II, genotype 3 (GII.3) NoVs is secondary to the epidemic GII.4 strains which show broad spectrum binding activities against multiple types of histo-blood group antigens (HBGAs). In our previous study it...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2016.08.006
更新日期：2016-09-15 00:00:00
abstract：:Satellite RNAs (satRNAs) and viroids belong to the group called subviral agents and are the smallest pathogens of plants. In general, small satRNAs and viroids are 300-400 nt in size and do not encode any functional proteins; they are thus regarded as so-called long noncoding RNAs (lncRNAs). These lncRNAs are receivin...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/j.virusres.2015.06.016
更新日期：2016-01-02 00:00:00
abstract：:The E2 glycoprotein of classical swine fever virus (CSFV) is involved in viral infection and induction of neutralizing antibodies. Little is known about how E2 interacts with host cells. To understand the cellular factors involved in viral replication cycle, E2 was used as bait in yeast two-hybrid screens, resulting i...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2013.10.016
更新日期：2014-01-22 00:00:00
abstract：:Transplacental viral infections are dependent upon complex interactions between feto-placental and maternal immune responses and the stage of fetal development at which the infection occurs. Bovine viral diarrhea virus (BVDV) has the ability to cross the placenta and infect the fetus. Infection early in gestation with...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2012.05.018
更新日期：2012-08-01 00:00:00
abstract：:Double-stranded RNA viruses infecting bacterial hosts belong to the Cystoviridae family. Bacteriophage phi6 is one of the best characterized dsRNA viruses and shares structural as well as functional similarities with other well-studied eukaryotic dsRNA viruses (e.g. L-A, rotavirus, bluetongue virus, and reovirus). The...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/j.virusres.2003.12.009
更新日期：2004-04-01 00:00:00
abstract：:Porcine enteric coronaviruses (CoVs) cause severe disease in the porcine herds worldwide, leading to important economic losses. Despite the knowledge of these viruses since the 1970s, vaccination strategies have not been implemented, leading to continuous re-emergence of novel virulent strains. Live attenuated vaccine...
journal_title：Virus research
pub_type： 杂志文章,评审
doi：10.1016/j.virusres.2016.07.003
更新日期：2016-12-02 00:00:00
abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) replication and transcription activator (RTA) is necessary and sufficient for the switch from KSHV latency to lytic replication. RTA activates promoters by several mechanisms. RTA can bind to sequences in viral promoters and activate transcription. In addition, RTA intera...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/j.virusres.2007.07.019
更新日期：2008-01-01 00:00:00
abstract：:We have previously identified an inhibitory, 57 nt AU-rich sequence in the HPV-1 late 3' UTR, termed as the HPV-1 AU-rich element (h1ARE). It contains two types of functionally important motifs: two AUUUA sequences and three UUUUU sequences. We have shown that the h1ARE interacts with heterogeneous nuclear ribonucleop...
journal_title：Virus research
pub_type： 杂志文章
doi：10.1016/s0168-1702(00)00238-0
更新日期：2001-03-01 00:00:00
