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Retrovirus budding.

Abstract：

:The release of retrovirus particles from the infected cell is greatly stimulated by short motifs, known as "late" or "L" domains, present within the Gag precursor protein. Three distinct classes of L domains have been identified; these bear the core sequence: Pro-Thr/Ser-Ala-Pro [P(T/S)AP], Pro-Pro-x-Tyr (PPxY), or Tyr-Pro-x-Leu (YPxL). A number of recent studies have demonstrated that L domains function by interacting with components of the machinery responsible for sorting cellular proteins into the multivesicular body (MVB) pathway. This review traces the history of L domain discovery and characterization, and highlights the relationship between L domain activity, retrovirus release, and the host endosomal sorting machinery.

journal_name

Virus Res

journal_title

Virus research

authors

Demirov DG,Freed EO

doi

10.1016/j.virusres.2004.08.007

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

87-102

issue

2

eissn

0168-1702

issn

1872-7492

pii

S0168-1702(04)00318-1

journal_volume

106

pub_type

杂志文章,评审

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