Abstract：
:Porcine reproductive and respiratory syndrome (PRRS) is a major disease affecting pigs worldwide and resulting in considerable economic losses. While PRRS is a global phenomenon, the causative viruses PRRSV-1 (first detected in Europe) and PRRSV-2 (isolated in North America) are genetically and biologically distinct. In addition, the disease outcome is directly linked to co-infections associated with the porcine respiratory disease complex and the host response is variable between different breeds of pigs. It is therefore warranted when studying the pathogenesis of PRRS to consider each viral genotype separately and apply careful consideration to the disease model studied. We here review the respiratory pig model for PRRSV-1, with a focus on a recent set of studies conducted with carefully selected virus strains and pigs, which may serve as both a baseline and benchmark for future investigation.
journal_name
Virus Resjournal_title
Virus researchauthors
Salguero FJ,Frossard JP,Rebel JM,Stadejek T,Morgan SB,Graham SP,Steinbach Fdoi
10.1016/j.virusres.2014.12.026subject
Has Abstractpub_date
2015-04-16 00:00:00pages
135-43eissn
0168-1702issn
1872-7492pii
S0168-1702(14)00540-1journal_volume
202pub_type
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