Cis-active RNA elements (CREs) and picornavirus RNA replication.

abstract：:Viruses are strict intracellular pathogens that require the cellular environment to complete a successful infection. Among them, African swine fever virus (ASFV) is an evolutionary ancient DNA virus, endemic in Africa, which is nowadays causing an emergent disease in Europe with a potential high economic impact in the...

journal_title：Virus research

authors： Muñoz-Moreno R,Galindo I,Cuesta-Geijo MÁ,Barrado-Gil L,Alonso C

更新日期：2015-11-02 00:00:00

abstract：:The coronavirus disease 2019 (COVID-19) pandemic has created an urgent need for therapeutics that inhibit the SARS-COV-2 virus and suppress the fulminant inflammation characteristic of advanced illness. Here, we describe the anti-COVID-19 potential of PTC299, an orally bioavailable compound that is a potent inhibitor ...

journal_title：Virus research

authors： Luban J,Sattler RA,Mühlberger E,Graci JD,Cao L,Weetall M,Trotta C,Colacino JM,Bavari S,Strambio-De-Castillia C,Suder EL,Wang Y,Soloveva V,Cintron-Lue K,Naryshkin NA,Pykett M,Welch EM,O'Keefe K,Kong R,Goodwin E,Jac

更新日期：2021-01-15 00:00:00

abstract：:A study of the evolutionary relationships of GLRaV-4,-5,-6 and -9, and two new Ampelovirus isolates (GLRaV-Pr and -De) related to grapevine leafroll disease was conducted based on molecular variability, positive selection analysis and maximum likelihood phylogenetic reconstructions. Sequences corresponding to the N-te...

journal_title：Virus research

authors： Maliogka VI,Dovas CI,Katis NI

更新日期：2008-07-01 00:00:00

abstract：:Sixty-six human enterovirus serotypes have been described using antibody neutralization, with antigenic variants defined within several serotypes. Despite the availability of sequence data for numerous enteroviruses, the molecular basis of serotype is unknown. Previous studies by others have identified four major phyl...

journal_title：Virus research

authors： Oberste MS,Maher K,Pallansch MA

更新日期：1998-11-01 00:00:00

abstract：:In order to investigate the functional properties of the UL56 gene of herpes simplex virus type 1 (HSV-1), it was necessary to express the UL56 protein in vitro. The DNA sequences corresponding to the open reading frame of the UL56 gene of HSV-1 strain F were amplified from genomic viral DNA by PCR using primers corre...

journal_title：Virus research

authors： Kehm R,Lorentzen E,Rösen-Wolff A,Darai G

更新日期：1994-07-01 00:00:00

abstract：:The inner capsid protein VP6 of group A rotavirus possesses group and subgroup epitope specificities. Avian rotaviruses have a unique VP6 that is antigenically different from its mammalian counterpart. The lack of information on the VP6 protein of chicken rotavirus strain, CH2, at the genetic and antigenic level was a...

journal_title：Virus research

authors： Buragohain M,Cherian SS,Prabhakar G,Chitambar SD

更新日期：2008-11-01 00:00:00

abstract：:To gain more insights into the epidemiology of hantaviruses in China, the hantaviral S, M and L segment sequences were recovered from two Microtus fortis captured in Shenyang and four M. fortis trapped in Yuanjiang in China. Genetic analysis revealed that Shenyang sequences are closely related to the sequences of Fuso...

journal_title：Virus research

authors： Zou Y,Xiao QY,Dong X,Lv W,Zhang SP,Li MH,Plyusnin A,Zhang YZ

更新日期：2008-10-01 00:00:00

abstract：:Viral vectors are important vehicles in vaccine research. Avipoxviruses including fowlpox virus (FPV) play major roles in viral vaccine vector development for the prevention and therapy of human and other veterinary diseases due to their immunomodulatory effects and safety profile. Recently, we analyzed the genomic an...

journal_title：Virus research

authors： Du S,Liu C,Zhu Y,Wang Y,Ren D,Wang M,Tan P,Li X,Tian M,Zhang Y,Li J,Zhao F,Li C,Jin N

更新日期：2015-02-02 00:00:00

abstract：:There are currently no effective drugs to treat serious complications caused by WNV infection. The inhibition of WNV by the pluripotent immunomodulator AS101 [ammonium trichloro(dioxyethylene-0-0')tellurate] was evaluated in vitro and in vivo, and its mechanism was explored. Adding AS101 to Vero cells 1h or 5 min befo...

journal_title：Virus research

authors： Indenbaum V,Bin H,Makarovsky D,Weil M,Shulman LM,Albeck M,Sredni B,Mendelson E

更新日期：2012-06-01 00:00:00

abstract：:Porcine reproductive and respiratory syndrome virus (PRRSV), an arterivirus, belongs to a group of RNA viruses that are cytopathic for macrophages and establish persistent infections. Apoptosis is the presumed mechanism of cell death in monkey kidney cell lines and porcine alveolar macrophages after infection with Eur...

journal_title：Virus research

authors： Kim TS,Benfield DA,Rowland RR

更新日期：2002-05-10 00:00:00

abstract：:Positive-strand RNA viruses exist as a quasi-species due to the incorporation of mutations into the viral genome during replication by the virus-encoded RNA-dependent RNA polymerase (RdRP). Therefore, the RdRP is often described as a low-fidelity enzyme. However, until recently, a complete description of the kinetic, ...

journal_title：Virus research

authors： Castro C,Arnold JJ,Cameron CE

更新日期：2005-02-01 00:00:00

abstract：:Comprehensive pathogenesis studies on Peste des Petits Ruminants virus (PPRV) have been delayed so far by the absence of a small animal model reproducing the disease or an in vitro biological system revealing virulence differences. In this study, a mouse 10T1/2 cell line has been identified as presenting different sus...

journal_title：Virus research

authors： Comerlato J,Albina E,Puech C,Franco AC,Minet C,Eloiflin RJ,Rodrigues V,Servan de Almeida R

更新日期：2020-09-01 00:00:00

abstract：:Over the past three decades diseases caused by whitefly-transmitted geminiviruses (begomoviruses) have emerged to be important constraints to the production of solanaceous crops, particularly tomato (Solanum lycopersicum) and peppers (Capsicum spp.), in many tropical and subtropical regions of the world. The most stud...

journal_title：Virus research

authors： Kenyon L,Tsai WS,Shih SL,Lee LM

更新日期：2014-06-24 00:00:00

abstract：:Dengue (Den) viruses cause apoptosis in mammalian cells, but usually result in high progeny yields without evident damage in mosquito cells. By using subtractive hybridization, 13 potentially virus-induced genes were selected in Den-2 virus-infected Aedes albopictus C6/36 cells. Based on semi-quantitative and real-tim...

journal_title：Virus research

authors： Lin CC,Yang CF,Tu CH,Huang CG,Shih YT,Chuang CK,Chen WJ

更新日期：2007-03-01 00:00:00

abstract：:The generation of a new panel of 32 monoclonal antibodies (MAbs) reactive with the P protein of the raccoon strain of rabies virus is described. Through a series of analyses employing competitive ELISA and immunoblotting, these MAbs were classified into eight groups, each defining an antigenic site, thereby increasing...

journal_title：Virus research

authors： Nadin-Davis SA,Fehlner-Gardiner C,Sheen M,Wandeler AI

更新日期：2010-09-01 00:00:00

abstract：:The nucleotide sequence of the E-3 region genes, the hexon associated protein pVIII genes, and part of the fiber genes coding for the N-terminal tail regions, of porcine adenovirus (PAV) types 1 and 2 were determined. The sizes of the E-3 regions were found to be 1162 and 1222 bp, respectively. The five open reading f...

journal_title：Virus research

authors： Reddy PS,Idamakanti N,Derbyshire JB,Nagy E

更新日期：1996-08-01 00:00:00

abstract：:In this study we demonstrated that Macrobrachium rosenbergii nodavirus (MrNV) was able to internalize and replicate in Sf9 insect cells, with levels of infection altered by substances affecting the caveolin-(CAV) mediated endocytosis pathway. The use of Sf9 cells for efficient MrNV replication and propagation was demo...

journal_title：Virus research

authors： Somrit M,Watthammawut A,Chotwiwatthanakun C,Weerachatyanukul W

更新日期：2016-09-02 00:00:00

abstract：:Transmissible spongiform encephalopathies (TSE) are a heterogeneous group of neurodegenerative disorders. The common feature of these diseases is the pathological conversion of the normal cellular prion protein (PrP(C)) into a β-structure-rich conformer-termed PrP(Sc). The latter can induce a self-perpetuating process...

journal_title：Virus research

authors： Le NT,Narkiewicz J,Aulić S,Salzano G,Tran HT,Scaini D,Moda F,Giachin G,Legname G

更新日期：2015-09-02 00:00:00

abstract：:In alfalfa samples analyzed by hightroughput sequencing, four de novo assembled contigs encoding gene products showing identities to alphapartitiviruses proteins were found based on BlastX analysis. The predicted amino acid (aa) sequences of two contigs presented 99-100% identity to the RNA-dependent RNA polymerase (R...

journal_title：Virus research

authors： Bejerman N,Debat H,Nome C,Cabrera-Mederos D,Trucco V,de Breuil S,Lenardon S,Giolitti F

更新日期：2019-05-01 00:00:00

abstract：:Transposable elements are valuable for somatic and germ-line transformation. However, long interspersed nuclear elements (LINEs) have not been used because of poor information on the transposition mechanism. We have developed a novel gene delivery system combining baculovirus AcNPV and two silkworm LINEs, SART1 and R1...

journal_title：Virus research

authors： Kawashima T,Osanai M,Futahashi R,Kojima T,Fujiwara H

更新日期：2007-07-01 00:00:00

abstract：:Employing the yeast two-hybrid system, the Tat protein of the human immunodeficiency virus (HIV) was shown to interact with a region spanning the EGF-like repeats 1-6 of the mouse Notch1, the human Notch2 and the Drosophila Notch. This observation was confirmed in mammalian cells by demonstrating an interaction betwee...

journal_title：Virus research

authors： Shoham N,Cohen L,Yaniv A,Gazit A

更新日期：2003-12-01 00:00:00

abstract：:Canine distemper virus (CDV) is a major pathogen of dogs and represents a serious threat to both unvaccinated and vaccinated animals. This study surveyed dogs with or without clinical signs related to canine distemper from different regions of Brazil from 2008 to 2012. A total of 155 out of 386 animals were found to b...

journal_title：Virus research

authors： Budaszewski Rda F,Pinto LD,Weber MN,Caldart ET,Alves CD,Martella V,Ikuta N,Lunge VR,Canal CW

更新日期：2014-02-13 00:00:00

abstract：:Utilizing the reverse transcriptase-polymerase chain reaction (RT-PCR) procedure, we have synthesized full-length copies of segment 10 from African horsesickness virus (AHSV) serotypes 1, 4 and 8. The genes were cloned, sequenced and compared with the sequence of the cognate gene from AHSV serotypes 3 and 9. Sequences...

journal_title：Virus research

authors： de Sá RO,Zellner M,Grubman MJ

更新日期：1994-08-01 00:00:00

abstract：:St. Louis encephalitis virus (SLEV), a flavivirus transmitted to humans by Culex mosquitoes, causes clinical symptoms ranging from acute febrile disorder to encephalitis. To reach the central nervous system (CNS) from circulating blood, the pathogen must cross the blood-brain barrier formed by endothelial cells and as...

journal_title：Virus research

authors： Zuza AL,Barros HL,de Mattos Silva Oliveira TF,Chávez-Pavoni JH,Zanon RG

更新日期：2016-06-02 00:00:00

abstract：:Peste-des-petits-ruminants virus (PPRV) (family Paramyxoviridae, genus Morbillivirus) causes an acute febrile illness in sheep and goats resulting in significant morbidity and mortality in infected herds. The paramyxoviruses all have negative sense, non-segmented RNA genomes and their host range and pathogenic determi...

journal_title：Virus research

authors： Bailey D,Chard LS,Dash P,Barrett T,Banyard AC

更新日期：2007-06-01 00:00:00

abstract：:The positive sense genomes of members of the genus Flavivirus in the family Flaviviridae are ∼ 11 kb in length and have a 5' type I cap but no 3' poly-A. The 3' and 5' terminal regions contain short conserved sequences that are proposed to be repeated remnants of an ancient sequence. However, the functions of most of ...

journal_title：Virus research

authors： Brinton MA,Basu M

更新日期：2015-08-03 00:00:00

abstract：:Raccoons (Procyon lotor), which are not native to Japan, have been suspected to transmit various pathogens by frequent intrusion into agricultural and residential areas. To determine influenza A virus seropositivity in raccoons in Japan, we examined a total of 634 raccoons captured in 19 towns (A-S) from 2009 to 2012....

journal_title：Virus research

authors： Yamaguchi E,Sashika M,Fujii K,Kobayashi K,Bui VN,Ogawa H,Imai K

更新日期：2014-08-30 00:00:00

abstract：:To study the process of feline immunodeficiency virus (FIV) assembly, we examined the suitability of the vaccinia vector system to reproduce FIV particle formation. To this end, we constructed a recombinant vaccinia virus carrying the FIV gag gene. Biochemical and electron microscopy analyses of cells infected with th...

journal_title：Virus research

authors： Manrique ML,Celma CC,González SA,Affranchino JL

更新日期：2001-07-01 00:00:00

abstract：:Persistent infections with mumps virus were established in human B-lymphoid cell line Akata and in the human chronic myelogenous leukaemia cell line K562. Even after IFN treatment a drastic decrease in STAT-1alpha (signal transducers and activators of transcription-1alpha), STAT-2 and p48 (ISGF-3gamma: IFN-stimulated ...

journal_title：Virus research

authors： Fujii N,Yokosawa N,Shirakawa S

更新日期：1999-12-15 00:00:00

abstract：:Reports of human infections with highly pathogenic H5N1 avian influenza viruses in many countries in Asia and Africa with varying case fatality rates highlight the pandemic potential of these viruses. In order to contain a rapidly spreading influenza virus in a pandemic scenario, a vaccine which can induce rapid and r...

journal_title：Virus research

authors： Vemula SV,Amen O,Katz JM,Donis R,Sambhara S,Mittal SK

更新日期：2013-12-26 00:00:00