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Tolerance and immune response to the porcine endogenous retrovirus in German landrace pigs immunised with viral proteins.

Abstract：

:Immunisation of goats, mice, rats, rabbits, guinea pigs, and hamsters with the recombinant ectodomain of the porcine endogenous retrovirus (PERV) transmembrane envelope (TM) protein (p15E) induced binding and neutralising immune antibodies in all animals. In contrast, no antibodies were induced when pigs were immunised with p15E, indicating that pigs are tolerant to their endogenous retroviruses, at least to the TM protein. To answer the question of whether pigs are tolerant to other structural proteins of PERV, we immunised German landrace pigs with p15E, this time in conjunction with the surface envelope proteins gp70 and the core capsid Gag protein p27CA. To ensure that the pigs were immunocompetent and that immunisation was successful, all animals also received an injection of an unrelated protein, keyhole limpet hemocyanin (KLH). Whereas all animals produced antibodies against KLH, no animals produced antibodies against the viral envelope proteins, thus confirming previous results for p15E and extending them to the other envelope protein, gp70. However, the pigs did produce antibodies against p27CA, indicating that there is no tolerance to the core capsid protein of PERV.

journal_name

Virus Res

journal_title

Virus research

authors

Denner J,Petersen B,Niemann H

doi

10.1016/j.virusres.2015.05.019

subject

Has Abstract

pub_date

2015-10-02 00:00:00

pages

39-43

eissn

0168-1702

issn

1872-7492

pii

S0168-1702(15)00218-X

journal_volume

208

pub_type

杂志文章

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