Abstract：
:Viral expression varies widely between untransformed HTLV-1 positive clones derived from infected individuals without malignancy. Here we show that, in the absence of malignancy, 68% of HTLV-1 positive clones carry deleted (10%) or methylated (58%) 5' LTR. These changes were found to contribute to the fluctuation of viral expression between clones. 5' LTR deletions strongly impaired tax expression and thereby clonal expansion, telomere homeostasis, and genetic instability. The effects of CpG methylation on viral transcription were qualitatively and quantitatively different from those of LTR deletions and preserved the preleukemic features of HTLV-1(+)CD4(+) clones. 5' LTR methylation varied not only between clones but also between cells belonging to the same clones, between distinct integrated sequences within the same cells, and between CpG dyads along the 5' LTR. Such distributions suggest that a dynamic methylation spectrum might help sustain persistent infection.
journal_name
Virus Resjournal_title
Virus researchauthors
Sibon D,Zane L,Idrissi ME,Delfau-Larue MH,Gessain A,Gout O,Mortreux F,Wattel Edoi
10.1016/j.virusres.2013.08.010subject
Has Abstractpub_date
2013-12-26 00:00:00pages
452-61issue
2eissn
0168-1702issn
1872-7492pii
S0168-1702(13)00289-Xjournal_volume
178pub_type
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